Hyperleptinemia, Adiposity, and Risk of Metabolic Syndrome in Older Adults
Background. Abdominal adiposity and serum leptin increase with age as does risk of metabolic syndrome. This study investigates the prospective association between leptin and metabolic syndrome risk in relation to adiposity and cytokines. Methods. The Health, Aging, and Body Composition study is a pr...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Nutrition and Metabolism |
| Online Access: | http://dx.doi.org/10.1155/2013/327079 |
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| author | Suruchi Mishra Tamara B. Harris Trisha Hue Iva Miljkovic Suzanne Satterfield Nathalie de Rekeneire Mira Mehta Nadine R. Sahyoun |
| author_facet | Suruchi Mishra Tamara B. Harris Trisha Hue Iva Miljkovic Suzanne Satterfield Nathalie de Rekeneire Mira Mehta Nadine R. Sahyoun |
| author_sort | Suruchi Mishra |
| collection | DOAJ |
| description | Background. Abdominal adiposity and serum leptin increase with age as does risk of metabolic syndrome. This study investigates the prospective association between leptin and metabolic syndrome risk in relation to adiposity and cytokines. Methods. The Health, Aging, and Body Composition study is a prospective cohort of older adults aged 70 to 79 years. Baseline measurements included leptin, cytokines, BMI, total percent fat, and visceral and subcutaneous fat. Multivariate logistic regression was used to determine the association between leptin and metabolic syndrome (defined per NCEP ATP III) incidence after 6 years of follow-up among 1,120 men and women. Results. Leptin predicted metabolic syndrome in men (P for trend = 0.0002) and women (P for trend = 0.0001). In women, risk of metabolic syndrome increased with higher levels of leptin (compared with quintile 1, quintile 2 RR = 3.29, CI = 1.36, 7.95; quintile 3 RR = 3.25, CI = 1.33, 7.93; quintile 4 RR = 5.21, CI = 2.16, 12.56; and quintile 5 RR = 7.97, CI = 3.30, 19.24) after adjusting for potential confounders. Leptin remained independently associated with metabolic syndrome risk after additional adjustment for adiposity, cytokines, and CRP. Among men, this association was no longer significant after controlling for adiposity. Conclusion. Among older women, elevated concentrations of leptin may increase the risk of metabolic syndrome independent of adiposity and cytokines. |
| format | Article |
| id | doaj-art-6560dfc92a424c929d33157691b52b89 |
| institution | Kabale University |
| issn | 2090-0724 2090-0732 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nutrition and Metabolism |
| spelling | doaj-art-6560dfc92a424c929d33157691b52b892025-02-03T06:12:32ZengWileyJournal of Nutrition and Metabolism2090-07242090-07322013-01-01201310.1155/2013/327079327079Hyperleptinemia, Adiposity, and Risk of Metabolic Syndrome in Older AdultsSuruchi Mishra0Tamara B. Harris1Trisha Hue2Iva Miljkovic3Suzanne Satterfield4Nathalie de Rekeneire5Mira Mehta6Nadine R. Sahyoun7Department of Nutrition and Food Science, University of Maryland, College Park, MD 20742, USANational Institute on Aging, NIH, Bethesda, MD 20892, USAUniversity of California, San Francisco, CA 94107, USADepartment of Epidemiology, University of Pittsburg, Pittsburgh, PA 15213, USAMemphis Field Center, University of Tennessee, Memphis, TN 38163, USACenter on Disability and Disabling Disorders, New Haven, CT 06520, USADepartment of Nutrition and Food Science, University of Maryland, College Park, MD 20742, USADepartment of Nutrition and Food Science, University of Maryland, College Park, MD 20742, USABackground. Abdominal adiposity and serum leptin increase with age as does risk of metabolic syndrome. This study investigates the prospective association between leptin and metabolic syndrome risk in relation to adiposity and cytokines. Methods. The Health, Aging, and Body Composition study is a prospective cohort of older adults aged 70 to 79 years. Baseline measurements included leptin, cytokines, BMI, total percent fat, and visceral and subcutaneous fat. Multivariate logistic regression was used to determine the association between leptin and metabolic syndrome (defined per NCEP ATP III) incidence after 6 years of follow-up among 1,120 men and women. Results. Leptin predicted metabolic syndrome in men (P for trend = 0.0002) and women (P for trend = 0.0001). In women, risk of metabolic syndrome increased with higher levels of leptin (compared with quintile 1, quintile 2 RR = 3.29, CI = 1.36, 7.95; quintile 3 RR = 3.25, CI = 1.33, 7.93; quintile 4 RR = 5.21, CI = 2.16, 12.56; and quintile 5 RR = 7.97, CI = 3.30, 19.24) after adjusting for potential confounders. Leptin remained independently associated with metabolic syndrome risk after additional adjustment for adiposity, cytokines, and CRP. Among men, this association was no longer significant after controlling for adiposity. Conclusion. Among older women, elevated concentrations of leptin may increase the risk of metabolic syndrome independent of adiposity and cytokines.http://dx.doi.org/10.1155/2013/327079 |
| spellingShingle | Suruchi Mishra Tamara B. Harris Trisha Hue Iva Miljkovic Suzanne Satterfield Nathalie de Rekeneire Mira Mehta Nadine R. Sahyoun Hyperleptinemia, Adiposity, and Risk of Metabolic Syndrome in Older Adults Journal of Nutrition and Metabolism |
| title | Hyperleptinemia, Adiposity, and Risk of Metabolic Syndrome in Older Adults |
| title_full | Hyperleptinemia, Adiposity, and Risk of Metabolic Syndrome in Older Adults |
| title_fullStr | Hyperleptinemia, Adiposity, and Risk of Metabolic Syndrome in Older Adults |
| title_full_unstemmed | Hyperleptinemia, Adiposity, and Risk of Metabolic Syndrome in Older Adults |
| title_short | Hyperleptinemia, Adiposity, and Risk of Metabolic Syndrome in Older Adults |
| title_sort | hyperleptinemia adiposity and risk of metabolic syndrome in older adults |
| url | http://dx.doi.org/10.1155/2013/327079 |
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