Insights into the Effects of the Dental Stem Cell Secretome on Nerve Regeneration: Towards Cell-Free Treatment
Cell-free treatment is emerging as an alternative to cell delivery to promote endogenous regeneration using cell-derived factors. The purpose of this article was to systematically review studies of the effects of the dental stem cell secretome on nerve regeneration. PubMed and Scopus databases were...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2019/4596150 |
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| _version_ | 1832566820926652416 |
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| author | Rohaina Che Man Nadiah Sulaiman Ruszymah Bt Hj Idrus Shahrul Hisham Zainal Ariffin Rohaya Megat Abdul Wahab Muhammad Dain Yazid |
| author_facet | Rohaina Che Man Nadiah Sulaiman Ruszymah Bt Hj Idrus Shahrul Hisham Zainal Ariffin Rohaya Megat Abdul Wahab Muhammad Dain Yazid |
| author_sort | Rohaina Che Man |
| collection | DOAJ |
| description | Cell-free treatment is emerging as an alternative to cell delivery to promote endogenous regeneration using cell-derived factors. The purpose of this article was to systematically review studies of the effects of the dental stem cell secretome on nerve regeneration. PubMed and Scopus databases were used where searched and related studies were selected. The primary search identified 36 articles with the utilized keywords; however, only 13 articles met the defined inclusion criteria. Eight out of thirteen articles included in vivo and in vitro studies. We classified the dental stem cell-derived secretome with its nerve regeneration potential. All studies demonstrated that dental stem cell-derived factors promote neurotrophic effects that can mechanistically stimulate nerve regeneration in neurodegenerative diseases and nerve injury. This data collection will enable researchers to gather information to create a precise formulation for future prescribed treatments. |
| format | Article |
| id | doaj-art-6556b2ba60be45459d56f766513a70e1 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-6556b2ba60be45459d56f766513a70e12025-02-03T01:02:59ZengWileyStem Cells International1687-966X1687-96782019-01-01201910.1155/2019/45961504596150Insights into the Effects of the Dental Stem Cell Secretome on Nerve Regeneration: Towards Cell-Free TreatmentRohaina Che Man0Nadiah Sulaiman1Ruszymah Bt Hj Idrus2Shahrul Hisham Zainal Ariffin3Rohaya Megat Abdul Wahab4Muhammad Dain Yazid5Tissue Engineering Centre, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, 56000 Cheras, Kuala Lumpur, MalaysiaTissue Engineering Centre, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, 56000 Cheras, Kuala Lumpur, MalaysiaDepartment of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, 56000 Cheras, Kuala Lumpur, MalaysiaMalaysia Genome Institute (MGI), National Institute of Biotechnology Malaysia (NIBM), Jalan Bangi, 43000 Bangi, Selangor, MalaysiaDepartment of Orthodontic, Faculty of Dentistry, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, MalaysiaTissue Engineering Centre, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, 56000 Cheras, Kuala Lumpur, MalaysiaCell-free treatment is emerging as an alternative to cell delivery to promote endogenous regeneration using cell-derived factors. The purpose of this article was to systematically review studies of the effects of the dental stem cell secretome on nerve regeneration. PubMed and Scopus databases were used where searched and related studies were selected. The primary search identified 36 articles with the utilized keywords; however, only 13 articles met the defined inclusion criteria. Eight out of thirteen articles included in vivo and in vitro studies. We classified the dental stem cell-derived secretome with its nerve regeneration potential. All studies demonstrated that dental stem cell-derived factors promote neurotrophic effects that can mechanistically stimulate nerve regeneration in neurodegenerative diseases and nerve injury. This data collection will enable researchers to gather information to create a precise formulation for future prescribed treatments.http://dx.doi.org/10.1155/2019/4596150 |
| spellingShingle | Rohaina Che Man Nadiah Sulaiman Ruszymah Bt Hj Idrus Shahrul Hisham Zainal Ariffin Rohaya Megat Abdul Wahab Muhammad Dain Yazid Insights into the Effects of the Dental Stem Cell Secretome on Nerve Regeneration: Towards Cell-Free Treatment Stem Cells International |
| title | Insights into the Effects of the Dental Stem Cell Secretome on Nerve Regeneration: Towards Cell-Free Treatment |
| title_full | Insights into the Effects of the Dental Stem Cell Secretome on Nerve Regeneration: Towards Cell-Free Treatment |
| title_fullStr | Insights into the Effects of the Dental Stem Cell Secretome on Nerve Regeneration: Towards Cell-Free Treatment |
| title_full_unstemmed | Insights into the Effects of the Dental Stem Cell Secretome on Nerve Regeneration: Towards Cell-Free Treatment |
| title_short | Insights into the Effects of the Dental Stem Cell Secretome on Nerve Regeneration: Towards Cell-Free Treatment |
| title_sort | insights into the effects of the dental stem cell secretome on nerve regeneration towards cell free treatment |
| url | http://dx.doi.org/10.1155/2019/4596150 |
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