IL-1β and IL-6 Are Highly Expressed in RF+IgE+ Systemic Lupus Erythematous Subtype
Background. Systemic lupus erythematosus (SLE) is an autoimmune disease with great heterogeneity in pathogenesis and clinical symptoms. Rheumatoid factor (RF) is one key indicator for rheumatoid arthritis (RA) while immunoglobulin E (IgE) is associated with type I hypersensitivity. To better categor...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2017/5096741 |
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| author | Yongkang Wu Bei Cai Junlong Zhang Beilei Shen Zhuochun Huang Chunyu Tan Carla C. Baan Lanlan Wang |
| author_facet | Yongkang Wu Bei Cai Junlong Zhang Beilei Shen Zhuochun Huang Chunyu Tan Carla C. Baan Lanlan Wang |
| author_sort | Yongkang Wu |
| collection | DOAJ |
| description | Background. Systemic lupus erythematosus (SLE) is an autoimmune disease with great heterogeneity in pathogenesis and clinical symptoms. Rheumatoid factor (RF) is one key indicator for rheumatoid arthritis (RA) while immunoglobulin E (IgE) is associated with type I hypersensitivity. To better categorize SLE subtypes, we determined the dominant cytokines based on familial SLE patients. Methods. RF, IgE, and multiple cytokines (i.e., IL-1β, IL-6, IL-8, IL-10, IL-17, IFN-γ, IP-10, MCP-1, and MIP-1β) were measured in sera of familial SLE patients (n=3), noninherited SLE patients (n=108), and healthy controls (n=80). Results. Three familial SLE patients and 5 noninherited SLE cases are with features of RF+IgE+. These RF+IgE+ SLE patients expressed significantly higher levels of IL-1β and IL-6 than the other SLE patients (P<0.05). IL-6 correlated with both IgE and IL-1β levels in RF+IgE+ SLE patients (r2=0.583, P=0.027; r2=0.847, P=0.001), and IgE also correlated with IL-1β (r2=0.567, P=0.031). Conclusion. Both IL-1β and IL-6 are highly expressed cytokines in RF+IgE+ SLE subtype which may be related to the pathogenesis of this special SLE subtype and provide accurate treatment strategy by neutralizing IL-1β and IL-6. |
| format | Article |
| id | doaj-art-653d295260de46498e1e5b8651efbccc |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-653d295260de46498e1e5b8651efbccc2025-02-03T01:27:39ZengWileyJournal of Immunology Research2314-88612314-71562017-01-01201710.1155/2017/50967415096741IL-1β and IL-6 Are Highly Expressed in RF+IgE+ Systemic Lupus Erythematous SubtypeYongkang Wu0Bei Cai1Junlong Zhang2Beilei Shen3Zhuochun Huang4Chunyu Tan5Carla C. Baan6Lanlan Wang7Department of Laboratory Medicine, West China Hospital Affiliated to Sichuan University, Chengdu, ChinaDepartment of Laboratory Medicine, West China Hospital Affiliated to Sichuan University, Chengdu, ChinaDepartment of Laboratory Medicine, West China Hospital Affiliated to Sichuan University, Chengdu, ChinaDepartment of Laboratory Medicine, West China Hospital Affiliated to Sichuan University, Chengdu, ChinaDepartment of Laboratory Medicine, West China Hospital Affiliated to Sichuan University, Chengdu, ChinaDepartment of Rheumatology, West China Hospital Affiliated to Sichuan University, Chengdu, ChinaDepartment of Internal Medicine, Sector Nephrology & Transplantation, Erasmus MC, Rotterdam, NetherlandsDepartment of Laboratory Medicine, West China Hospital Affiliated to Sichuan University, Chengdu, ChinaBackground. Systemic lupus erythematosus (SLE) is an autoimmune disease with great heterogeneity in pathogenesis and clinical symptoms. Rheumatoid factor (RF) is one key indicator for rheumatoid arthritis (RA) while immunoglobulin E (IgE) is associated with type I hypersensitivity. To better categorize SLE subtypes, we determined the dominant cytokines based on familial SLE patients. Methods. RF, IgE, and multiple cytokines (i.e., IL-1β, IL-6, IL-8, IL-10, IL-17, IFN-γ, IP-10, MCP-1, and MIP-1β) were measured in sera of familial SLE patients (n=3), noninherited SLE patients (n=108), and healthy controls (n=80). Results. Three familial SLE patients and 5 noninherited SLE cases are with features of RF+IgE+. These RF+IgE+ SLE patients expressed significantly higher levels of IL-1β and IL-6 than the other SLE patients (P<0.05). IL-6 correlated with both IgE and IL-1β levels in RF+IgE+ SLE patients (r2=0.583, P=0.027; r2=0.847, P=0.001), and IgE also correlated with IL-1β (r2=0.567, P=0.031). Conclusion. Both IL-1β and IL-6 are highly expressed cytokines in RF+IgE+ SLE subtype which may be related to the pathogenesis of this special SLE subtype and provide accurate treatment strategy by neutralizing IL-1β and IL-6.http://dx.doi.org/10.1155/2017/5096741 |
| spellingShingle | Yongkang Wu Bei Cai Junlong Zhang Beilei Shen Zhuochun Huang Chunyu Tan Carla C. Baan Lanlan Wang IL-1β and IL-6 Are Highly Expressed in RF+IgE+ Systemic Lupus Erythematous Subtype Journal of Immunology Research |
| title | IL-1β and IL-6 Are Highly Expressed in RF+IgE+ Systemic Lupus Erythematous Subtype |
| title_full | IL-1β and IL-6 Are Highly Expressed in RF+IgE+ Systemic Lupus Erythematous Subtype |
| title_fullStr | IL-1β and IL-6 Are Highly Expressed in RF+IgE+ Systemic Lupus Erythematous Subtype |
| title_full_unstemmed | IL-1β and IL-6 Are Highly Expressed in RF+IgE+ Systemic Lupus Erythematous Subtype |
| title_short | IL-1β and IL-6 Are Highly Expressed in RF+IgE+ Systemic Lupus Erythematous Subtype |
| title_sort | il 1β and il 6 are highly expressed in rf ige systemic lupus erythematous subtype |
| url | http://dx.doi.org/10.1155/2017/5096741 |
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