Mechanisms and new advances in the efficacy of plant active ingredients in tendon-bone healing
Abstract The tendon-bone interface, known as the tenosynovial union or attachment, can be easily damaged by excessive exercise or trauma. Tendon-bone healing is a significant research topic in orthopedics, encompassing various aspects of sports injuries and postoperative recovery. Surgery is the mos...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-01-01
|
| Series: | Journal of Orthopaedic Surgery and Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13018-025-05483-y |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832571446414540800 |
|---|---|
| author | Yuan Li Wei Wang Wensheng Xu |
| author_facet | Yuan Li Wei Wang Wensheng Xu |
| author_sort | Yuan Li |
| collection | DOAJ |
| description | Abstract The tendon-bone interface, known as the tenosynovial union or attachment, can be easily damaged by excessive exercise or trauma. Tendon-bone healing is a significant research topic in orthopedics, encompassing various aspects of sports injuries and postoperative recovery. Surgery is the most common treatment; however, it has limited efficacy in promoting tendon-bone healing and carries a risk of postoperative recurrence, necessitating the search for more effective treatments. Recently, plant-active ingredients such as tanshinone IIA, astragaloside, ginsenoside Rb1, and resveratrol have garnered significant attention due to their unique advantages in promoting tendon-bone healing. This review outlines the various mechanisms and research progress of these four plant-active ingredients, as well as compound ingredients, in promoting tendon-bone healing. For instance, tanshinone IIA significantly accelerates the healing rate and improves healing quality through anti-inflammatory, antioxidant, and cell proliferation-promoting mechanisms. Astragaloside expedites tendon-bone healing and enhances the mechanical strength of healing tissues primarily through anti-inflammatory, antioxidant, and immunoregulatory effects. Ginsenoside Rb1 enhances local blood supply and facilitates tendon-bone tissue repair through angiogenesis, anti-inflammatory, and antioxidant pathways. Resveratrol protects cellular function and accelerates tissue healing due to its potent antioxidant and anti-inflammatory effects. Additionally, the mechanisms and progress of certain Chinese herbal compound components in tendon-bone healing are outlined. This review concludes that these four plant-active ingredients and herbal compound components promote tendon-bone healing through various mechanisms. The efficacy mechanisms and research progress of these plant-active ingredients are summarized to provide references for clinical treatment and related research. |
| format | Article |
| id | doaj-art-652fda2bf329439791ca6804483817af |
| institution | Kabale University |
| issn | 1749-799X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj-art-652fda2bf329439791ca6804483817af2025-02-02T12:34:12ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2025-01-0120111010.1186/s13018-025-05483-yMechanisms and new advances in the efficacy of plant active ingredients in tendon-bone healingYuan Li0Wei Wang1Wensheng Xu2The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and TechnologyThe First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and TechnologyThe First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and TechnologyAbstract The tendon-bone interface, known as the tenosynovial union or attachment, can be easily damaged by excessive exercise or trauma. Tendon-bone healing is a significant research topic in orthopedics, encompassing various aspects of sports injuries and postoperative recovery. Surgery is the most common treatment; however, it has limited efficacy in promoting tendon-bone healing and carries a risk of postoperative recurrence, necessitating the search for more effective treatments. Recently, plant-active ingredients such as tanshinone IIA, astragaloside, ginsenoside Rb1, and resveratrol have garnered significant attention due to their unique advantages in promoting tendon-bone healing. This review outlines the various mechanisms and research progress of these four plant-active ingredients, as well as compound ingredients, in promoting tendon-bone healing. For instance, tanshinone IIA significantly accelerates the healing rate and improves healing quality through anti-inflammatory, antioxidant, and cell proliferation-promoting mechanisms. Astragaloside expedites tendon-bone healing and enhances the mechanical strength of healing tissues primarily through anti-inflammatory, antioxidant, and immunoregulatory effects. Ginsenoside Rb1 enhances local blood supply and facilitates tendon-bone tissue repair through angiogenesis, anti-inflammatory, and antioxidant pathways. Resveratrol protects cellular function and accelerates tissue healing due to its potent antioxidant and anti-inflammatory effects. Additionally, the mechanisms and progress of certain Chinese herbal compound components in tendon-bone healing are outlined. This review concludes that these four plant-active ingredients and herbal compound components promote tendon-bone healing through various mechanisms. The efficacy mechanisms and research progress of these plant-active ingredients are summarized to provide references for clinical treatment and related research.https://doi.org/10.1186/s13018-025-05483-yTendon-bone healingPlant-active ingredientsMechanismsNew advancesEfficacy |
| spellingShingle | Yuan Li Wei Wang Wensheng Xu Mechanisms and new advances in the efficacy of plant active ingredients in tendon-bone healing Journal of Orthopaedic Surgery and Research Tendon-bone healing Plant-active ingredients Mechanisms New advances Efficacy |
| title | Mechanisms and new advances in the efficacy of plant active ingredients in tendon-bone healing |
| title_full | Mechanisms and new advances in the efficacy of plant active ingredients in tendon-bone healing |
| title_fullStr | Mechanisms and new advances in the efficacy of plant active ingredients in tendon-bone healing |
| title_full_unstemmed | Mechanisms and new advances in the efficacy of plant active ingredients in tendon-bone healing |
| title_short | Mechanisms and new advances in the efficacy of plant active ingredients in tendon-bone healing |
| title_sort | mechanisms and new advances in the efficacy of plant active ingredients in tendon bone healing |
| topic | Tendon-bone healing Plant-active ingredients Mechanisms New advances Efficacy |
| url | https://doi.org/10.1186/s13018-025-05483-y |
| work_keys_str_mv | AT yuanli mechanismsandnewadvancesintheefficacyofplantactiveingredientsintendonbonehealing AT weiwang mechanismsandnewadvancesintheefficacyofplantactiveingredientsintendonbonehealing AT wenshengxu mechanismsandnewadvancesintheefficacyofplantactiveingredientsintendonbonehealing |