Diarrhea as a Presenting Symptom of Disseminated Toxoplasmosis

Disseminated toxoplasmosis is uncommon in both immunocompetent and immunocompromised hosts with gastrointestinal involvement being rarely described. We report a case of disseminated gastrointestinal toxoplasmosis in an immunocompromised man who presented with one month of diarrhea and abdominal pain...

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Main Authors: Matthew Glover, Zhouwen Tang, Robert Sealock, Shilpa Jain
Format: Article
Language:English
Published: Wiley 2017-01-01
Series:Case Reports in Gastrointestinal Medicine
Online Access:http://dx.doi.org/10.1155/2017/3491087
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author Matthew Glover
Zhouwen Tang
Robert Sealock
Shilpa Jain
author_facet Matthew Glover
Zhouwen Tang
Robert Sealock
Shilpa Jain
author_sort Matthew Glover
collection DOAJ
description Disseminated toxoplasmosis is uncommon in both immunocompetent and immunocompromised hosts with gastrointestinal involvement being rarely described. We report a case of disseminated gastrointestinal toxoplasmosis in an immunocompromised man who presented with one month of diarrhea and abdominal pain. Imaging showed thickening of the ascending colon and cecum. Esophagogastroduodenoscopy and colonoscopy biopsies revealed Toxoplasma gondii, confirmed by immunostain. Symptoms completely resolved following treatment with pyrimethamine, sulfadiazine, and leucovorin. This case highlights the importance of including toxoplasmosis in the differential diagnosis of any immunocompromised individual presenting with gastrointestinal symptoms.
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institution Kabale University
issn 2090-6528
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publishDate 2017-01-01
publisher Wiley
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series Case Reports in Gastrointestinal Medicine
spelling doaj-art-6527c56efd03430c95affd53307a21442025-02-03T07:26:11ZengWileyCase Reports in Gastrointestinal Medicine2090-65282090-65362017-01-01201710.1155/2017/34910873491087Diarrhea as a Presenting Symptom of Disseminated ToxoplasmosisMatthew Glover0Zhouwen Tang1Robert Sealock2Shilpa Jain3Baylor College of Medicine, Houston, TX, USABaylor College of Medicine, Houston, TX, USABaylor College of Medicine, Houston, TX, USABaylor College of Medicine, Houston, TX, USADisseminated toxoplasmosis is uncommon in both immunocompetent and immunocompromised hosts with gastrointestinal involvement being rarely described. We report a case of disseminated gastrointestinal toxoplasmosis in an immunocompromised man who presented with one month of diarrhea and abdominal pain. Imaging showed thickening of the ascending colon and cecum. Esophagogastroduodenoscopy and colonoscopy biopsies revealed Toxoplasma gondii, confirmed by immunostain. Symptoms completely resolved following treatment with pyrimethamine, sulfadiazine, and leucovorin. This case highlights the importance of including toxoplasmosis in the differential diagnosis of any immunocompromised individual presenting with gastrointestinal symptoms.http://dx.doi.org/10.1155/2017/3491087
spellingShingle Matthew Glover
Zhouwen Tang
Robert Sealock
Shilpa Jain
Diarrhea as a Presenting Symptom of Disseminated Toxoplasmosis
Case Reports in Gastrointestinal Medicine
title Diarrhea as a Presenting Symptom of Disseminated Toxoplasmosis
title_full Diarrhea as a Presenting Symptom of Disseminated Toxoplasmosis
title_fullStr Diarrhea as a Presenting Symptom of Disseminated Toxoplasmosis
title_full_unstemmed Diarrhea as a Presenting Symptom of Disseminated Toxoplasmosis
title_short Diarrhea as a Presenting Symptom of Disseminated Toxoplasmosis
title_sort diarrhea as a presenting symptom of disseminated toxoplasmosis
url http://dx.doi.org/10.1155/2017/3491087
work_keys_str_mv AT matthewglover diarrheaasapresentingsymptomofdisseminatedtoxoplasmosis
AT zhouwentang diarrheaasapresentingsymptomofdisseminatedtoxoplasmosis
AT robertsealock diarrheaasapresentingsymptomofdisseminatedtoxoplasmosis
AT shilpajain diarrheaasapresentingsymptomofdisseminatedtoxoplasmosis