Evaluation of Clinical Variables Associated with Increased Carotid Intima-Media Thickness in Middle-Aged Hypertensive Women
It has been previously documented that carotid intima-media thickness (cIMT) is a predictor of cardiovascular disease. The aim of this study was to identify clinical parameters associated with an increased cIMT treated hypertensive women. Female patients (n=116) with essential hypertension, aged 40–...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.1155/2012/257501 |
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| author | Michelle Trindade Renata Brum Martucci Adriana K. Burlá Wille Oigman Mario Fritsch Neves Denizar Vianna Araújo |
| author_facet | Michelle Trindade Renata Brum Martucci Adriana K. Burlá Wille Oigman Mario Fritsch Neves Denizar Vianna Araújo |
| author_sort | Michelle Trindade |
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| description | It has been previously documented that carotid intima-media thickness (cIMT) is a predictor of cardiovascular disease. The aim of this study was to identify clinical parameters associated with an increased cIMT treated hypertensive women. Female patients (n=116) with essential hypertension, aged 40–65 years, were included in this study. Vascular ultrasound was performed and the patients were divided into two groups according to the values of cIMT (< or ≥0.9 mm). Patients with greater cIMT presented significantly higher systolic blood pressure and pulse pressure. Serum HDL-cholesterol was significantly lower and CRP was significantly higher in the same group. There was a significant correlation between cIMT and age (r=0.25, P=0.007), systolic blood pressure (r=0.19, P=0.009), pulse pressure (r=0.30, P=0.001), and LDL-cholesterol (r=0.19, P=0.043). cIMT was correlated to CRP (r=0.31, P=0.007) and negatively correlated to HDL-cholesterol (r=0.33, P=0.001). In logistic regression, only HDL-cholesterol, CRP, and pulse pressure were shown to be independent variables associated to increased cIMT. In conclusion, pulse pressure, HDL-cholesterol, and CRP are variables correlated with cIMT in treated hypertensive women. |
| format | Article |
| id | doaj-art-6522f03bb96e4f2aa286966b333f3df3 |
| institution | Kabale University |
| issn | 2090-0384 2090-0392 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-6522f03bb96e4f2aa286966b333f3df32025-02-03T01:21:45ZengWileyInternational Journal of Hypertension2090-03842090-03922012-01-01201210.1155/2012/257501257501Evaluation of Clinical Variables Associated with Increased Carotid Intima-Media Thickness in Middle-Aged Hypertensive WomenMichelle Trindade0Renata Brum Martucci1Adriana K. Burlá2Wille Oigman3Mario Fritsch Neves4Denizar Vianna Araújo5Department of Clinical Medicine, State University of Rio de Janeiro, Rua Vinte e Oito de Setembro, 77, Sala 329—Vila Isabel, 20551-030—Rio de Janeiro, RJ, BrazilInstitution of Nutrition, State University of Rio de Janeiro, Rua Vinte e Oito de Setembro, 77, Sala 329, Vila Isabel, 20551-030 Rio de Janeiro, RJ, BrazilDepartment of Clinical Medicine, State University of Rio de Janeiro, Rua Vinte e Oito de Setembro, 77, Sala 329—Vila Isabel, 20551-030—Rio de Janeiro, RJ, BrazilDepartment of Clinical Medicine, State University of Rio de Janeiro, Rua Vinte e Oito de Setembro, 77, Sala 329—Vila Isabel, 20551-030—Rio de Janeiro, RJ, BrazilDepartment of Clinical Medicine, State University of Rio de Janeiro, Rua Vinte e Oito de Setembro, 77, Sala 329—Vila Isabel, 20551-030—Rio de Janeiro, RJ, BrazilDepartment of Clinical Medicine, State University of Rio de Janeiro, Rua Vinte e Oito de Setembro, 77, Sala 329—Vila Isabel, 20551-030—Rio de Janeiro, RJ, BrazilIt has been previously documented that carotid intima-media thickness (cIMT) is a predictor of cardiovascular disease. The aim of this study was to identify clinical parameters associated with an increased cIMT treated hypertensive women. Female patients (n=116) with essential hypertension, aged 40–65 years, were included in this study. Vascular ultrasound was performed and the patients were divided into two groups according to the values of cIMT (< or ≥0.9 mm). Patients with greater cIMT presented significantly higher systolic blood pressure and pulse pressure. Serum HDL-cholesterol was significantly lower and CRP was significantly higher in the same group. There was a significant correlation between cIMT and age (r=0.25, P=0.007), systolic blood pressure (r=0.19, P=0.009), pulse pressure (r=0.30, P=0.001), and LDL-cholesterol (r=0.19, P=0.043). cIMT was correlated to CRP (r=0.31, P=0.007) and negatively correlated to HDL-cholesterol (r=0.33, P=0.001). In logistic regression, only HDL-cholesterol, CRP, and pulse pressure were shown to be independent variables associated to increased cIMT. In conclusion, pulse pressure, HDL-cholesterol, and CRP are variables correlated with cIMT in treated hypertensive women.http://dx.doi.org/10.1155/2012/257501 |
| spellingShingle | Michelle Trindade Renata Brum Martucci Adriana K. Burlá Wille Oigman Mario Fritsch Neves Denizar Vianna Araújo Evaluation of Clinical Variables Associated with Increased Carotid Intima-Media Thickness in Middle-Aged Hypertensive Women International Journal of Hypertension |
| title | Evaluation of Clinical Variables Associated with Increased Carotid Intima-Media Thickness in Middle-Aged Hypertensive Women |
| title_full | Evaluation of Clinical Variables Associated with Increased Carotid Intima-Media Thickness in Middle-Aged Hypertensive Women |
| title_fullStr | Evaluation of Clinical Variables Associated with Increased Carotid Intima-Media Thickness in Middle-Aged Hypertensive Women |
| title_full_unstemmed | Evaluation of Clinical Variables Associated with Increased Carotid Intima-Media Thickness in Middle-Aged Hypertensive Women |
| title_short | Evaluation of Clinical Variables Associated with Increased Carotid Intima-Media Thickness in Middle-Aged Hypertensive Women |
| title_sort | evaluation of clinical variables associated with increased carotid intima media thickness in middle aged hypertensive women |
| url | http://dx.doi.org/10.1155/2012/257501 |
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