Oral and intestinal manifestations of giant cell arteritis
Background: Giant cell arteritis (GCA) is the most common primary vasculitis in individuals over 50 years of age. GCA typically affects large- and medium-sized arteries and is classically associated with cranial manifestations of ischaemia, such as headaches (notably in the temporal region), jaw cla...
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SMC MEDIA SRL
2025-01-01
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| Series: | European Journal of Case Reports in Internal Medicine |
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| Online Access: | https://www.ejcrim.com/index.php/EJCRIM/article/view/5081 |
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| author | Mathieu Pernet Laura Moi Fulvia Serra Nicolas Garin |
| author_facet | Mathieu Pernet Laura Moi Fulvia Serra Nicolas Garin |
| author_sort | Mathieu Pernet |
| collection | DOAJ |
| description | Background: Giant cell arteritis (GCA) is the most common primary vasculitis in individuals over 50 years of age. GCA typically affects large- and medium-sized arteries and is classically associated with cranial manifestations of ischaemia, such as headaches (notably in the temporal region), jaw claudication and visual symptoms that can lead to blindness. Extracranial symptoms are less frequently reported and are related to involvement of the thoracic and abdominal aorta and its main branches. Classic diagnostic tools (such as temporal artery ultrasonography and temporal artery biopsy) can be negative in extracranial GCA.
Case description: We report a difficult diagnosis of GCA in a 75-year-old woman who developed painful tongue ulcers that responded to prednisone treatment. However, a comprehensive diagnostic work-up did not lead to a certain diagnosis of GCA and corticosteroids were stopped after one month. A few months later, the patient suffered from mechanical ileus secondary to ischaemic stenosis of the small bowel. Pathological examination of the small bowel resection, and a second FDG-PET/CT, led to the diagnosis of extracranial GCA.
Conclusions: We present a case of CGA which sequentially affected cranial and extracranial arteries and illustrate pitfalls in the diagnosis of this polymorph condition. |
| format | Article |
| id | doaj-art-6521eee12e134d9a990ebd0d99c90fab |
| institution | Kabale University |
| issn | 2284-2594 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SMC MEDIA SRL |
| record_format | Article |
| series | European Journal of Case Reports in Internal Medicine |
| spelling | doaj-art-6521eee12e134d9a990ebd0d99c90fab2025-02-04T13:37:20ZengSMC MEDIA SRLEuropean Journal of Case Reports in Internal Medicine2284-25942025-01-0110.12890/2025_0050814616Oral and intestinal manifestations of giant cell arteritisMathieu Pernet0Laura Moi1Fulvia Serra2Nicolas Garin3Department of Internal Medicine, Riviera-Chablais Hospital, Rennaz, SwitzerlandDivision of Allergy and Immunology, Central hospitals Institute, Sion, SwitzerlandDivision of Histocytopathology, Central hospitals Institute, Sion, SwitzerlandDepartment of Internal Medicine, Riviera-Chablais Hospital, Rennaz, Switzerland; University of Geneva, Geneva, SwitzerlandBackground: Giant cell arteritis (GCA) is the most common primary vasculitis in individuals over 50 years of age. GCA typically affects large- and medium-sized arteries and is classically associated with cranial manifestations of ischaemia, such as headaches (notably in the temporal region), jaw claudication and visual symptoms that can lead to blindness. Extracranial symptoms are less frequently reported and are related to involvement of the thoracic and abdominal aorta and its main branches. Classic diagnostic tools (such as temporal artery ultrasonography and temporal artery biopsy) can be negative in extracranial GCA. Case description: We report a difficult diagnosis of GCA in a 75-year-old woman who developed painful tongue ulcers that responded to prednisone treatment. However, a comprehensive diagnostic work-up did not lead to a certain diagnosis of GCA and corticosteroids were stopped after one month. A few months later, the patient suffered from mechanical ileus secondary to ischaemic stenosis of the small bowel. Pathological examination of the small bowel resection, and a second FDG-PET/CT, led to the diagnosis of extracranial GCA. Conclusions: We present a case of CGA which sequentially affected cranial and extracranial arteries and illustrate pitfalls in the diagnosis of this polymorph condition.https://www.ejcrim.com/index.php/EJCRIM/article/view/5081giant cell arteritislingual ulcerationsmesenteric ischaemia |
| spellingShingle | Mathieu Pernet Laura Moi Fulvia Serra Nicolas Garin Oral and intestinal manifestations of giant cell arteritis European Journal of Case Reports in Internal Medicine giant cell arteritis lingual ulcerations mesenteric ischaemia |
| title | Oral and intestinal manifestations of giant cell arteritis |
| title_full | Oral and intestinal manifestations of giant cell arteritis |
| title_fullStr | Oral and intestinal manifestations of giant cell arteritis |
| title_full_unstemmed | Oral and intestinal manifestations of giant cell arteritis |
| title_short | Oral and intestinal manifestations of giant cell arteritis |
| title_sort | oral and intestinal manifestations of giant cell arteritis |
| topic | giant cell arteritis lingual ulcerations mesenteric ischaemia |
| url | https://www.ejcrim.com/index.php/EJCRIM/article/view/5081 |
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