Causal relationships between gut microbiota and polycystic ovarian syndrome: A bidirectional Mendelian randomization study
Abstract Introduction Previous studies have established a link between gut microbiota and polycystic ovary syndrome (PCOS), but little is known about their precise causal relationship. Therefore, this study aims to explore whether there are precise causal relationships between gut microbiota and PCO...
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Wiley
2024-11-01
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| Series: | Acta Obstetricia et Gynecologica Scandinavica |
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| Online Access: | https://doi.org/10.1111/aogs.14957 |
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| author | Ruo‐Lin Mao Xiang‐Fei Wang Jue‐Pu Zhou Meng Wang Rui Long Lei Jin Li‐Xia Zhu |
| author_facet | Ruo‐Lin Mao Xiang‐Fei Wang Jue‐Pu Zhou Meng Wang Rui Long Lei Jin Li‐Xia Zhu |
| author_sort | Ruo‐Lin Mao |
| collection | DOAJ |
| description | Abstract Introduction Previous studies have established a link between gut microbiota and polycystic ovary syndrome (PCOS), but little is known about their precise causal relationship. Therefore, this study aims to explore whether there are precise causal relationships between gut microbiota and PCOS. Material and Methods We performed a bidirectional two‐sample Mendelian randomization (MR) analysis. Datasets were from the largest published meta‐analysis on gut microbiota composition and the FinnGen cohort of the IEU Open Genome‐Wide Association Study Project database. Inverse variance weighted (IVW), MR‐Egger, constrained maximum likelihood‐based Mendelian randomization, weighted median, weighted mode, and simple mode were used. Cochran's Q and MR‐Egger intercept tests were employed to measure the heterogeneity. Results A total of 211 gut microbiota taxa were identified in MR analysis. Nine taxa of bacteria, including Alphaproteobacteria (0.55, 0.30–0.99, p = 0.04), Bacilli (1.76, 1.07–2.91, p = 0.03), Bilophila (0.42, 0.23–0.77, p < 0.01), Blautia (0.16, 0.03–0.79, p = 0.02), Burkholderiales (2.37, 1.22–4.62, p = 0.01), Candidatus Soleaferrea (0.65, 0.43–0.98, p = 0.04), Cyanobacteria (0.51, 0.31–0.83, p = 0.01), Holdemania (0.53, 0.35–0.81, p < 0.01), and Lachnospiraceae (1.86, 1.04–3.35, p = 0.03), were found to be associated with PCOS in the above MR methods included at least IVW method. Cochran's Q statistics and MR‐Egger intercept test suggested no significant heterogeneity. In addition, 69 taxa were shown significant for at least the IVW method in reverse MR analysis, of these, 25 had a positive correlation, and 37 had a negative correlation. Additionally, Alphaproteobacteria and Lachnospiraceae (0.95, 0.91–0.98, p < 0.01; 0.97, 0.94–0.99, p = 0.02, respectively) were shown a bidirected causally association with PCOS. Conclusions Our study provides evidence of the bidirectional causal association between gut microbiota and PCOS from a genetic perspective. |
| format | Article |
| id | doaj-art-651c9b3e245b4077a1835b7cdf1d3077 |
| institution | OA Journals |
| issn | 0001-6349 1600-0412 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wiley |
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| series | Acta Obstetricia et Gynecologica Scandinavica |
| spelling | doaj-art-651c9b3e245b4077a1835b7cdf1d30772025-08-20T02:09:27ZengWileyActa Obstetricia et Gynecologica Scandinavica0001-63491600-04122024-11-01103112232224110.1111/aogs.14957Causal relationships between gut microbiota and polycystic ovarian syndrome: A bidirectional Mendelian randomization studyRuo‐Lin Mao0Xiang‐Fei Wang1Jue‐Pu Zhou2Meng Wang3Rui Long4Lei Jin5Li‐Xia Zhu6Reproductive Medicine Center, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan ChinaReproductive Medicine Center, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan ChinaReproductive Medicine Center, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan ChinaReproductive Medicine Center, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan ChinaReproductive Medicine Center, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan ChinaReproductive Medicine Center, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan ChinaReproductive Medicine Center, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan ChinaAbstract Introduction Previous studies have established a link between gut microbiota and polycystic ovary syndrome (PCOS), but little is known about their precise causal relationship. Therefore, this study aims to explore whether there are precise causal relationships between gut microbiota and PCOS. Material and Methods We performed a bidirectional two‐sample Mendelian randomization (MR) analysis. Datasets were from the largest published meta‐analysis on gut microbiota composition and the FinnGen cohort of the IEU Open Genome‐Wide Association Study Project database. Inverse variance weighted (IVW), MR‐Egger, constrained maximum likelihood‐based Mendelian randomization, weighted median, weighted mode, and simple mode were used. Cochran's Q and MR‐Egger intercept tests were employed to measure the heterogeneity. Results A total of 211 gut microbiota taxa were identified in MR analysis. Nine taxa of bacteria, including Alphaproteobacteria (0.55, 0.30–0.99, p = 0.04), Bacilli (1.76, 1.07–2.91, p = 0.03), Bilophila (0.42, 0.23–0.77, p < 0.01), Blautia (0.16, 0.03–0.79, p = 0.02), Burkholderiales (2.37, 1.22–4.62, p = 0.01), Candidatus Soleaferrea (0.65, 0.43–0.98, p = 0.04), Cyanobacteria (0.51, 0.31–0.83, p = 0.01), Holdemania (0.53, 0.35–0.81, p < 0.01), and Lachnospiraceae (1.86, 1.04–3.35, p = 0.03), were found to be associated with PCOS in the above MR methods included at least IVW method. Cochran's Q statistics and MR‐Egger intercept test suggested no significant heterogeneity. In addition, 69 taxa were shown significant for at least the IVW method in reverse MR analysis, of these, 25 had a positive correlation, and 37 had a negative correlation. Additionally, Alphaproteobacteria and Lachnospiraceae (0.95, 0.91–0.98, p < 0.01; 0.97, 0.94–0.99, p = 0.02, respectively) were shown a bidirected causally association with PCOS. Conclusions Our study provides evidence of the bidirectional causal association between gut microbiota and PCOS from a genetic perspective.https://doi.org/10.1111/aogs.14957causal inferencegut microbiotaGWASMendelian randomizationpolycystic ovary syndrome |
| spellingShingle | Ruo‐Lin Mao Xiang‐Fei Wang Jue‐Pu Zhou Meng Wang Rui Long Lei Jin Li‐Xia Zhu Causal relationships between gut microbiota and polycystic ovarian syndrome: A bidirectional Mendelian randomization study Acta Obstetricia et Gynecologica Scandinavica causal inference gut microbiota GWAS Mendelian randomization polycystic ovary syndrome |
| title | Causal relationships between gut microbiota and polycystic ovarian syndrome: A bidirectional Mendelian randomization study |
| title_full | Causal relationships between gut microbiota and polycystic ovarian syndrome: A bidirectional Mendelian randomization study |
| title_fullStr | Causal relationships between gut microbiota and polycystic ovarian syndrome: A bidirectional Mendelian randomization study |
| title_full_unstemmed | Causal relationships between gut microbiota and polycystic ovarian syndrome: A bidirectional Mendelian randomization study |
| title_short | Causal relationships between gut microbiota and polycystic ovarian syndrome: A bidirectional Mendelian randomization study |
| title_sort | causal relationships between gut microbiota and polycystic ovarian syndrome a bidirectional mendelian randomization study |
| topic | causal inference gut microbiota GWAS Mendelian randomization polycystic ovary syndrome |
| url | https://doi.org/10.1111/aogs.14957 |
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