Role of Coagulation Factors in Hepatocellular Carcinoma: A Literature Review
Hepatocyte carcinoma (HCC) is a globally prevalent neoplasm with profound effects on morbidity and mortality rates. This review summarizes the complex interactions between coagulation abnormalities and the pathophysiological mechanisms underlying HCC. Essential coagulation biomarkers, such as P-sele...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-12-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/15/1/34 |
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| author | Azeem Azam Aleksandra Klisic Filiz Mercantepe Hamza Faseeh Tolga Mercantepe Saira Rafaqat |
| author_facet | Azeem Azam Aleksandra Klisic Filiz Mercantepe Hamza Faseeh Tolga Mercantepe Saira Rafaqat |
| author_sort | Azeem Azam |
| collection | DOAJ |
| description | Hepatocyte carcinoma (HCC) is a globally prevalent neoplasm with profound effects on morbidity and mortality rates. This review summarizes the complex interactions between coagulation abnormalities and the pathophysiological mechanisms underlying HCC. Essential coagulation biomarkers, such as P-selectin, thrombomodulin, <span style="font-variant: small-caps;">d</span>-dimer, prothrombin, and von Willebrand factor, are reviewed for their diagnostic, prognostic, and therapeutic significance. The contribution of these biomarkers to tumor progression, metastatic spread, and patient prognosis is highlighted through a synthesis of contemporary research findings. In addition, this review highlights the underlying mechanisms linking coagulation pathways to HCC pathogenesis and explores potential therapeutic targets. An integrative perspective on the role of coagulation markers in HCC may improve clinical management strategies for patients affected by this malignancy. |
| format | Article |
| id | doaj-art-651976c6155240878db7784c51af26aa |
| institution | Kabale University |
| issn | 2075-1729 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj-art-651976c6155240878db7784c51af26aa2025-01-24T13:38:31ZengMDPI AGLife2075-17292024-12-011513410.3390/life15010034Role of Coagulation Factors in Hepatocellular Carcinoma: A Literature ReviewAzeem Azam0Aleksandra Klisic1Filiz Mercantepe2Hamza Faseeh3Tolga Mercantepe4Saira Rafaqat5Institute of Zoology, University of the Punjab, Lahore 54590, PakistanFaculty of Medicine, University of Montenegro, 81000 Podgorica, MontenegroDepartment of Endocrinology and Metabolism, Faculty of Medicine, Recep Tayyip Erdogan University, Rize 53200, TürkiyeDepartment of Zoology, Govt. Islamia Graduate College Civil Lines, Lahore 54000, PakistanDepartment of Histology, Faculty of Medicine, Recep Tayyip Erdogan University, Rize 53200, TürkiyeDepartment of Zoology, Lahore College for Women University, Lahore 44444, PakistanHepatocyte carcinoma (HCC) is a globally prevalent neoplasm with profound effects on morbidity and mortality rates. This review summarizes the complex interactions between coagulation abnormalities and the pathophysiological mechanisms underlying HCC. Essential coagulation biomarkers, such as P-selectin, thrombomodulin, <span style="font-variant: small-caps;">d</span>-dimer, prothrombin, and von Willebrand factor, are reviewed for their diagnostic, prognostic, and therapeutic significance. The contribution of these biomarkers to tumor progression, metastatic spread, and patient prognosis is highlighted through a synthesis of contemporary research findings. In addition, this review highlights the underlying mechanisms linking coagulation pathways to HCC pathogenesis and explores potential therapeutic targets. An integrative perspective on the role of coagulation markers in HCC may improve clinical management strategies for patients affected by this malignancy.https://www.mdpi.com/2075-1729/15/1/34hepatocellular carcinomacoagulation factorspathophysiology |
| spellingShingle | Azeem Azam Aleksandra Klisic Filiz Mercantepe Hamza Faseeh Tolga Mercantepe Saira Rafaqat Role of Coagulation Factors in Hepatocellular Carcinoma: A Literature Review Life hepatocellular carcinoma coagulation factors pathophysiology |
| title | Role of Coagulation Factors in Hepatocellular Carcinoma: A Literature Review |
| title_full | Role of Coagulation Factors in Hepatocellular Carcinoma: A Literature Review |
| title_fullStr | Role of Coagulation Factors in Hepatocellular Carcinoma: A Literature Review |
| title_full_unstemmed | Role of Coagulation Factors in Hepatocellular Carcinoma: A Literature Review |
| title_short | Role of Coagulation Factors in Hepatocellular Carcinoma: A Literature Review |
| title_sort | role of coagulation factors in hepatocellular carcinoma a literature review |
| topic | hepatocellular carcinoma coagulation factors pathophysiology |
| url | https://www.mdpi.com/2075-1729/15/1/34 |
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