The Effect of Thyroid Dysfunction on the Cardiovascular Risk of Type 2 Diabetes Mellitus Patients in Ghana
Background. Thyroid dysfunction is known to exaggerate the coronary heart disease (CHD) risk associated with type 2 diabetes mellitus (T2DM) among whites. The effect is yet to be studied among African populations. Methods. This is a cross-sectional study involving 780 T2DM patients enrolled in a dia...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2018/4783093 |
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| author | Osei Sarfo-Kantanka Fred Stephen Sarfo Eunice Oparebea Ansah Ishmael Kyei |
| author_facet | Osei Sarfo-Kantanka Fred Stephen Sarfo Eunice Oparebea Ansah Ishmael Kyei |
| author_sort | Osei Sarfo-Kantanka |
| collection | DOAJ |
| description | Background. Thyroid dysfunction is known to exaggerate the coronary heart disease (CHD) risk associated with type 2 diabetes mellitus (T2DM) among whites. The effect is yet to be studied among African populations. Methods. This is a cross-sectional study involving 780 T2DM patients enrolled in a diabetes clinic in Kumasi, Ghana. CHD risk was estimated using the Framingham and UKPDS risk scores. Risks were categorised as low (<10%), intermediate (10–19%), and high (≥20%). Associations between metabolic risk factors, thyroid dysfunction, and CHD risk were measured using Spearman’s partial correlation analysis while controlling for age and gender. Differences were considered statistically significant at p<0.05. Results. 780 T2DM patients (57.7% females), mean ± SD age of 57.4 ± 9.4 was analysed. The median (IQR) 10-year CHD score estimated using the Framingham and UKPDS risk engines for males and females was 12 (8–20), 9.4 (5.7–13.4), p<0.0001 and 3 (1–6), 5.8 (3.4–9.6), p<0.0001, respectively. Positive correlation was found between CHD risk and HbA1c, total cholesterol, low-density lipoprotein cholesterol, systolic blood pressure, and thyroid stimulating hormone. Conclusion. The presence of thyroid dysfunction significantly increased the CHD risk associated with T2DM patients in Ghana. |
| format | Article |
| id | doaj-art-650e8e99b7314546ace1d1e300f84c0e |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-650e8e99b7314546ace1d1e300f84c0e2025-02-03T01:10:55ZengWileyJournal of Diabetes Research2314-67452314-67532018-01-01201810.1155/2018/47830934783093The Effect of Thyroid Dysfunction on the Cardiovascular Risk of Type 2 Diabetes Mellitus Patients in GhanaOsei Sarfo-Kantanka0Fred Stephen Sarfo1Eunice Oparebea Ansah2Ishmael Kyei3Komfo Anokye Teaching Hospital, Kumasi, GhanaKomfo Anokye Teaching Hospital, Kumasi, GhanaKomfo Anokye Teaching Hospital, Kumasi, GhanaKomfo Anokye Teaching Hospital, Kumasi, GhanaBackground. Thyroid dysfunction is known to exaggerate the coronary heart disease (CHD) risk associated with type 2 diabetes mellitus (T2DM) among whites. The effect is yet to be studied among African populations. Methods. This is a cross-sectional study involving 780 T2DM patients enrolled in a diabetes clinic in Kumasi, Ghana. CHD risk was estimated using the Framingham and UKPDS risk scores. Risks were categorised as low (<10%), intermediate (10–19%), and high (≥20%). Associations between metabolic risk factors, thyroid dysfunction, and CHD risk were measured using Spearman’s partial correlation analysis while controlling for age and gender. Differences were considered statistically significant at p<0.05. Results. 780 T2DM patients (57.7% females), mean ± SD age of 57.4 ± 9.4 was analysed. The median (IQR) 10-year CHD score estimated using the Framingham and UKPDS risk engines for males and females was 12 (8–20), 9.4 (5.7–13.4), p<0.0001 and 3 (1–6), 5.8 (3.4–9.6), p<0.0001, respectively. Positive correlation was found between CHD risk and HbA1c, total cholesterol, low-density lipoprotein cholesterol, systolic blood pressure, and thyroid stimulating hormone. Conclusion. The presence of thyroid dysfunction significantly increased the CHD risk associated with T2DM patients in Ghana.http://dx.doi.org/10.1155/2018/4783093 |
| spellingShingle | Osei Sarfo-Kantanka Fred Stephen Sarfo Eunice Oparebea Ansah Ishmael Kyei The Effect of Thyroid Dysfunction on the Cardiovascular Risk of Type 2 Diabetes Mellitus Patients in Ghana Journal of Diabetes Research |
| title | The Effect of Thyroid Dysfunction on the Cardiovascular Risk of Type 2 Diabetes Mellitus Patients in Ghana |
| title_full | The Effect of Thyroid Dysfunction on the Cardiovascular Risk of Type 2 Diabetes Mellitus Patients in Ghana |
| title_fullStr | The Effect of Thyroid Dysfunction on the Cardiovascular Risk of Type 2 Diabetes Mellitus Patients in Ghana |
| title_full_unstemmed | The Effect of Thyroid Dysfunction on the Cardiovascular Risk of Type 2 Diabetes Mellitus Patients in Ghana |
| title_short | The Effect of Thyroid Dysfunction on the Cardiovascular Risk of Type 2 Diabetes Mellitus Patients in Ghana |
| title_sort | effect of thyroid dysfunction on the cardiovascular risk of type 2 diabetes mellitus patients in ghana |
| url | http://dx.doi.org/10.1155/2018/4783093 |
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