Diffusion-driven self-assembly of emerin nanodomains at the nuclear envelope
Emerin, a nuclear membrane protein with important biological roles in mechanotransduction and nuclear shape adaptation, self-assembles into nanometer-size domains at the inner nuclear membrane. The size and emerin occupancy of these nanodomains change with applied mechanical stress as well as under...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
American Physical Society
2025-01-01
|
| Series: | Physical Review Research |
| Online Access: | http://doi.org/10.1103/PhysRevResearch.7.L012019 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832590471639072768 |
|---|---|
| author | Carlos D. Alas Liying Wu Fabien Pinaud Christoph A. Haselwandter |
| author_facet | Carlos D. Alas Liying Wu Fabien Pinaud Christoph A. Haselwandter |
| author_sort | Carlos D. Alas |
| collection | DOAJ |
| description | Emerin, a nuclear membrane protein with important biological roles in mechanotransduction and nuclear shape adaptation, self-assembles into nanometer-size domains at the inner nuclear membrane. The size and emerin occupancy of these nanodomains change with applied mechanical stress as well as under emerin mutations associated with Emery-Dreifuss muscular dystrophy (EDMD). Through a combination of theory and experiment, we show here that a simple reaction-diffusion model explains the self-assembly of emerin nanodomains. Our model yields quantitative agreement with experimental observations on the size and occupancy of emerin nanodomains for wild-type emerin and EDMD-associated mutations of emerin, with and without applied forces, and allows successful prediction of emerin diffusion coefficients from observations of the overall properties of emerin nanodomains. Our results provide a physical understanding of EDMD-associated defects in emerin organization in terms of changes in key reaction and diffusion properties of emerin and its nuclear binding partners. |
| format | Article |
| id | doaj-art-6504663883da4deeb5d8247fdc32583c |
| institution | Kabale University |
| issn | 2643-1564 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | American Physical Society |
| record_format | Article |
| series | Physical Review Research |
| spelling | doaj-art-6504663883da4deeb5d8247fdc32583c2025-01-23T15:01:19ZengAmerican Physical SocietyPhysical Review Research2643-15642025-01-0171L01201910.1103/PhysRevResearch.7.L012019Diffusion-driven self-assembly of emerin nanodomains at the nuclear envelopeCarlos D. AlasLiying WuFabien PinaudChristoph A. HaselwandterEmerin, a nuclear membrane protein with important biological roles in mechanotransduction and nuclear shape adaptation, self-assembles into nanometer-size domains at the inner nuclear membrane. The size and emerin occupancy of these nanodomains change with applied mechanical stress as well as under emerin mutations associated with Emery-Dreifuss muscular dystrophy (EDMD). Through a combination of theory and experiment, we show here that a simple reaction-diffusion model explains the self-assembly of emerin nanodomains. Our model yields quantitative agreement with experimental observations on the size and occupancy of emerin nanodomains for wild-type emerin and EDMD-associated mutations of emerin, with and without applied forces, and allows successful prediction of emerin diffusion coefficients from observations of the overall properties of emerin nanodomains. Our results provide a physical understanding of EDMD-associated defects in emerin organization in terms of changes in key reaction and diffusion properties of emerin and its nuclear binding partners.http://doi.org/10.1103/PhysRevResearch.7.L012019 |
| spellingShingle | Carlos D. Alas Liying Wu Fabien Pinaud Christoph A. Haselwandter Diffusion-driven self-assembly of emerin nanodomains at the nuclear envelope Physical Review Research |
| title | Diffusion-driven self-assembly of emerin nanodomains at the nuclear envelope |
| title_full | Diffusion-driven self-assembly of emerin nanodomains at the nuclear envelope |
| title_fullStr | Diffusion-driven self-assembly of emerin nanodomains at the nuclear envelope |
| title_full_unstemmed | Diffusion-driven self-assembly of emerin nanodomains at the nuclear envelope |
| title_short | Diffusion-driven self-assembly of emerin nanodomains at the nuclear envelope |
| title_sort | diffusion driven self assembly of emerin nanodomains at the nuclear envelope |
| url | http://doi.org/10.1103/PhysRevResearch.7.L012019 |
| work_keys_str_mv | AT carlosdalas diffusiondrivenselfassemblyofemerinnanodomainsatthenuclearenvelope AT liyingwu diffusiondrivenselfassemblyofemerinnanodomainsatthenuclearenvelope AT fabienpinaud diffusiondrivenselfassemblyofemerinnanodomainsatthenuclearenvelope AT christophahaselwandter diffusiondrivenselfassemblyofemerinnanodomainsatthenuclearenvelope |