Oxidative Stress in Lead and Cadmium Toxicity and Its Amelioration
Oxidative stress has been implicated to play a role, at least in part, in pathogenesis of many disease conditions and toxicities in animals. Overproduction of reactive oxygen species and free radicals beyond the cells intrinsic capacity to neutralize following xenobiotics exposure leads to a state o...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Veterinary Medicine International |
| Online Access: | http://dx.doi.org/10.4061/2011/457327 |
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| author | R. C. Patra Amiya K. Rautray D. Swarup |
| author_facet | R. C. Patra Amiya K. Rautray D. Swarup |
| author_sort | R. C. Patra |
| collection | DOAJ |
| description | Oxidative stress has been implicated to play a role, at least in part, in pathogenesis of many disease conditions and toxicities in animals. Overproduction of reactive oxygen species and free radicals beyond the cells intrinsic capacity to neutralize following xenobiotics exposure leads to a state of oxidative stress and resultant damages of lipids, protein, and DNA. Lead and cadmium are the common environmental heavy metal pollutants and have widespread distribution. Both natural and anthropogenic sources including mining, smelting, and other industrial processes are responsible for human and animal exposure. These pollutants, many a times, are copollutants leading to concurrent exposure to living beings and resultant synergistic deleterious health effects. Several mechanisms have been explained for the damaging effects on the body system. Of late, oxidative stress has been implicated in the pathogenesis of the lead- and cadmium-induced pathotoxicity. Several ameliorative measures to counteract the oxidative damage to the body system aftermath or during exposure to these toxicants have been assessed with the use of antioxidants. The present review focuses on mechanism of lead- and cadmium-induced oxidate damages and the ameliorative measures to counteract the oxidative damage and pathotoxicity with the use of supplemented antioxidants for their beneficial effects. |
| format | Article |
| id | doaj-art-650272d1a5e1477fb7841ba867a780bd |
| institution | Kabale University |
| issn | 2042-0048 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Veterinary Medicine International |
| spelling | doaj-art-650272d1a5e1477fb7841ba867a780bd2025-02-03T06:11:02ZengWileyVeterinary Medicine International2042-00482011-01-01201110.4061/2011/457327457327Oxidative Stress in Lead and Cadmium Toxicity and Its AmeliorationR. C. Patra0Amiya K. Rautray1D. Swarup2Department of Medicine, College of Veterinary Science and Animal Husbandry, Orissa University of Agriculture and Technology, Bhubaneswar 751003, IndiaDepartment of Medicine, College of Veterinary Science and Animal Husbandry, Orissa University of Agriculture and Technology, Bhubaneswar 751003, IndiaDivision of Medicine, Indian Veterinary Research Institute, Izatnagar 243122, IndiaOxidative stress has been implicated to play a role, at least in part, in pathogenesis of many disease conditions and toxicities in animals. Overproduction of reactive oxygen species and free radicals beyond the cells intrinsic capacity to neutralize following xenobiotics exposure leads to a state of oxidative stress and resultant damages of lipids, protein, and DNA. Lead and cadmium are the common environmental heavy metal pollutants and have widespread distribution. Both natural and anthropogenic sources including mining, smelting, and other industrial processes are responsible for human and animal exposure. These pollutants, many a times, are copollutants leading to concurrent exposure to living beings and resultant synergistic deleterious health effects. Several mechanisms have been explained for the damaging effects on the body system. Of late, oxidative stress has been implicated in the pathogenesis of the lead- and cadmium-induced pathotoxicity. Several ameliorative measures to counteract the oxidative damage to the body system aftermath or during exposure to these toxicants have been assessed with the use of antioxidants. The present review focuses on mechanism of lead- and cadmium-induced oxidate damages and the ameliorative measures to counteract the oxidative damage and pathotoxicity with the use of supplemented antioxidants for their beneficial effects.http://dx.doi.org/10.4061/2011/457327 |
| spellingShingle | R. C. Patra Amiya K. Rautray D. Swarup Oxidative Stress in Lead and Cadmium Toxicity and Its Amelioration Veterinary Medicine International |
| title | Oxidative Stress in Lead and Cadmium Toxicity and Its Amelioration |
| title_full | Oxidative Stress in Lead and Cadmium Toxicity and Its Amelioration |
| title_fullStr | Oxidative Stress in Lead and Cadmium Toxicity and Its Amelioration |
| title_full_unstemmed | Oxidative Stress in Lead and Cadmium Toxicity and Its Amelioration |
| title_short | Oxidative Stress in Lead and Cadmium Toxicity and Its Amelioration |
| title_sort | oxidative stress in lead and cadmium toxicity and its amelioration |
| url | http://dx.doi.org/10.4061/2011/457327 |
| work_keys_str_mv | AT rcpatra oxidativestressinleadandcadmiumtoxicityanditsamelioration AT amiyakrautray oxidativestressinleadandcadmiumtoxicityanditsamelioration AT dswarup oxidativestressinleadandcadmiumtoxicityanditsamelioration |