Dysregulation of c-Jun (JUN) and FBJ murine osteosarcoma viral oncogene homolog B (FOSB) in obese people and their predictive values for metabolic syndrome
The incidences of metabolic syndrome (MetS), denoting insulin resistance-associated various metabolic disorders, are increasing. This study aimed to identify new biomarkers for predicting MetS and provide a novel diagnostic approach. Herein, the expression profiles of c-Jun (JUN) and FBJ murine oste...
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The Japan Endocrine Society
2024-12-01
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| Series: | Endocrine Journal |
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| Online Access: | https://www.jstage.jst.go.jp/article/endocrj/71/12/71_EJ24-0256/_html/-char/en |
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| author | Chenxi Yang Yi Chen Guangfeng Tang Tongtong Shen Li Li |
| author_facet | Chenxi Yang Yi Chen Guangfeng Tang Tongtong Shen Li Li |
| author_sort | Chenxi Yang |
| collection | DOAJ |
| description | The incidences of metabolic syndrome (MetS), denoting insulin resistance-associated various metabolic disorders, are increasing. This study aimed to identify new biomarkers for predicting MetS and provide a novel diagnostic approach. Herein, the expression profiles of c-Jun (JUN) and FBJ murine osteosarcoma viral oncogene homolog B (FOSB) in individuals with obesity and patients with MetS from the Gene Expression Omnibus database. Quantitative reverse transcription polymerase chain reaction (RT-qPCR) was used to evaluate the messenger RNA levels of JUN and FOSB in the peripheral blood of healthy volunteers (lean and obese) and patients with MetS (lean and obese), along with that in the adipose tissue and peripheral blood of obese mouse model. Furthermore, receiver operating characteristic (ROC) curve and logistic regression analyses were performed to determine the diagnostic value of JUN and FOSB in MetS. The expression profiles and RT-qPCR results showed that JUN and FOSB were highly expressed in individuals with obesity, obese mouse models, and patients with MetS. The ROC analysis results showed an area under the curve values of 0.872 and 0.879 for JUN, 0.802 and 0.962 for FOSB, and 0.946 and 0.979 for JUN–FOSB in the lean group and the group with obesity, respectively, in predicting MetS. Logistic regression analysis showed that the p-values of both JUN and FOSB as MetS-affecting factors were <0.05. Altogether, the findings of this study indicate that both JUN and FOSB, abnormally expressed in individuals with obesity, are good biomarkers of MetS. |
| format | Article |
| id | doaj-art-64f9361c9d0a42eab21a69d865d17d4d |
| institution | Kabale University |
| issn | 1348-4540 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | The Japan Endocrine Society |
| record_format | Article |
| series | Endocrine Journal |
| spelling | doaj-art-64f9361c9d0a42eab21a69d865d17d4d2025-01-22T05:34:07ZengThe Japan Endocrine SocietyEndocrine Journal1348-45402024-12-0171121157116310.1507/endocrj.EJ24-0256endocrjDysregulation of c-Jun (JUN) and FBJ murine osteosarcoma viral oncogene homolog B (FOSB) in obese people and their predictive values for metabolic syndromeChenxi Yang0Yi Chen1Guangfeng Tang2Tongtong Shen3Li Li4Department of Endocrinology, Xi’an Baoshi Flower Changqing Hospital (Changqing Oilfield Staff Hospital), Xi’an 710201, ChinaMedical Insurance Department, The Sixth People’s Hospital of Deyang City, Deyang 618000, ChinaEndocrinology Department, The Affiliated Chuzhou Hospital of Anhui Medical University, Chuzhou 239001, ChinaCardiovascular Medicine, The Affiliated Chuzhou Hospital of Anhui Medical University, Chuzhou 239001, ChinaDepartment of Obstetrics and Gynecology, Taishan Vocational College of Nursing, Taian 271000, ChinaThe incidences of metabolic syndrome (MetS), denoting insulin resistance-associated various metabolic disorders, are increasing. This study aimed to identify new biomarkers for predicting MetS and provide a novel diagnostic approach. Herein, the expression profiles of c-Jun (JUN) and FBJ murine osteosarcoma viral oncogene homolog B (FOSB) in individuals with obesity and patients with MetS from the Gene Expression Omnibus database. Quantitative reverse transcription polymerase chain reaction (RT-qPCR) was used to evaluate the messenger RNA levels of JUN and FOSB in the peripheral blood of healthy volunteers (lean and obese) and patients with MetS (lean and obese), along with that in the adipose tissue and peripheral blood of obese mouse model. Furthermore, receiver operating characteristic (ROC) curve and logistic regression analyses were performed to determine the diagnostic value of JUN and FOSB in MetS. The expression profiles and RT-qPCR results showed that JUN and FOSB were highly expressed in individuals with obesity, obese mouse models, and patients with MetS. The ROC analysis results showed an area under the curve values of 0.872 and 0.879 for JUN, 0.802 and 0.962 for FOSB, and 0.946 and 0.979 for JUN–FOSB in the lean group and the group with obesity, respectively, in predicting MetS. Logistic regression analysis showed that the p-values of both JUN and FOSB as MetS-affecting factors were <0.05. Altogether, the findings of this study indicate that both JUN and FOSB, abnormally expressed in individuals with obesity, are good biomarkers of MetS.https://www.jstage.jst.go.jp/article/endocrj/71/12/71_EJ24-0256/_html/-char/enobesitymetabolic syndromediagnosisc-jun (jun)fbj murine osteosarcoma viral oncogene homolog b (fosb) |
| spellingShingle | Chenxi Yang Yi Chen Guangfeng Tang Tongtong Shen Li Li Dysregulation of c-Jun (JUN) and FBJ murine osteosarcoma viral oncogene homolog B (FOSB) in obese people and their predictive values for metabolic syndrome Endocrine Journal obesity metabolic syndrome diagnosis c-jun (jun) fbj murine osteosarcoma viral oncogene homolog b (fosb) |
| title | Dysregulation of c-Jun (JUN) and FBJ murine osteosarcoma viral oncogene homolog B (FOSB) in obese people and their predictive values for metabolic syndrome |
| title_full | Dysregulation of c-Jun (JUN) and FBJ murine osteosarcoma viral oncogene homolog B (FOSB) in obese people and their predictive values for metabolic syndrome |
| title_fullStr | Dysregulation of c-Jun (JUN) and FBJ murine osteosarcoma viral oncogene homolog B (FOSB) in obese people and their predictive values for metabolic syndrome |
| title_full_unstemmed | Dysregulation of c-Jun (JUN) and FBJ murine osteosarcoma viral oncogene homolog B (FOSB) in obese people and their predictive values for metabolic syndrome |
| title_short | Dysregulation of c-Jun (JUN) and FBJ murine osteosarcoma viral oncogene homolog B (FOSB) in obese people and their predictive values for metabolic syndrome |
| title_sort | dysregulation of c jun jun and fbj murine osteosarcoma viral oncogene homolog b fosb in obese people and their predictive values for metabolic syndrome |
| topic | obesity metabolic syndrome diagnosis c-jun (jun) fbj murine osteosarcoma viral oncogene homolog b (fosb) |
| url | https://www.jstage.jst.go.jp/article/endocrj/71/12/71_EJ24-0256/_html/-char/en |
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