Glomerular Filtration Rate and/or Ratio of Urine Albumin to Creatinine as Markers for Diabetic Retinopathy: A Ten-Year Follow-Up Study
Aims. To determine the relationship between diabetic nephropathy and diabetic retinopathy on a population of type 2 diabetes mellitus patients. Methods. A prospective ten-year follow-up population-based study. We determined differences between estimated glomerular filtration rate (eGFR) using the ch...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2018/5637130 |
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| author | Pedro Romero-Aroca Marc Baget-Bernaldiz Raul Navarro-Gil Antonio Moreno-Ribas Aida Valls-Mateu Ramon Sagarra-Alamo Joan F. Barrot-De La Puente Xavier Mundet-Tuduri |
| author_facet | Pedro Romero-Aroca Marc Baget-Bernaldiz Raul Navarro-Gil Antonio Moreno-Ribas Aida Valls-Mateu Ramon Sagarra-Alamo Joan F. Barrot-De La Puente Xavier Mundet-Tuduri |
| author_sort | Pedro Romero-Aroca |
| collection | DOAJ |
| description | Aims. To determine the relationship between diabetic nephropathy and diabetic retinopathy on a population of type 2 diabetes mellitus patients. Methods. A prospective ten-year follow-up population-based study. We determined differences between estimated glomerular filtration rate (eGFR) using the chronic kidney disease epidemiology collaboration equation and urine albumin to creatinine ratio. Results. Annual incidence of any-DR was 8.21 ± 0.60% (7.06%–8.92%), sight-threatening diabetic retinopathy (STDR) was 2.65 ± 0.14% (2.48%–2.88%), and diabetic macular edema (DME) was 2.21 ± 0.18% (2%–2.49%). Renal study results were as follows: UACR > 30 mg/g had an annual incidence of 7.02 ± 0.05% (6.97%–7.09%), eGFR < 60 ml/min/1.73 m2 incidence was 5.89 ± 0.12% (5.70%–6.13%). Cox’s proportional regression analysis of DR incidence shows that renal function studied by eGFR < 60 ml/min/1.73 m2 was less significant (p=0.04, HR 1.223, 1.098–1.201) than UACR ≥ 300 mg/g (p<0.001, HR 1.485, 1.103–1.548). The study of STDR shows that eGFR < 60 ml/min/1.73 m2 was significant (p=0.02, HR 1.890, 1.267–2.820), UACR ≥ 300 mg/g (p<0.001, HR 2.448, 1.595–3.757), and DME shows that eGFR < 60 ml/min/1.73 m2 was significant (p=0.02, HR 1.920, 1.287–2.864) and UACR ≥ 300 mg/g (p<0.001, HR 2.432, 1.584–3.732). Conclusions. The UACR has a better association with diabetic retinopathy than the eGFR, although both are important risk factors for diabetic retinopathy. |
| format | Article |
| id | doaj-art-64e81d2a184d4138a6c35a5deedbc42c |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-64e81d2a184d4138a6c35a5deedbc42c2025-02-03T01:11:33ZengWileyJournal of Diabetes Research2314-67452314-67532018-01-01201810.1155/2018/56371305637130Glomerular Filtration Rate and/or Ratio of Urine Albumin to Creatinine as Markers for Diabetic Retinopathy: A Ten-Year Follow-Up StudyPedro Romero-Aroca0Marc Baget-Bernaldiz1Raul Navarro-Gil2Antonio Moreno-Ribas3Aida Valls-Mateu4Ramon Sagarra-Alamo5Joan F. Barrot-De La Puente6Xavier Mundet-Tuduri7Ophthalmology Service, University Hospital Sant Joan, Institut de Investigacio Sanitaria Pere Virgili (IISPV), Universitat Rovira & Virgili, Reus, SpainOphthalmology Service, University Hospital Sant Joan, Institut de Investigacio Sanitaria Pere Virgili (IISPV), Universitat Rovira & Virgili, Reus, SpainOphthalmology Service, University Hospital Sant Joan, Institut de Investigacio Sanitaria Pere Virgili (IISPV), Universitat Rovira & Virgili, Reus, SpainDepartment of Computer Engineering and Mathematics, Universitat Rovira & Virgili, Reus, SpainDepartment of Computer Engineering and Mathematics, Universitat Rovira & Virgili, Reus, SpainHealth Care Area Reus-Priorat, Institut Catala de la Salut (ICS), Institut de Investigació Sanitària Pere Virgili (IISPV), Universitat Rovira & Virgili, Reus, SpainHealth Care Area Jordi Nadal de Salt (ICS), Unitat de Suport a la Recerca Barcelona Ciutat, Institut Universitari d’Investigacio en Atencio Primaria Jordi Gol (IDIAP Jordi Gol), Barcelona, SpainUnitat de Suport a la Recerca Barcelona Ciutat, Institut Universitari d’Investigacio en Atencio Primaria Jordi Gol (IDIAP Jordi Gol), Universitat Autonoma de Barcelona, Bellaterra, SpainAims. To determine the relationship between diabetic nephropathy and diabetic retinopathy on a population of type 2 diabetes mellitus patients. Methods. A prospective ten-year follow-up population-based study. We determined differences between estimated glomerular filtration rate (eGFR) using the chronic kidney disease epidemiology collaboration equation and urine albumin to creatinine ratio. Results. Annual incidence of any-DR was 8.21 ± 0.60% (7.06%–8.92%), sight-threatening diabetic retinopathy (STDR) was 2.65 ± 0.14% (2.48%–2.88%), and diabetic macular edema (DME) was 2.21 ± 0.18% (2%–2.49%). Renal study results were as follows: UACR > 30 mg/g had an annual incidence of 7.02 ± 0.05% (6.97%–7.09%), eGFR < 60 ml/min/1.73 m2 incidence was 5.89 ± 0.12% (5.70%–6.13%). Cox’s proportional regression analysis of DR incidence shows that renal function studied by eGFR < 60 ml/min/1.73 m2 was less significant (p=0.04, HR 1.223, 1.098–1.201) than UACR ≥ 300 mg/g (p<0.001, HR 1.485, 1.103–1.548). The study of STDR shows that eGFR < 60 ml/min/1.73 m2 was significant (p=0.02, HR 1.890, 1.267–2.820), UACR ≥ 300 mg/g (p<0.001, HR 2.448, 1.595–3.757), and DME shows that eGFR < 60 ml/min/1.73 m2 was significant (p=0.02, HR 1.920, 1.287–2.864) and UACR ≥ 300 mg/g (p<0.001, HR 2.432, 1.584–3.732). Conclusions. The UACR has a better association with diabetic retinopathy than the eGFR, although both are important risk factors for diabetic retinopathy.http://dx.doi.org/10.1155/2018/5637130 |
| spellingShingle | Pedro Romero-Aroca Marc Baget-Bernaldiz Raul Navarro-Gil Antonio Moreno-Ribas Aida Valls-Mateu Ramon Sagarra-Alamo Joan F. Barrot-De La Puente Xavier Mundet-Tuduri Glomerular Filtration Rate and/or Ratio of Urine Albumin to Creatinine as Markers for Diabetic Retinopathy: A Ten-Year Follow-Up Study Journal of Diabetes Research |
| title | Glomerular Filtration Rate and/or Ratio of Urine Albumin to Creatinine as Markers for Diabetic Retinopathy: A Ten-Year Follow-Up Study |
| title_full | Glomerular Filtration Rate and/or Ratio of Urine Albumin to Creatinine as Markers for Diabetic Retinopathy: A Ten-Year Follow-Up Study |
| title_fullStr | Glomerular Filtration Rate and/or Ratio of Urine Albumin to Creatinine as Markers for Diabetic Retinopathy: A Ten-Year Follow-Up Study |
| title_full_unstemmed | Glomerular Filtration Rate and/or Ratio of Urine Albumin to Creatinine as Markers for Diabetic Retinopathy: A Ten-Year Follow-Up Study |
| title_short | Glomerular Filtration Rate and/or Ratio of Urine Albumin to Creatinine as Markers for Diabetic Retinopathy: A Ten-Year Follow-Up Study |
| title_sort | glomerular filtration rate and or ratio of urine albumin to creatinine as markers for diabetic retinopathy a ten year follow up study |
| url | http://dx.doi.org/10.1155/2018/5637130 |
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