Association Analysis of ULK1 with Crohn’s Disease in a New Zealand Population
The gene ULK1 is an excellent candidate for Crohn’s disease (CD) due to its role in autophagy. A recent study provided evidence for the involvement of ULK1 in the pathogenesis of CD (Henckaerts et al., 2011). We attempted to validate this association, using a candidate gene SNP study of ULK1 in CD....
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2012/715309 |
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| author | Angharad R. Morgan Wen-Jiun Lam Dug-Yeo Han Alan G. Fraser Lynnette R. Ferguson |
| author_facet | Angharad R. Morgan Wen-Jiun Lam Dug-Yeo Han Alan G. Fraser Lynnette R. Ferguson |
| author_sort | Angharad R. Morgan |
| collection | DOAJ |
| description | The gene ULK1 is an excellent candidate for Crohn’s disease (CD) due to its role in autophagy. A recent study provided evidence for the involvement of ULK1 in the pathogenesis of CD (Henckaerts et al., 2011). We attempted to validate this association, using a candidate gene SNP study of ULK1 in CD. We identified tagging SNPs and genotyped these SNPs using the Sequenom platform in a Caucasian New Zealand dataset consisting of 406 CD patients and 638 controls. In this sample, we were able to demonstrate an association between CD and several different ULK1 SNPs and haplotypes. Phenotypic analysis showed an association with age of diagnosis 17–40 years and inflammatory behaviour. The findings of this study provide evidence to suggest that genetic variation in ULK1 may play a role in interindividual differences in CD susceptibility and clinical outcome. |
| format | Article |
| id | doaj-art-64e3b0dbf3154d6389ed7ef42b319e63 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-64e3b0dbf3154d6389ed7ef42b319e632025-02-03T05:57:12ZengWileyGastroenterology Research and Practice1687-61211687-630X2012-01-01201210.1155/2012/715309715309Association Analysis of ULK1 with Crohn’s Disease in a New Zealand PopulationAngharad R. Morgan0Wen-Jiun Lam1Dug-Yeo Han2Alan G. Fraser3Lynnette R. Ferguson4Department of Nutrition, Faculty of Medical and Health Sciences, The University of Auckland, Grafton, Auckland 1142, New ZealandDepartment of Nutrition, Faculty of Medical and Health Sciences, The University of Auckland, Grafton, Auckland 1142, New ZealandDepartment of Nutrition, Faculty of Medical and Health Sciences, The University of Auckland, Grafton, Auckland 1142, New ZealandNutrigenomics New Zealand, New ZealandDepartment of Nutrition, Faculty of Medical and Health Sciences, The University of Auckland, Grafton, Auckland 1142, New ZealandThe gene ULK1 is an excellent candidate for Crohn’s disease (CD) due to its role in autophagy. A recent study provided evidence for the involvement of ULK1 in the pathogenesis of CD (Henckaerts et al., 2011). We attempted to validate this association, using a candidate gene SNP study of ULK1 in CD. We identified tagging SNPs and genotyped these SNPs using the Sequenom platform in a Caucasian New Zealand dataset consisting of 406 CD patients and 638 controls. In this sample, we were able to demonstrate an association between CD and several different ULK1 SNPs and haplotypes. Phenotypic analysis showed an association with age of diagnosis 17–40 years and inflammatory behaviour. The findings of this study provide evidence to suggest that genetic variation in ULK1 may play a role in interindividual differences in CD susceptibility and clinical outcome.http://dx.doi.org/10.1155/2012/715309 |
| spellingShingle | Angharad R. Morgan Wen-Jiun Lam Dug-Yeo Han Alan G. Fraser Lynnette R. Ferguson Association Analysis of ULK1 with Crohn’s Disease in a New Zealand Population Gastroenterology Research and Practice |
| title | Association Analysis of ULK1 with Crohn’s Disease in a New Zealand Population |
| title_full | Association Analysis of ULK1 with Crohn’s Disease in a New Zealand Population |
| title_fullStr | Association Analysis of ULK1 with Crohn’s Disease in a New Zealand Population |
| title_full_unstemmed | Association Analysis of ULK1 with Crohn’s Disease in a New Zealand Population |
| title_short | Association Analysis of ULK1 with Crohn’s Disease in a New Zealand Population |
| title_sort | association analysis of ulk1 with crohn s disease in a new zealand population |
| url | http://dx.doi.org/10.1155/2012/715309 |
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