Bioactive Steroids with Structural Diversity from the South China Sea Soft Coral <i>Lobophytum</i> sp. and Sponge <i>Xestospongia</i> sp.
A chemical investigation of the soft coral <i>Lobophytum</i> sp. and the sponge <i>Xestospongia</i> sp. from the South China Sea led to the isolation of five steroids, including two new compounds (<b>1</b> and <b>4</b>) and one known natural product (&...
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MDPI AG
2025-01-01
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| author | Lin-Mao Ke Zi-Ru Zhang Song-Wei Li Yan-Bo Zeng Ming-Zhi Su Yue-Wei Guo |
| author_facet | Lin-Mao Ke Zi-Ru Zhang Song-Wei Li Yan-Bo Zeng Ming-Zhi Su Yue-Wei Guo |
| author_sort | Lin-Mao Ke |
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| description | A chemical investigation of the soft coral <i>Lobophytum</i> sp. and the sponge <i>Xestospongia</i> sp. from the South China Sea led to the isolation of five steroids, including two new compounds (<b>1</b> and <b>4</b>) and one known natural product (<b>3</b>). Compounds <b>1</b>–<b>3</b> were derived from the soft coral <i>Lobophytum</i> sp., while <b>4</b> and <b>5</b> were obtained from the sponge <i>Xestospongia</i> sp. The structures of these compounds were determined by extensive spectroscopic analysis, the time-dependent density functional theory–electronic circular dichroism (TDDFT-ECD) calculation method, and comparison with the spectral data previously reported in the literature. The antibacterial and anti-inflammatory activities of isolated compounds were evaluated in vitro. Compounds <b>1</b>–<b>3</b>, <b>4</b>, and <b>5</b> exhibited weak antibacterial activity against vancomycin-resistant <i>Enterococcus faecium</i> G1, <i>Streptococcus parauberis</i> KSP28, <i>Photobacterium damselae</i> FP2244, <i>Lactococcus garvieae</i> FP5245, and <i>Pseudomonas aeruginosa</i> ZJ028. Moreover, compound <b>3</b> showed significant anti-inflammatory activity by inhibiting lipopolysaccharide (LPS)-induced NO production in RAW 264.7 cells, with an IC<sub>50</sub> value of 13.48 μM. |
| format | Article |
| id | doaj-art-64dadf4d0d7f48ff8519545b108d095f |
| institution | Kabale University |
| issn | 1660-3397 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj-art-64dadf4d0d7f48ff8519545b108d095f2025-01-24T13:39:34ZengMDPI AGMarine Drugs1660-33972025-01-012313610.3390/md23010036Bioactive Steroids with Structural Diversity from the South China Sea Soft Coral <i>Lobophytum</i> sp. and Sponge <i>Xestospongia</i> sp.Lin-Mao Ke0Zi-Ru Zhang1Song-Wei Li2Yan-Bo Zeng3Ming-Zhi Su4Yue-Wei Guo5Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai 264117, ChinaShandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai 264117, ChinaSchool of Medicine, Shanghai University, Shanghai 200444, ChinaHainan Provincial Key Laboratory for Functional Components Research and Utilization of Marine Bio-Resources, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, ChinaShandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai 264117, ChinaShandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai 264117, ChinaA chemical investigation of the soft coral <i>Lobophytum</i> sp. and the sponge <i>Xestospongia</i> sp. from the South China Sea led to the isolation of five steroids, including two new compounds (<b>1</b> and <b>4</b>) and one known natural product (<b>3</b>). Compounds <b>1</b>–<b>3</b> were derived from the soft coral <i>Lobophytum</i> sp., while <b>4</b> and <b>5</b> were obtained from the sponge <i>Xestospongia</i> sp. The structures of these compounds were determined by extensive spectroscopic analysis, the time-dependent density functional theory–electronic circular dichroism (TDDFT-ECD) calculation method, and comparison with the spectral data previously reported in the literature. The antibacterial and anti-inflammatory activities of isolated compounds were evaluated in vitro. Compounds <b>1</b>–<b>3</b>, <b>4</b>, and <b>5</b> exhibited weak antibacterial activity against vancomycin-resistant <i>Enterococcus faecium</i> G1, <i>Streptococcus parauberis</i> KSP28, <i>Photobacterium damselae</i> FP2244, <i>Lactococcus garvieae</i> FP5245, and <i>Pseudomonas aeruginosa</i> ZJ028. Moreover, compound <b>3</b> showed significant anti-inflammatory activity by inhibiting lipopolysaccharide (LPS)-induced NO production in RAW 264.7 cells, with an IC<sub>50</sub> value of 13.48 μM.https://www.mdpi.com/1660-3397/23/1/36soft coralspongeoxygenated steroidsantibacterial activityanti-inflammatory activity |
| spellingShingle | Lin-Mao Ke Zi-Ru Zhang Song-Wei Li Yan-Bo Zeng Ming-Zhi Su Yue-Wei Guo Bioactive Steroids with Structural Diversity from the South China Sea Soft Coral <i>Lobophytum</i> sp. and Sponge <i>Xestospongia</i> sp. Marine Drugs soft coral sponge oxygenated steroids antibacterial activity anti-inflammatory activity |
| title | Bioactive Steroids with Structural Diversity from the South China Sea Soft Coral <i>Lobophytum</i> sp. and Sponge <i>Xestospongia</i> sp. |
| title_full | Bioactive Steroids with Structural Diversity from the South China Sea Soft Coral <i>Lobophytum</i> sp. and Sponge <i>Xestospongia</i> sp. |
| title_fullStr | Bioactive Steroids with Structural Diversity from the South China Sea Soft Coral <i>Lobophytum</i> sp. and Sponge <i>Xestospongia</i> sp. |
| title_full_unstemmed | Bioactive Steroids with Structural Diversity from the South China Sea Soft Coral <i>Lobophytum</i> sp. and Sponge <i>Xestospongia</i> sp. |
| title_short | Bioactive Steroids with Structural Diversity from the South China Sea Soft Coral <i>Lobophytum</i> sp. and Sponge <i>Xestospongia</i> sp. |
| title_sort | bioactive steroids with structural diversity from the south china sea soft coral i lobophytum i sp and sponge i xestospongia i sp |
| topic | soft coral sponge oxygenated steroids antibacterial activity anti-inflammatory activity |
| url | https://www.mdpi.com/1660-3397/23/1/36 |
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