Bioactive Steroids with Structural Diversity from the South China Sea Soft Coral <i>Lobophytum</i> sp. and Sponge <i>Xestospongia</i> sp.
A chemical investigation of the soft coral <i>Lobophytum</i> sp. and the sponge <i>Xestospongia</i> sp. from the South China Sea led to the isolation of five steroids, including two new compounds (<b>1</b> and <b>4</b>) and one known natural product (&...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
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| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1660-3397/23/1/36 |
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| Summary: | A chemical investigation of the soft coral <i>Lobophytum</i> sp. and the sponge <i>Xestospongia</i> sp. from the South China Sea led to the isolation of five steroids, including two new compounds (<b>1</b> and <b>4</b>) and one known natural product (<b>3</b>). Compounds <b>1</b>–<b>3</b> were derived from the soft coral <i>Lobophytum</i> sp., while <b>4</b> and <b>5</b> were obtained from the sponge <i>Xestospongia</i> sp. The structures of these compounds were determined by extensive spectroscopic analysis, the time-dependent density functional theory–electronic circular dichroism (TDDFT-ECD) calculation method, and comparison with the spectral data previously reported in the literature. The antibacterial and anti-inflammatory activities of isolated compounds were evaluated in vitro. Compounds <b>1</b>–<b>3</b>, <b>4</b>, and <b>5</b> exhibited weak antibacterial activity against vancomycin-resistant <i>Enterococcus faecium</i> G1, <i>Streptococcus parauberis</i> KSP28, <i>Photobacterium damselae</i> FP2244, <i>Lactococcus garvieae</i> FP5245, and <i>Pseudomonas aeruginosa</i> ZJ028. Moreover, compound <b>3</b> showed significant anti-inflammatory activity by inhibiting lipopolysaccharide (LPS)-induced NO production in RAW 264.7 cells, with an IC<sub>50</sub> value of 13.48 μM. |
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| ISSN: | 1660-3397 |