Immunopeptidomics for autoimmunity: unlocking the chamber of immune secrets
Abstract T cells mediate pathogenesis of several autoimmune disorders by recognizing self-epitopes presented on Major Histocompatibility Complex (MHC) or Human Leukocyte Antigen (HLA) complex. The majority of autoantigens presented to T cells in various autoimmune disorders are not known, which has...
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| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | npj Systems Biology and Applications |
| Online Access: | https://doi.org/10.1038/s41540-024-00482-x |
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| author | Sanya Arshad Benjamin Cameron Alok V. Joglekar |
| author_facet | Sanya Arshad Benjamin Cameron Alok V. Joglekar |
| author_sort | Sanya Arshad |
| collection | DOAJ |
| description | Abstract T cells mediate pathogenesis of several autoimmune disorders by recognizing self-epitopes presented on Major Histocompatibility Complex (MHC) or Human Leukocyte Antigen (HLA) complex. The majority of autoantigens presented to T cells in various autoimmune disorders are not known, which has impeded autoantigen identification. Recent advances in immunopeptidomics have started to unravel the repertoire of antigenic epitopes presented on MHC. In several autoimmune diseases, immunopeptidomics has led to the identification of novel autoantigens and has enhanced our understanding of the mechanisms behind autoimmunity. Especially, immunopeptidomics has provided key evidence to explain the genetic risk posed by HLA alleles. In this review, we shed light on how immunopeptidomics can be leveraged to discover potential autoantigens. We highlight the application of immunopeptidomics in Type 1 Diabetes (T1D), Systemic Lupus Erythematosus (SLE), and Rheumatoid Arthritis (RA). Finally, we highlight the practical considerations of implementing immunopeptidomics successfully and the technical challenges that need to be addressed. Overall, this review will provide an important context for using immunopeptidomics for understanding autoimmunity. |
| format | Article |
| id | doaj-art-64c639476c0047cca4e06265ceff56a9 |
| institution | Kabale University |
| issn | 2056-7189 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Systems Biology and Applications |
| spelling | doaj-art-64c639476c0047cca4e06265ceff56a92025-01-26T12:39:34ZengNature Portfolionpj Systems Biology and Applications2056-71892025-01-0111111110.1038/s41540-024-00482-xImmunopeptidomics for autoimmunity: unlocking the chamber of immune secretsSanya Arshad0Benjamin Cameron1Alok V. Joglekar2Department of Immunology, University of PittsburghDepartment of Immunology, University of PittsburghDepartment of Immunology, University of PittsburghAbstract T cells mediate pathogenesis of several autoimmune disorders by recognizing self-epitopes presented on Major Histocompatibility Complex (MHC) or Human Leukocyte Antigen (HLA) complex. The majority of autoantigens presented to T cells in various autoimmune disorders are not known, which has impeded autoantigen identification. Recent advances in immunopeptidomics have started to unravel the repertoire of antigenic epitopes presented on MHC. In several autoimmune diseases, immunopeptidomics has led to the identification of novel autoantigens and has enhanced our understanding of the mechanisms behind autoimmunity. Especially, immunopeptidomics has provided key evidence to explain the genetic risk posed by HLA alleles. In this review, we shed light on how immunopeptidomics can be leveraged to discover potential autoantigens. We highlight the application of immunopeptidomics in Type 1 Diabetes (T1D), Systemic Lupus Erythematosus (SLE), and Rheumatoid Arthritis (RA). Finally, we highlight the practical considerations of implementing immunopeptidomics successfully and the technical challenges that need to be addressed. Overall, this review will provide an important context for using immunopeptidomics for understanding autoimmunity.https://doi.org/10.1038/s41540-024-00482-x |
| spellingShingle | Sanya Arshad Benjamin Cameron Alok V. Joglekar Immunopeptidomics for autoimmunity: unlocking the chamber of immune secrets npj Systems Biology and Applications |
| title | Immunopeptidomics for autoimmunity: unlocking the chamber of immune secrets |
| title_full | Immunopeptidomics for autoimmunity: unlocking the chamber of immune secrets |
| title_fullStr | Immunopeptidomics for autoimmunity: unlocking the chamber of immune secrets |
| title_full_unstemmed | Immunopeptidomics for autoimmunity: unlocking the chamber of immune secrets |
| title_short | Immunopeptidomics for autoimmunity: unlocking the chamber of immune secrets |
| title_sort | immunopeptidomics for autoimmunity unlocking the chamber of immune secrets |
| url | https://doi.org/10.1038/s41540-024-00482-x |
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