Effect of Weight Loss on Serum Osteocalcin and Its Association with Serum Adipokines
Studies have suggested that osteocalcin, a bone formation marker, is related to body metabolism and insulin sensitivity. Whether this relation is mediated through an interaction with adipokines remains unclear. The aim of this study was to assess the effect of weight loss on serum osteocalcin and it...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2015/508532 |
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| author | Mohammed S. Albadah Hafedh Dekhil Shaffi Ahamed Shaik Mohammed A. Alsaif Mustafa Shogair Shahid Nawaz Assim A. Alfadda |
| author_facet | Mohammed S. Albadah Hafedh Dekhil Shaffi Ahamed Shaik Mohammed A. Alsaif Mustafa Shogair Shahid Nawaz Assim A. Alfadda |
| author_sort | Mohammed S. Albadah |
| collection | DOAJ |
| description | Studies have suggested that osteocalcin, a bone formation marker, is related to body metabolism and insulin sensitivity. Whether this relation is mediated through an interaction with adipokines remains unclear. The aim of this study was to assess the effect of weight loss on serum osteocalcin and its relation with three adipokines, adiponectin, chemerin, and resistin. Forty-nine obese nondiabetic males completed a four-month dietary program. Body mass index (BMI) decreased significantly from 39.7±7.6 to 37.8±7.6 (P<0.001). This was associated with significant reduction in waist circumference, fasting blood glucose, HOMA-IR, total and LDL-cholesterol, bone-specific alkaline phosphatase (BAP), and resistin (P<0.05). There was significant increase in serum adiponectin and undercarboxylated osteocalcin (uOC) (P<0.001). The changes in uOC levels were negatively correlated with changes in serum triglycerides (r=-0.51, P<0.001) and positively correlated with changes in BAP (r=0.52, P<0.001). In contrast, the changes in uOC were not correlated with changes in BMI, waist circumference, fasting blood glucose, HOMA-IR, total and LDL-cholesterol, hsCRP, vitamin D, and circulating adipokines. We concluded that the increase in serum uOC following weight loss is not related to the changes in circulating adipokines levels. |
| format | Article |
| id | doaj-art-64bafc6004fb49dda9c9b18f51ef5c78 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-64bafc6004fb49dda9c9b18f51ef5c782025-02-03T06:01:28ZengWileyInternational Journal of Endocrinology1687-83371687-83452015-01-01201510.1155/2015/508532508532Effect of Weight Loss on Serum Osteocalcin and Its Association with Serum AdipokinesMohammed S. Albadah0Hafedh Dekhil1Shaffi Ahamed Shaik2Mohammed A. Alsaif3Mustafa Shogair4Shahid Nawaz5Assim A. Alfadda6Obesity Research Center, College of Medicine, King Saud University, P.O. Box 2925 (98), Riyadh 11461, Saudi ArabiaObesity Research Center, College of Medicine, King Saud University, P.O. Box 2925 (98), Riyadh 11461, Saudi ArabiaDepartment of Family and Community Medicine, College of Medicine, King Saud University, P.O. Box 2925, Riyadh 11461, Saudi ArabiaDepartment of Community Health Sciences, College of Applied Medical Sciences, King Saud University, P.O. Box 10219, Riyadh 11433, Saudi ArabiaObesity Research Center, College of Medicine, King Saud University, P.O. Box 2925 (98), Riyadh 11461, Saudi ArabiaObesity Research Center, College of Medicine, King Saud University, P.O. Box 2925 (98), Riyadh 11461, Saudi ArabiaObesity Research Center, College of Medicine, King Saud University, P.O. Box 2925 (98), Riyadh 11461, Saudi ArabiaStudies have suggested that osteocalcin, a bone formation marker, is related to body metabolism and insulin sensitivity. Whether this relation is mediated through an interaction with adipokines remains unclear. The aim of this study was to assess the effect of weight loss on serum osteocalcin and its relation with three adipokines, adiponectin, chemerin, and resistin. Forty-nine obese nondiabetic males completed a four-month dietary program. Body mass index (BMI) decreased significantly from 39.7±7.6 to 37.8±7.6 (P<0.001). This was associated with significant reduction in waist circumference, fasting blood glucose, HOMA-IR, total and LDL-cholesterol, bone-specific alkaline phosphatase (BAP), and resistin (P<0.05). There was significant increase in serum adiponectin and undercarboxylated osteocalcin (uOC) (P<0.001). The changes in uOC levels were negatively correlated with changes in serum triglycerides (r=-0.51, P<0.001) and positively correlated with changes in BAP (r=0.52, P<0.001). In contrast, the changes in uOC were not correlated with changes in BMI, waist circumference, fasting blood glucose, HOMA-IR, total and LDL-cholesterol, hsCRP, vitamin D, and circulating adipokines. We concluded that the increase in serum uOC following weight loss is not related to the changes in circulating adipokines levels.http://dx.doi.org/10.1155/2015/508532 |
| spellingShingle | Mohammed S. Albadah Hafedh Dekhil Shaffi Ahamed Shaik Mohammed A. Alsaif Mustafa Shogair Shahid Nawaz Assim A. Alfadda Effect of Weight Loss on Serum Osteocalcin and Its Association with Serum Adipokines International Journal of Endocrinology |
| title | Effect of Weight Loss on Serum Osteocalcin and Its Association with Serum Adipokines |
| title_full | Effect of Weight Loss on Serum Osteocalcin and Its Association with Serum Adipokines |
| title_fullStr | Effect of Weight Loss on Serum Osteocalcin and Its Association with Serum Adipokines |
| title_full_unstemmed | Effect of Weight Loss on Serum Osteocalcin and Its Association with Serum Adipokines |
| title_short | Effect of Weight Loss on Serum Osteocalcin and Its Association with Serum Adipokines |
| title_sort | effect of weight loss on serum osteocalcin and its association with serum adipokines |
| url | http://dx.doi.org/10.1155/2015/508532 |
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