Probabilistic nested model selection in pharmacokinetic analysis of DCE-MRI data in animal model of cerebral tumor

Probabilistic nested model selection in pharmacokinetic analysis of DCE-MRI data in animal model of cerebral tumor

Abstract Best current practice in the analysis of dynamic contrast enhanced (DCE)-MRI is to employ a voxel-by-voxel model selection from a hierarchy of nested models. This nested model selection (NMS) assumes that the observed time-trace of contrast-agent (CA) concentration within a voxel, correspon...

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Bibliographic Details
Main Authors: Hassan Bagher-Ebadian, Stephen L. Brown, Mohammad M. Ghassemi, Prabhu C. Acharya, Indrin J. Chetty, Benjamin Movsas, James R. Ewing, Kundan Thind
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Nested Model Selection
Dynamic Contrast Enhanced MRI
Model Averaging
Unsupervised Kohonen Self Organizing Map
Physiological Tissue Characterization
Online Access:https://doi.org/10.1038/s41598-024-83306-6
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