The electroencephalography protocol for the Accelerating Medicines Partnership® Schizophrenia Program: Reliability and stability of measures
Abstract Individuals at clinical high risk for psychosis (CHR) have variable clinical outcomes and low conversion rates, limiting development of novel and personalized treatments. Moreover, given risks of antipsychotic drugs, safer effective medications for CHR individuals are needed. The Accelerati...
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Nature Portfolio
2025-06-01
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| Series: | Schizophrenia |
| Online Access: | https://doi.org/10.1038/s41537-025-00622-0 |
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| author | Daniel H. Mathalon Spero Nicholas Brian J. Roach Tashrif Billah Suzie Lavoie Thomas Whitford Holly K. Hamilton Lauren Addamo Andrey Anohkin Tristan Bekinschtein Aysenil Belger Kate Buccilli John Cahill Ricardo E. Carrión Stefano Damiani Ilvana Dzafic Bjørn H. Ebdrup Igor Izyurov Johanna Jarcho Raoul Jenni Anna Jo Sarah Kerins Clarice Lee Elizabeth A. Martin Rocio Mayol-Troncoso Margaret A. Niznikiewicz Muhammad Parvaz Oliver Pogarell Julio Prieto-Montalvo Rachel Rabin David R. Roalf Jack Rogers Dean F. Salisbury Riaz Shaik Stewart Shankman Michael C. Stevens Yi Nam Suen Nicole C. Swann Xiaochen Tang Judy L. Thompson Ivy Tso Julian Wenzel Juan Helen Zhou Jean Addington Luis Alameda Celso Arango Nicholas J. K. Breitborde Matthew R. Broome Kristin S. Cadenhead Monica E. Calkins Rolando I. Castillo-Passi Eric Yu Hai Chen Jimmy Choi Philippe Conus Cheryl M. Corcoran Barbara A. Cornblatt Covadonga M. Diaz-Caneja Lauren M. Ellman Paolo Fusar-Poli Pablo A. Gaspar Carla Gerber Louise Birkedal Glenthøj Leslie E. Horton Christy Lai Ming Hui Joseph Kambeitz Lana Kambeitz-Ilankovic Matcheri S. Keshavan Minah Kim Sung-Wan Kim Nikolaos Koutsouleris Jun Soo Kwon Kerstin Langbein Daniel Mamah Vijay A. Mittal Merete Nordentoft Godfrey D. Pearlson Jesus Perez Diana O. Perkins Albert R. Powers Fred W. Sabb Jason Schiffman Jai L. Shah Steven M. Silverstein Stefan Smesny William S. Stone Gregory P. Strauss Rachel Upthegrove Swapna K. Verma Jijun Wang Daniel H. Wolf Tianhong Zhang Sylvain Bouix Ofer Pasternak Kang-Ik K. Cho Michael J. Coleman Dominic Dwyer Angela Nunez Zailyn Tamayo Stephen J. Wood Rene S. Kahn John M. Kane Patrick D. McGorry Carrie E. Bearden Barnaby Nelson Scott W. Woods Martha E. Shenton Accelerating Medicines Partnership® Schizophrenia Program Gregory A. Light |
| author_facet | Daniel H. Mathalon Spero Nicholas Brian J. Roach Tashrif Billah Suzie Lavoie Thomas Whitford Holly K. Hamilton Lauren Addamo Andrey Anohkin Tristan Bekinschtein Aysenil Belger Kate Buccilli John Cahill Ricardo E. Carrión Stefano Damiani Ilvana Dzafic Bjørn H. Ebdrup Igor Izyurov Johanna Jarcho Raoul Jenni Anna Jo Sarah Kerins Clarice Lee Elizabeth A. Martin Rocio Mayol-Troncoso Margaret A. Niznikiewicz Muhammad Parvaz Oliver Pogarell Julio Prieto-Montalvo Rachel Rabin David R. Roalf Jack Rogers Dean F. Salisbury Riaz Shaik Stewart Shankman Michael C. Stevens Yi Nam Suen Nicole C. Swann Xiaochen Tang Judy L. Thompson Ivy Tso Julian Wenzel Juan Helen Zhou Jean Addington Luis Alameda Celso Arango Nicholas J. K. Breitborde Matthew R. Broome Kristin S. Cadenhead Monica E. Calkins Rolando I. Castillo-Passi Eric Yu Hai Chen Jimmy Choi Philippe Conus Cheryl M. Corcoran Barbara A. Cornblatt Covadonga M. Diaz-Caneja Lauren M. Ellman Paolo Fusar-Poli Pablo A. Gaspar Carla Gerber Louise Birkedal Glenthøj Leslie E. Horton Christy Lai Ming Hui Joseph Kambeitz Lana Kambeitz-Ilankovic Matcheri S. Keshavan Minah Kim Sung-Wan Kim Nikolaos Koutsouleris Jun Soo Kwon Kerstin Langbein Daniel Mamah Vijay A. Mittal Merete Nordentoft Godfrey D. Pearlson Jesus Perez Diana O. Perkins Albert R. Powers Fred W. Sabb Jason Schiffman Jai L. Shah Steven M. Silverstein Stefan Smesny William S. Stone Gregory P. Strauss Rachel Upthegrove Swapna K. Verma Jijun Wang Daniel H. Wolf Tianhong Zhang Sylvain Bouix Ofer Pasternak Kang-Ik K. Cho Michael J. Coleman Dominic Dwyer Angela Nunez Zailyn Tamayo Stephen J. Wood Rene S. Kahn John M. Kane Patrick D. McGorry Carrie E. Bearden Barnaby Nelson Scott W. Woods Martha E. Shenton Accelerating Medicines Partnership® Schizophrenia Program Gregory A. Light |
| author_sort | Daniel H. Mathalon |
| collection | DOAJ |
| description | Abstract Individuals at clinical high risk for psychosis (CHR) have variable clinical outcomes and low conversion rates, limiting development of novel and personalized treatments. Moreover, given risks of antipsychotic drugs, safer effective medications for CHR individuals are needed. The Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ) Program was launched to address this need. Based on past CHR and schizophrenia studies, AMP SCZ assessed electroencephalography (EEG)-based event-related potential (ERP), event-related oscillation (ERO), and resting EEG power spectral density (PSD) measures, including mismatch negativity (MMN), auditory and visual P300 to target (P3b) and novel (P3a) stimuli, 40-Hz auditory steady state response, and resting EEG PSD for traditional frequency bands (eyes open/closed). Here, in an interim analysis of AMP SCZ EEG measures, we assess test-retest reliability and stability over sessions (baseline, month-2 follow-up) in CHR (n = 654) and community control (CON; n = 87) participants. Reliability was calculated as Generalizability (G)-coefficients, and changes over session were assessed with paired t-tests. G-coefficients were generally good to excellent in both groups (CHR: mean = 0.72, range = 0.49–0.85; CON: mean = 0.71, range = 0.44–0.89). Measure magnitudes significantly (p < 0.001) decreased over session (MMN, auditory and visual target P3b, visual novel P3a, 40-Hz ASSR) and/or over runs within sessions (MMN, auditory/visual novel P3a and target P3b), consistent with habituation effects. Despite these small systematic habituation effects, test-retest reliabilities of the AMP SCZ EEG-based measures are sufficiently strong to support their use in CHR studies as potential predictors of clinical outcomes, markers of illness progression, and/or target engagement or secondary outcome measures in controlled clinical trials. Watch Dr Daniel H. Mathalon discuss their work and this article: https://vimeo.com/1066564687 . |
| format | Article |
| id | doaj-art-649c531fab0844479bbe6afc8fa9e064 |
| institution | DOAJ |
| issn | 2754-6993 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Schizophrenia |
| spelling | doaj-art-649c531fab0844479bbe6afc8fa9e0642025-08-20T03:22:50ZengNature PortfolioSchizophrenia2754-69932025-06-0111111810.1038/s41537-025-00622-0The electroencephalography protocol for the Accelerating Medicines Partnership® Schizophrenia Program: Reliability and stability of measuresDaniel H. Mathalon0Spero Nicholas1Brian J. Roach2Tashrif Billah3Suzie Lavoie4Thomas Whitford5Holly K. Hamilton6Lauren Addamo7Andrey Anohkin8Tristan Bekinschtein9Aysenil Belger10Kate Buccilli11John Cahill12Ricardo E. Carrión13Stefano Damiani14Ilvana Dzafic15Bjørn H. Ebdrup16Igor Izyurov17Johanna Jarcho18Raoul Jenni19Anna Jo20Sarah Kerins21Clarice Lee22Elizabeth A. Martin23Rocio Mayol-Troncoso24Margaret A. Niznikiewicz25Muhammad Parvaz26Oliver Pogarell27Julio Prieto-Montalvo28Rachel Rabin29David R. Roalf30Jack Rogers31Dean F. Salisbury32Riaz Shaik33Stewart Shankman34Michael C. Stevens35Yi Nam Suen36Nicole C. Swann37Xiaochen Tang38Judy L. Thompson39Ivy Tso40Julian Wenzel41Juan Helen Zhou42Jean Addington43Luis Alameda44Celso Arango45Nicholas J. K. Breitborde46Matthew R. Broome47Kristin S. Cadenhead48Monica E. Calkins49Rolando I. Castillo-Passi50Eric Yu Hai Chen51Jimmy Choi52Philippe Conus53Cheryl M. Corcoran54Barbara A. Cornblatt55Covadonga M. Diaz-Caneja56Lauren M. Ellman57Paolo Fusar-Poli58Pablo A. Gaspar59Carla Gerber60Louise Birkedal Glenthøj61Leslie E. Horton62Christy Lai Ming Hui63Joseph Kambeitz64Lana Kambeitz-Ilankovic65Matcheri S. Keshavan66Minah Kim67Sung-Wan Kim68Nikolaos Koutsouleris69Jun Soo Kwon70Kerstin Langbein71Daniel Mamah72Vijay A. Mittal73Merete Nordentoft74Godfrey D. Pearlson75Jesus Perez76Diana O. Perkins77Albert R. Powers78Fred W. Sabb79Jason Schiffman80Jai L. Shah81Steven M. Silverstein82Stefan Smesny83William S. Stone84Gregory P. Strauss85Rachel Upthegrove86Swapna K. Verma87Jijun Wang88Daniel H. Wolf89Tianhong Zhang90Sylvain Bouix91Ofer Pasternak92Kang-Ik K. Cho93Michael J. Coleman94Dominic Dwyer95Angela Nunez96Zailyn Tamayo97Stephen J. Wood98Rene S. Kahn99John M. Kane100Patrick D. McGorry101Carrie E. Bearden102Barnaby Nelson103Scott W. Woods104Martha E. Shenton105Accelerating Medicines Partnership® Schizophrenia ProgramGregory A. Light106Department of Psychiatry and Behavioral Sciences and Weill Institute for Neurosciences, University of California San FranciscoMental Health Service, Veterans Affairs San Francisco Health Care SystemMental Health Service, Veterans Affairs San Francisco Health Care SystemDepartment of Psychiatry, Brigham and Women’s Hospital and Harvard Medical SchoolOrygenOrygenDepartment of Psychiatry and Behavioral Sciences and Weill Institute for Neurosciences, University of California San FranciscoOrygenWashington University School of MedicineConsciousness and Cognition Lab, Department of Psychology, University of CambridgeDepartment of Psychiatry, University of North Carolina at Chapel HillOrygenDepartment of Psychiatry, Yale University School of MedicineDepartment of Psychiatry, Donald and Barbara Zucker School of Medicine at Hofstra/NorthwellDepartment of Brain and Behavioral Sciences, University of PaviaOrygenCentre for Neuropsychiatric Schizophrenia Research, CNSR Mental Health CentreDepartment of Psychiatry and Psychotherapy, Jena University HospitalDepartment of Psychology & Neuroscience, Temple UniversityCenter for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital and University of Lausanne (CHUV-UNIL)Department of Psychiatry, Chonnam National University Medical SchoolEarly Psychosis Detection and Clinical Intervention (EPIC) lab, Department of Psychosis Studies, King’s CollegeOrygenDepartment of Psychological Science, University of CaliforniaDepartment of Psychiatry, IMHAY, University of ChileHarvard Medical SchoolDepartment of Psychiatry, Icahn School of Medicine at Mount SinaiDepartment of Psychiatry and Psychotherapy, Ludwig Maximilian University of MunichDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, Instituto de Salud Carlos III, School of Medicine, Universidad ComplutensePEPP-Montreal, Douglas Research CentreDepartment of Psychiatry, Perelman School of Medicine, University of PennsylvaniaInstitute for Mental Health, University of BirminghamDepartment of Psychiatry, University of Pittsburgh School of MedicineDepartment of Psychiatry, Icahn School of Medicine at Mount SinaiDepartment of Psychiatry and Behavioral Sciences, Northwestern UniversityDepartment of Psychiatry, Yale University School of MedicineSchool of Nursing, LKS Faculty of Medicine, University of Hong KongDepartment of Human Physiology, University of OregonShanghai Mental Health Center, Shanghai Jiaotong University School of MedicineDepartments of Psychiatry and Neuroscience, University of Rochester Medical CenterDepartment of Psychiatry and Behavioral Health, Ohio State University Wexner Medical CenterDepartment of Psychiatry, Faculty of Medicine and University Hospital Cologne, University of CologneCentre for Sleep and Cognition, Yong Loo Lin School of Medicine, National University of SingaporeDepartment of Psychiatry, Hotchkiss Brain Institute, University of CalgaryGeneral Psychiatry Service, Treatment and Early Intervention in Psychosis Program (TIPP–Lausanne), Lausanne University Hospital and University of LausanneDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, Instituto de Salud Carlos III, School of Medicine, Universidad ComplutenseDepartment of Psychiatry and Behavioral Health, Ohio State University Wexner Medical CenterInstitute for Mental Health, University of BirminghamDepartment of Psychiatry, University of CaliforniaDepartment of Psychiatry, Perelman School of Medicine, University of PennsylvaniaDepartment of Psychiatry, IMHAY, University of ChileDepartment of Psychiatry, School of Clinical Medicine, LKF Faculty of Medicine, University of Hong KongOlin Neuropsychiatry Research Center, Hartford HealthCare Behavioral Health NetworkGeneral Psychiatry Service, Treatment and Early Intervention in Psychosis Program (TIPP–Lausanne), Lausanne University Hospital and University of LausanneDepartment of Psychiatry, Icahn School of Medicine at Mount SinaiDepartment of Psychiatry, Donald and Barbara Zucker School of Medicine at Hofstra/NorthwellDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, Instituto de Salud Carlos III, School of Medicine, Universidad ComplutenseDepartment of Psychology & Neuroscience, Temple UniversityDepartment of Brain and Behavioral Sciences, University of PaviaDepartment of Psychiatry, IMHAY, University of ChilePrevention Science Institute, University of OregonCopenhagen Research Centre for Mental Health, Mental Health Copenhagen, University of CopenhagenDepartment of Psychiatry, University of Pittsburgh School of MedicineDepartment of Psychiatry, School of Clinical Medicine, LKF Faculty of Medicine, University of Hong KongDepartment of Psychiatry, Faculty of Medicine and University Hospital Cologne, University of CologneDepartment of Psychiatry and Psychotherapy, Ludwig Maximilian University of MunichDepartment of Psychiatry, Beth Israel Deaconess Medical Center and Harvard Medical SchoolDepartment of Neuropsychiatry, Seoul National University HospitalDepartment of Psychiatry, Chonnam National University Medical SchoolDepartment of Psychiatry and Psychotherapy, Ludwig Maximilian University of MunichDepartment of Psychiatry, Hanyang University HospitalDepartment of Psychiatry and Psychotherapy, Jena University HospitalDepartment of Psychiatry, Washington University Medical SchoolDepartment of Psychology, Northwestern UniversityDepartment of Clinical Medicine, University of CopenhagenDepartment of Psychiatry, Yale University School of MedicineCAMEO, Early Intervention in Psychosis Service, Cambridgeshire and Peterborough NHS Foundation TrustDepartment of Psychiatry, University of North Carolina at Chapel HillDepartment of Psychiatry, Yale University School of MedicinePrevention Science Institute, University of OregonDepartment of Psychological Science, University of CaliforniaDepartment of Psychiatry, McGill UniversityDepartments of Psychiatry and Neuroscience, University of Rochester Medical CenterDepartment of Psychiatry and Psychotherapy, Jena University HospitalDepartment of Psychiatry, Beth Israel Deaconess Medical Center and Harvard Medical SchoolDepartment of Psychology, University of GeorgiaInstitute for Mental Health, University of BirminghamInstitute of Mental HealthShanghai Mental Health Center, Shanghai Jiaotong University School of MedicineDepartment of Psychiatry, Perelman School of Medicine, University of PennsylvaniaShanghai Mental Health Center, Shanghai Jiaotong University School of MedicineDepartment of Software Engineering and Information Technology, École de technologie supérieureDepartment of Psychiatry, Brigham and Women’s Hospital and Harvard Medical SchoolDepartment of Psychiatry, Brigham and Women’s Hospital and Harvard Medical SchoolDepartment of Psychiatry, Brigham and Women’s Hospital and Harvard Medical SchoolOrygenDepartment of Psychiatry, Yale University School of MedicineDepartment of Psychiatry, Yale University School of MedicineOrygenDepartment of Psychiatry, Icahn School of Medicine at Mount SinaiDepartment of Psychiatry, Donald and Barbara Zucker School of Medicine at Hofstra/NorthwellOrygenDepartment of Psychological Science, University of CaliforniaOrygenDepartment of Psychiatry, Yale University School of MedicineDepartment of Psychiatry, Brigham and Women’s Hospital and Harvard Medical SchoolDepartment of Psychiatry, University of CaliforniaAbstract Individuals at clinical high risk for psychosis (CHR) have variable clinical outcomes and low conversion rates, limiting development of novel and personalized treatments. Moreover, given risks of antipsychotic drugs, safer effective medications for CHR individuals are needed. The Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ) Program was launched to address this need. Based on past CHR and schizophrenia studies, AMP SCZ assessed electroencephalography (EEG)-based event-related potential (ERP), event-related oscillation (ERO), and resting EEG power spectral density (PSD) measures, including mismatch negativity (MMN), auditory and visual P300 to target (P3b) and novel (P3a) stimuli, 40-Hz auditory steady state response, and resting EEG PSD for traditional frequency bands (eyes open/closed). Here, in an interim analysis of AMP SCZ EEG measures, we assess test-retest reliability and stability over sessions (baseline, month-2 follow-up) in CHR (n = 654) and community control (CON; n = 87) participants. Reliability was calculated as Generalizability (G)-coefficients, and changes over session were assessed with paired t-tests. G-coefficients were generally good to excellent in both groups (CHR: mean = 0.72, range = 0.49–0.85; CON: mean = 0.71, range = 0.44–0.89). Measure magnitudes significantly (p < 0.001) decreased over session (MMN, auditory and visual target P3b, visual novel P3a, 40-Hz ASSR) and/or over runs within sessions (MMN, auditory/visual novel P3a and target P3b), consistent with habituation effects. Despite these small systematic habituation effects, test-retest reliabilities of the AMP SCZ EEG-based measures are sufficiently strong to support their use in CHR studies as potential predictors of clinical outcomes, markers of illness progression, and/or target engagement or secondary outcome measures in controlled clinical trials. Watch Dr Daniel H. Mathalon discuss their work and this article: https://vimeo.com/1066564687 .https://doi.org/10.1038/s41537-025-00622-0 |
| spellingShingle | Daniel H. Mathalon Spero Nicholas Brian J. Roach Tashrif Billah Suzie Lavoie Thomas Whitford Holly K. Hamilton Lauren Addamo Andrey Anohkin Tristan Bekinschtein Aysenil Belger Kate Buccilli John Cahill Ricardo E. Carrión Stefano Damiani Ilvana Dzafic Bjørn H. Ebdrup Igor Izyurov Johanna Jarcho Raoul Jenni Anna Jo Sarah Kerins Clarice Lee Elizabeth A. Martin Rocio Mayol-Troncoso Margaret A. Niznikiewicz Muhammad Parvaz Oliver Pogarell Julio Prieto-Montalvo Rachel Rabin David R. Roalf Jack Rogers Dean F. Salisbury Riaz Shaik Stewart Shankman Michael C. Stevens Yi Nam Suen Nicole C. Swann Xiaochen Tang Judy L. Thompson Ivy Tso Julian Wenzel Juan Helen Zhou Jean Addington Luis Alameda Celso Arango Nicholas J. K. Breitborde Matthew R. Broome Kristin S. Cadenhead Monica E. Calkins Rolando I. Castillo-Passi Eric Yu Hai Chen Jimmy Choi Philippe Conus Cheryl M. Corcoran Barbara A. Cornblatt Covadonga M. Diaz-Caneja Lauren M. Ellman Paolo Fusar-Poli Pablo A. Gaspar Carla Gerber Louise Birkedal Glenthøj Leslie E. Horton Christy Lai Ming Hui Joseph Kambeitz Lana Kambeitz-Ilankovic Matcheri S. Keshavan Minah Kim Sung-Wan Kim Nikolaos Koutsouleris Jun Soo Kwon Kerstin Langbein Daniel Mamah Vijay A. Mittal Merete Nordentoft Godfrey D. Pearlson Jesus Perez Diana O. Perkins Albert R. Powers Fred W. Sabb Jason Schiffman Jai L. Shah Steven M. Silverstein Stefan Smesny William S. Stone Gregory P. Strauss Rachel Upthegrove Swapna K. Verma Jijun Wang Daniel H. Wolf Tianhong Zhang Sylvain Bouix Ofer Pasternak Kang-Ik K. Cho Michael J. Coleman Dominic Dwyer Angela Nunez Zailyn Tamayo Stephen J. Wood Rene S. Kahn John M. Kane Patrick D. McGorry Carrie E. Bearden Barnaby Nelson Scott W. Woods Martha E. Shenton Accelerating Medicines Partnership® Schizophrenia Program Gregory A. Light The electroencephalography protocol for the Accelerating Medicines Partnership® Schizophrenia Program: Reliability and stability of measures Schizophrenia |
| title | The electroencephalography protocol for the Accelerating Medicines Partnership® Schizophrenia Program: Reliability and stability of measures |
| title_full | The electroencephalography protocol for the Accelerating Medicines Partnership® Schizophrenia Program: Reliability and stability of measures |
| title_fullStr | The electroencephalography protocol for the Accelerating Medicines Partnership® Schizophrenia Program: Reliability and stability of measures |
| title_full_unstemmed | The electroencephalography protocol for the Accelerating Medicines Partnership® Schizophrenia Program: Reliability and stability of measures |
| title_short | The electroencephalography protocol for the Accelerating Medicines Partnership® Schizophrenia Program: Reliability and stability of measures |
| title_sort | electroencephalography protocol for the accelerating medicines partnership r schizophrenia program reliability and stability of measures |
| url | https://doi.org/10.1038/s41537-025-00622-0 |
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electroencephalographyprotocolfortheacceleratingmedicinespartnershipschizophreniaprogramreliabilityandstabilityofmeasures AT reneskahn electroencephalographyprotocolfortheacceleratingmedicinespartnershipschizophreniaprogramreliabilityandstabilityofmeasures AT johnmkane electroencephalographyprotocolfortheacceleratingmedicinespartnershipschizophreniaprogramreliabilityandstabilityofmeasures AT patrickdmcgorry electroencephalographyprotocolfortheacceleratingmedicinespartnershipschizophreniaprogramreliabilityandstabilityofmeasures AT carrieebearden electroencephalographyprotocolfortheacceleratingmedicinespartnershipschizophreniaprogramreliabilityandstabilityofmeasures AT barnabynelson electroencephalographyprotocolfortheacceleratingmedicinespartnershipschizophreniaprogramreliabilityandstabilityofmeasures AT scottwwoods electroencephalographyprotocolfortheacceleratingmedicinespartnershipschizophreniaprogramreliabilityandstabilityofmeasures AT marthaeshenton electroencephalographyprotocolfortheacceleratingmedicinespartnershipschizophreniaprogramreliabilityandstabilityofmeasures AT acceleratingmedicinespartnershipschizophreniaprogram electroencephalographyprotocolfortheacceleratingmedicinespartnershipschizophreniaprogramreliabilityandstabilityofmeasures AT gregoryalight electroencephalographyprotocolfortheacceleratingmedicinespartnershipschizophreniaprogramreliabilityandstabilityofmeasures |