Phlegmasia cerulea dolens as a complication of radiation therapy in endometrial cancer: a case report
This study reports the case of a 61-year-old female patient with recurrent endometrial cancer who developed phlegmasia cerulea dolens and compartment syndrome of the right lower extremity 1 day after receiving high-dose radiation therapy. In addition, the patient had a right main pulmonary artery em...
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Elsevier
2025-02-01
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| Series: | AJOG Global Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666577825000048 |
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| author | Milan Ho, BS Arash Fereydooni, MD, MS, MHS Graeme McFarland, MD Babak Litkouhi, MD Amer Karam, MD Edmund J. Harris, Jr, MD Elizabeth L. George, MD, MS |
| author_facet | Milan Ho, BS Arash Fereydooni, MD, MS, MHS Graeme McFarland, MD Babak Litkouhi, MD Amer Karam, MD Edmund J. Harris, Jr, MD Elizabeth L. George, MD, MS |
| author_sort | Milan Ho, BS |
| collection | DOAJ |
| description | This study reports the case of a 61-year-old female patient with recurrent endometrial cancer who developed phlegmasia cerulea dolens and compartment syndrome of the right lower extremity 1 day after receiving high-dose radiation therapy. In addition, the patient had a right main pulmonary artery embolus. The patient underwent inferior vena cava filter placement, open common femoral vein thrombectomy, 4-compartment fasciotomy, and vacuum-assisted superficial groin wound closure. The patient was discharged on postoperative day 6 on rivaroxaban. Imaging at 6 months and 1 year postoperatively demonstrated a wide patency of the deep venous system in the right lower extremity, and anticoagulation was discontinued. The patient was followed up for surveillance in a gynecologic oncology clinic with no evidence of disease for 2 years, after which the patient was transferred to an outside facility. In conclusion, phlegmasia cerulea dolens can occur in the setting of immobility because of high-dose radiation therapy and in the absence of deep venous thrombosis prophylaxis. Rapid identification of phlegmasia cerulea dolens on physical examination and early vascular surgical intervention can result in favorable outcomes. |
| format | Article |
| id | doaj-art-64908b8cbe7f47c3b173f2dfcd197feb |
| institution | DOAJ |
| issn | 2666-5778 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | AJOG Global Reports |
| spelling | doaj-art-64908b8cbe7f47c3b173f2dfcd197feb2025-08-20T03:17:47ZengElsevierAJOG Global Reports2666-57782025-02-015110044310.1016/j.xagr.2025.100443Phlegmasia cerulea dolens as a complication of radiation therapy in endometrial cancer: a case reportMilan Ho, BS0Arash Fereydooni, MD, MS, MHS1Graeme McFarland, MD2Babak Litkouhi, MD3Amer Karam, MD4Edmund J. Harris, Jr, MD5Elizabeth L. George, MD, MS6University of Texas Southwestern Medical Center, Dallas, TX (Ho); Corresponding author: Milan Ho, BS.Division of Vascular and Endovascular Surgery, Department of Surgery, Stanford University Medical Center, Stanford, CA (Fereydooni, McFarland, Harris, and George)Division of Vascular and Endovascular Surgery, Department of Surgery, Stanford University Medical Center, Stanford, CA (Fereydooni, McFarland, Harris, and George)Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Stanford University, Stanford, CA (Litkouhi and Karam).Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Stanford University, Stanford, CA (Litkouhi and Karam).Division of Vascular and Endovascular Surgery, Department of Surgery, Stanford University Medical Center, Stanford, CA (Fereydooni, McFarland, Harris, and George)Division of Vascular and Endovascular Surgery, Department of Surgery, Stanford University Medical Center, Stanford, CA (Fereydooni, McFarland, Harris, and George)This study reports the case of a 61-year-old female patient with recurrent endometrial cancer who developed phlegmasia cerulea dolens and compartment syndrome of the right lower extremity 1 day after receiving high-dose radiation therapy. In addition, the patient had a right main pulmonary artery embolus. The patient underwent inferior vena cava filter placement, open common femoral vein thrombectomy, 4-compartment fasciotomy, and vacuum-assisted superficial groin wound closure. The patient was discharged on postoperative day 6 on rivaroxaban. Imaging at 6 months and 1 year postoperatively demonstrated a wide patency of the deep venous system in the right lower extremity, and anticoagulation was discontinued. The patient was followed up for surveillance in a gynecologic oncology clinic with no evidence of disease for 2 years, after which the patient was transferred to an outside facility. In conclusion, phlegmasia cerulea dolens can occur in the setting of immobility because of high-dose radiation therapy and in the absence of deep venous thrombosis prophylaxis. Rapid identification of phlegmasia cerulea dolens on physical examination and early vascular surgical intervention can result in favorable outcomes.http://www.sciencedirect.com/science/article/pii/S2666577825000048case reportendometrial cancerphlegmasia cerulea dolensradiation therapy |
| spellingShingle | Milan Ho, BS Arash Fereydooni, MD, MS, MHS Graeme McFarland, MD Babak Litkouhi, MD Amer Karam, MD Edmund J. Harris, Jr, MD Elizabeth L. George, MD, MS Phlegmasia cerulea dolens as a complication of radiation therapy in endometrial cancer: a case report AJOG Global Reports case report endometrial cancer phlegmasia cerulea dolens radiation therapy |
| title | Phlegmasia cerulea dolens as a complication of radiation therapy in endometrial cancer: a case report |
| title_full | Phlegmasia cerulea dolens as a complication of radiation therapy in endometrial cancer: a case report |
| title_fullStr | Phlegmasia cerulea dolens as a complication of radiation therapy in endometrial cancer: a case report |
| title_full_unstemmed | Phlegmasia cerulea dolens as a complication of radiation therapy in endometrial cancer: a case report |
| title_short | Phlegmasia cerulea dolens as a complication of radiation therapy in endometrial cancer: a case report |
| title_sort | phlegmasia cerulea dolens as a complication of radiation therapy in endometrial cancer a case report |
| topic | case report endometrial cancer phlegmasia cerulea dolens radiation therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2666577825000048 |
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