Gender-based factors associated with hepatitis C testing in people who inject drugs: results from the French COSINUS cohort
Objective We identified factors associated with hepatitis C virus (HCV) testing in the previous 6 months in people who inject drugs (PWID) according to gender.Design COSINUS (Cohorte pour l’évaluation des facteurs Structurels et Individuels de l’USage de drogues) is a multisite longitudinal cohort s...
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BMJ Publishing Group
2025-03-01
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| Online Access: | https://bmjopen.bmj.com/content/15/3/e091707.full |
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| author | Maria Patrizia Carrieri Marc Auriacombe Perrine Roux Laélia Briand Madrid Sébastien Kirchherr Charlotte Kervran Carole Chauvin Marie Gutowski Cécile Denis Laurence Lalanne Marie Jauffret-Roustide Gilles Bertoia Laélia Briand Madrid Isabelle Célérier Jean-marie Danion Natascia Grelli Naomi Hamelin Mireille Le Breton Antoine Vilotitch Gwenaëlle Maradan Cyril Berenger Sarah Moriceau Ilhame Anwar Aissatou Faye Cécile Donadille Manon Chevalier Sébastien de Dinechin |
| author_facet | Maria Patrizia Carrieri Marc Auriacombe Perrine Roux Laélia Briand Madrid Sébastien Kirchherr Charlotte Kervran Carole Chauvin Marie Gutowski Cécile Denis Laurence Lalanne Marie Jauffret-Roustide Gilles Bertoia Laélia Briand Madrid Isabelle Célérier Jean-marie Danion Natascia Grelli Naomi Hamelin Mireille Le Breton Antoine Vilotitch Gwenaëlle Maradan Cyril Berenger Sarah Moriceau Ilhame Anwar Aissatou Faye Cécile Donadille Manon Chevalier Sébastien de Dinechin |
| collection | DOAJ |
| description | Objective We identified factors associated with hepatitis C virus (HCV) testing in the previous 6 months in people who inject drugs (PWID) according to gender.Design COSINUS (Cohorte pour l’évaluation des facteurs Structurels et Individuels de l’USage de drogues) is a multisite longitudinal cohort study conducted between June 2016 and May 2019.Setting Harm reduction facilities in two French cities (Marseille and Bordeaux).Participants Eligibility criteria were as follows: 18 years of age or older, French speaking, regular use of illegal drugs or of prescribed medication, having injected at least once in the previous month and being able to provide informed consent to participate. We selected data for 298 participants (624 observations).Primary outcome Self-reporting HCV testing in the previous 6 months. Gender was defined as self-identifying as a woman, man or transgender person.Results Seventy-nine per cent (n=235) of the sample were men, and 63% (n=189) reported HCV testing in the previous 6 months. Our results suggest that men recently incarcerated (OR (95% CI): 3.26 (1.31, 8.12), p=0.011), those regularly attending harm reduction facilities (OR (95% CI): 2.49 (1.47, 4.22), p=0.001), and those with lifetime attempted suicide (OR (95% CI): 2.07 (1.08, 3.95), p=0.028) were more likely to have been tested for HCV in the previous 6 months, whereas older men were less likely (OR (95% CI): 0.46 (0.24, 0.89), p=0.022). Women who had slept in the street (OR (95% CI): 3.95 (1.12, 13.89), p=0.032) were more likely to have been tested for HCV in the previous 6 months, whereas those employed (OR (95% CI): 0.31 (0.12, 0.83), p=0.019) and those with lifetime attempted suicide (OR (95% CI): 0.39 (0.16, 0.97), p=0.044) were less likely.Conclusion Our results highlight the importance of improving current harm reduction facilities for PWID by adapting them to women’s needs and paying special attention to women’s mental health. Furthermore, in the context of primary care, improving provider training and reducing injection-related stigma may improve HCV testing uptake in older men and employed women. |
| format | Article |
| id | doaj-art-648e5e603ce340e4a93afb81f959a6dd |
| institution | DOAJ |
| issn | 2044-6055 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-648e5e603ce340e4a93afb81f959a6dd2025-08-20T02:54:04ZengBMJ Publishing GroupBMJ Open2044-60552025-03-0115310.1136/bmjopen-2024-091707Gender-based factors associated with hepatitis C testing in people who inject drugs: results from the French COSINUS cohort Maria Patrizia CarrieriMarc Auriacombe0Perrine Roux1Laélia Briand Madrid2Sébastien KirchherrCharlotte KervranCarole ChauvinMarie GutowskiCécile DenisLaurence Lalanne3Marie Jauffret-Roustide4Gilles BertoiaLaélia Briand MadridIsabelle CélérierJean-marie DanionNatascia GrelliNaomi HamelinMireille Le BretonAntoine VilotitchGwenaëlle MaradanCyril BerengerSarah MoriceauIlhame Anwar5Aissatou Faye6Cécile Donadille7Manon ChevalierSébastien de DinechinBordeaux University, SANPSY, CNRS UMR 6033, Bordeaux, FranceAix Marseille Univ, Inserm, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l’Information Médicale, ISSPAM, Marseille, FranceAix Marseille Univ, Inserm, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l’Information Médicale, ISSPAM, Marseille, FranceINSERM 1114, Département de Psychiatrie et Addictologie, Hôpital Universitaire de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Strasbourg, FranceCentre d’Étude des Mouvements Sociaux, Inserm U1276/CNRS UMR 8044/EHESS, Paris, FranceAix Marseille Univ, Inserm, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l’Information Médicale, ISSPAM, Marseille, FranceAix Marseille Univ, Inserm, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l’Information Médicale, ISSPAM, Marseille, FranceAix Marseille Univ, Inserm, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l’Information Médicale, ISSPAM, Marseille, FranceObjective We identified factors associated with hepatitis C virus (HCV) testing in the previous 6 months in people who inject drugs (PWID) according to gender.Design COSINUS (Cohorte pour l’évaluation des facteurs Structurels et Individuels de l’USage de drogues) is a multisite longitudinal cohort study conducted between June 2016 and May 2019.Setting Harm reduction facilities in two French cities (Marseille and Bordeaux).Participants Eligibility criteria were as follows: 18 years of age or older, French speaking, regular use of illegal drugs or of prescribed medication, having injected at least once in the previous month and being able to provide informed consent to participate. We selected data for 298 participants (624 observations).Primary outcome Self-reporting HCV testing in the previous 6 months. Gender was defined as self-identifying as a woman, man or transgender person.Results Seventy-nine per cent (n=235) of the sample were men, and 63% (n=189) reported HCV testing in the previous 6 months. Our results suggest that men recently incarcerated (OR (95% CI): 3.26 (1.31, 8.12), p=0.011), those regularly attending harm reduction facilities (OR (95% CI): 2.49 (1.47, 4.22), p=0.001), and those with lifetime attempted suicide (OR (95% CI): 2.07 (1.08, 3.95), p=0.028) were more likely to have been tested for HCV in the previous 6 months, whereas older men were less likely (OR (95% CI): 0.46 (0.24, 0.89), p=0.022). Women who had slept in the street (OR (95% CI): 3.95 (1.12, 13.89), p=0.032) were more likely to have been tested for HCV in the previous 6 months, whereas those employed (OR (95% CI): 0.31 (0.12, 0.83), p=0.019) and those with lifetime attempted suicide (OR (95% CI): 0.39 (0.16, 0.97), p=0.044) were less likely.Conclusion Our results highlight the importance of improving current harm reduction facilities for PWID by adapting them to women’s needs and paying special attention to women’s mental health. Furthermore, in the context of primary care, improving provider training and reducing injection-related stigma may improve HCV testing uptake in older men and employed women.https://bmjopen.bmj.com/content/15/3/e091707.full |
| spellingShingle | Maria Patrizia Carrieri Marc Auriacombe Perrine Roux Laélia Briand Madrid Sébastien Kirchherr Charlotte Kervran Carole Chauvin Marie Gutowski Cécile Denis Laurence Lalanne Marie Jauffret-Roustide Gilles Bertoia Laélia Briand Madrid Isabelle Célérier Jean-marie Danion Natascia Grelli Naomi Hamelin Mireille Le Breton Antoine Vilotitch Gwenaëlle Maradan Cyril Berenger Sarah Moriceau Ilhame Anwar Aissatou Faye Cécile Donadille Manon Chevalier Sébastien de Dinechin Gender-based factors associated with hepatitis C testing in people who inject drugs: results from the French COSINUS cohort BMJ Open |
| title | Gender-based factors associated with hepatitis C testing in people who inject drugs: results from the French COSINUS cohort |
| title_full | Gender-based factors associated with hepatitis C testing in people who inject drugs: results from the French COSINUS cohort |
| title_fullStr | Gender-based factors associated with hepatitis C testing in people who inject drugs: results from the French COSINUS cohort |
| title_full_unstemmed | Gender-based factors associated with hepatitis C testing in people who inject drugs: results from the French COSINUS cohort |
| title_short | Gender-based factors associated with hepatitis C testing in people who inject drugs: results from the French COSINUS cohort |
| title_sort | gender based factors associated with hepatitis c testing in people who inject drugs results from the french cosinus cohort |
| url | https://bmjopen.bmj.com/content/15/3/e091707.full |
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