Transdermal delivery of tolterodine tartrate for overactive bladder treatment: In vitro and in vivo evaluation
The purpose of the study was to develop a transdermal tolterodine tartrate (TT) patch and to analyse its efficacy for overactive bladder (OAB) treatment. Patches were prepared using various polymers and plasticizers via the solvent casting method. The patches were characterized for tensile strength,...
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| Format: | Article |
| Language: | English |
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Sciendo
2017-09-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.1515/acph-2017-0027 |
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| author | Rajabalaya Rajan Mun Chung Yee Chellian Jestin Chakravarthi Srikumar David Sheba R. |
| author_facet | Rajabalaya Rajan Mun Chung Yee Chellian Jestin Chakravarthi Srikumar David Sheba R. |
| author_sort | Rajabalaya Rajan |
| collection | DOAJ |
| description | The purpose of the study was to develop a transdermal tolterodine tartrate (TT) patch and to analyse its efficacy for overactive bladder (OAB) treatment. Patches were prepared using various polymers and plasticizers via the solvent casting method. The patches were characterized for tensile strength, thickness, moisture content, modulus of elasticity and water absorption capacity. Differential scanning calorimetry and Fourier transform infrared analyses were also performed. To determine patch effectiveness, in vitro release, permeation and animal studies were performed. The patches showed satisfactory percentage of release, up to 89.9 %, and their mechanical properties included thickness (0.10–0.15 mm), tensile strength (4.62–9.98 MPa) and modulus of elasticity (20–29 MPa). There were no significant interactions between TT and other excipients. Animal studies indicated that the TT patch reduced the incidence of side effects; however, studies of longer duration are required to determine the effectiveness in treating OAB. |
| format | Article |
| id | doaj-art-64895be56c5d4f3592df1aa37b7c3864 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2017-09-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-64895be56c5d4f3592df1aa37b7c38642025-02-02T11:59:26ZengSciendoActa Pharmaceutica1846-95582017-09-0167332533910.1515/acph-2017-0027acph-2017-0027Transdermal delivery of tolterodine tartrate for overactive bladder treatment: In vitro and in vivo evaluationRajabalaya Rajan0Mun Chung Yee1Chellian Jestin2Chakravarthi Srikumar3David Sheba R.4PAPRSB Institute of Health Sciences, Universit Brunei Darussalam, Bandar Seri Begawan BE1410, Brunei DarussalamSchool of Pharmacy, International Medical University, Bukit Jalil 57000, Kuala Lumpur, MalaysiaSchool of Pharmacy, International Medical University, Bukit Jalil 57000, Kuala Lumpur, MalaysiaSchool of Pharmacy, International Medical University, Bukit Jalil 57000, Kuala Lumpur, MalaysiaPAPRSB Institute of Health Sciences, Universit Brunei Darussalam, Bandar Seri Begawan BE1410, Brunei DarussalamThe purpose of the study was to develop a transdermal tolterodine tartrate (TT) patch and to analyse its efficacy for overactive bladder (OAB) treatment. Patches were prepared using various polymers and plasticizers via the solvent casting method. The patches were characterized for tensile strength, thickness, moisture content, modulus of elasticity and water absorption capacity. Differential scanning calorimetry and Fourier transform infrared analyses were also performed. To determine patch effectiveness, in vitro release, permeation and animal studies were performed. The patches showed satisfactory percentage of release, up to 89.9 %, and their mechanical properties included thickness (0.10–0.15 mm), tensile strength (4.62–9.98 MPa) and modulus of elasticity (20–29 MPa). There were no significant interactions between TT and other excipients. Animal studies indicated that the TT patch reduced the incidence of side effects; however, studies of longer duration are required to determine the effectiveness in treating OAB.https://doi.org/10.1515/acph-2017-0027tolterodine tartratetransdermaloveractive bladdermatrix patchespermeation |
| spellingShingle | Rajabalaya Rajan Mun Chung Yee Chellian Jestin Chakravarthi Srikumar David Sheba R. Transdermal delivery of tolterodine tartrate for overactive bladder treatment: In vitro and in vivo evaluation Acta Pharmaceutica tolterodine tartrate transdermal overactive bladder matrix patches permeation |
| title | Transdermal delivery of tolterodine tartrate for overactive bladder treatment: In vitro and in vivo evaluation |
| title_full | Transdermal delivery of tolterodine tartrate for overactive bladder treatment: In vitro and in vivo evaluation |
| title_fullStr | Transdermal delivery of tolterodine tartrate for overactive bladder treatment: In vitro and in vivo evaluation |
| title_full_unstemmed | Transdermal delivery of tolterodine tartrate for overactive bladder treatment: In vitro and in vivo evaluation |
| title_short | Transdermal delivery of tolterodine tartrate for overactive bladder treatment: In vitro and in vivo evaluation |
| title_sort | transdermal delivery of tolterodine tartrate for overactive bladder treatment in vitro and in vivo evaluation |
| topic | tolterodine tartrate transdermal overactive bladder matrix patches permeation |
| url | https://doi.org/10.1515/acph-2017-0027 |
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