Morphological and Functional Characteristics of Animal Models of Myocardial Fibrosis Induced by Pressure Overload
Myocardial fibrosis is characterized by excessive deposition of myocardial interstitial collagen, abnormal distribution, and excessive proliferation of fibroblasts. According to the researches in recent years, myocardial fibrosis, as the pathological basis of various cardiovascular diseases, has bee...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.1155/2020/3014693 |
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| author | Yuejia Ding Yuan Wang Qiujin Jia Xiaoling Wang Yanmin Lu Ao Zhang Shichao Lv Junping Zhang |
| author_facet | Yuejia Ding Yuan Wang Qiujin Jia Xiaoling Wang Yanmin Lu Ao Zhang Shichao Lv Junping Zhang |
| author_sort | Yuejia Ding |
| collection | DOAJ |
| description | Myocardial fibrosis is characterized by excessive deposition of myocardial interstitial collagen, abnormal distribution, and excessive proliferation of fibroblasts. According to the researches in recent years, myocardial fibrosis, as the pathological basis of various cardiovascular diseases, has been proven to be a core determinant in ventricular remodeling. Pressure load is one of the causes of myocardial fibrosis. In experimental models of pressure-overload-induced myocardial fibrosis, significant increase in left ventricular parameters such as interventricular septal thickness and left ventricular posterior wall thickness and the decrease of ejection fraction are some of the manifestations of cardiac damage. These morphological and functional changes have a serious impact on the maintenance of physiological functions. Therefore, establishing a suitable myocardial fibrosis model is the basis of its pathogenesis research. This paper will discuss the methods of establishing myocardial fibrosis model and compare the advantages and disadvantages of the models in order to provide a strong basis for establishing a myocardial fibrosis model. |
| format | Article |
| id | doaj-art-647f5dbfd6f6467e8b1cd97c5dbb8ef4 |
| institution | Kabale University |
| issn | 2090-0384 2090-0392 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-647f5dbfd6f6467e8b1cd97c5dbb8ef42025-08-20T03:34:25ZengWileyInternational Journal of Hypertension2090-03842090-03922020-01-01202010.1155/2020/30146933014693Morphological and Functional Characteristics of Animal Models of Myocardial Fibrosis Induced by Pressure OverloadYuejia Ding0Yuan Wang1Qiujin Jia2Xiaoling Wang3Yanmin Lu4Ao Zhang5Shichao Lv6Junping Zhang7First Teaching Hospital, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, ChinaFirst Teaching Hospital, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, ChinaFirst Teaching Hospital, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, ChinaQian’an Hospital, Traditional Chinese Medicine, Qian’an 064400, ChinaTianjin Nankai Hospital, Tianjin 300381, ChinaCollege of Global Public Health, New York University, 726 Broadway, New York, NY 10003, USAFirst Teaching Hospital, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, ChinaFirst Teaching Hospital, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, ChinaMyocardial fibrosis is characterized by excessive deposition of myocardial interstitial collagen, abnormal distribution, and excessive proliferation of fibroblasts. According to the researches in recent years, myocardial fibrosis, as the pathological basis of various cardiovascular diseases, has been proven to be a core determinant in ventricular remodeling. Pressure load is one of the causes of myocardial fibrosis. In experimental models of pressure-overload-induced myocardial fibrosis, significant increase in left ventricular parameters such as interventricular septal thickness and left ventricular posterior wall thickness and the decrease of ejection fraction are some of the manifestations of cardiac damage. These morphological and functional changes have a serious impact on the maintenance of physiological functions. Therefore, establishing a suitable myocardial fibrosis model is the basis of its pathogenesis research. This paper will discuss the methods of establishing myocardial fibrosis model and compare the advantages and disadvantages of the models in order to provide a strong basis for establishing a myocardial fibrosis model.http://dx.doi.org/10.1155/2020/3014693 |
| spellingShingle | Yuejia Ding Yuan Wang Qiujin Jia Xiaoling Wang Yanmin Lu Ao Zhang Shichao Lv Junping Zhang Morphological and Functional Characteristics of Animal Models of Myocardial Fibrosis Induced by Pressure Overload International Journal of Hypertension |
| title | Morphological and Functional Characteristics of Animal Models of Myocardial Fibrosis Induced by Pressure Overload |
| title_full | Morphological and Functional Characteristics of Animal Models of Myocardial Fibrosis Induced by Pressure Overload |
| title_fullStr | Morphological and Functional Characteristics of Animal Models of Myocardial Fibrosis Induced by Pressure Overload |
| title_full_unstemmed | Morphological and Functional Characteristics of Animal Models of Myocardial Fibrosis Induced by Pressure Overload |
| title_short | Morphological and Functional Characteristics of Animal Models of Myocardial Fibrosis Induced by Pressure Overload |
| title_sort | morphological and functional characteristics of animal models of myocardial fibrosis induced by pressure overload |
| url | http://dx.doi.org/10.1155/2020/3014693 |
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