Integrative single-cell and spatial transcriptomics analysis reveals MDK-NCL pathway’s role in shaping the immunosuppressive environment of lung adenocarcinoma

Integrative single-cell and spatial transcriptomics analysis reveals MDK-NCL pathway’s role in shaping the immunosuppressive environment of lung adenocarcinoma

ObjectivesThe tumor microenvironment (TME) plays a critical role in the progression of lung adenocarcinoma (LUAD). This study aims to investigate the cellular composition of the TME in LUAD and assess the role of the MDK-NCL signaling pathway.MethodsWe employed a multi-omics strategy to investigate...

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Bibliographic Details
Main Authors: Yu Fu, Song Li, Yikang Zhao, Xiran Zhang, Xiaolu Mao, Ran Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
lung adenocarcinoma
tumor microenvironment
MDK-NCL
single-cell transcriptomics
spatial transcriptomics
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1546382/full
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