The new views on the state of the gut microbiota in obesity and diabetes mellitus type 2
Obesity is a worldwide problem of the last century, the prevalence of which has reached pandemic proportions in developed countries. Over the past few years, a considerable amount of data has been gathered, reporting a direct link between changes in gut microbiota and the development of obesity, as...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Endocrinology Research Centre
2019-08-01
|
| Series: | Сахарный диабет |
| Subjects: | |
| Online Access: | https://www.dia-endojournals.ru/jour/article/view/10194 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850254494084890624 |
|---|---|
| author | Elena V. Pokrovskaya Minara S. Shamkhalova Marina V. Shestakova |
| author_facet | Elena V. Pokrovskaya Minara S. Shamkhalova Marina V. Shestakova |
| author_sort | Elena V. Pokrovskaya |
| collection | DOAJ |
| description | Obesity is a worldwide problem of the last century, the prevalence of which has reached pandemic proportions in developed countries. Over the past few years, a considerable amount of data has been gathered, reporting a direct link between changes in gut microbiota and the development of obesity, as well as related diseases, primarily, diabetes mellitus type 2. The elaboration of optimal methods of prevention and treatment regimens of these diseases needs to structure the existing knowledge about the mechanisms of development of metabolic disorders, the role of intestinal microbiota in the latter and possible therapeutic “targets”. This review examines the role of microorganisms in the human body, with the main focus on the developmental origins of metabolic disorders using animal models and accumulated experience of research on their effects on the human body, and also discusses possible treatment options, including bariatric surgery, fecal microbiota transplantation, the use of pre- and probiotics and certain particular groups of glucose-lowering drugs. |
| format | Article |
| id | doaj-art-6465b11b6f634a90a81c1c22cd7fb1cc |
| institution | OA Journals |
| issn | 2072-0351 2072-0378 |
| language | English |
| publishDate | 2019-08-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj-art-6465b11b6f634a90a81c1c22cd7fb1cc2025-08-20T01:57:08ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782019-08-0122325326210.14341/DM101948744The new views on the state of the gut microbiota in obesity and diabetes mellitus type 2Elena V. Pokrovskaya0Minara S. Shamkhalova1Marina V. Shestakova2Endocrinology Research CentreEndocrinology Research CentreEndocrinology Research CentreObesity is a worldwide problem of the last century, the prevalence of which has reached pandemic proportions in developed countries. Over the past few years, a considerable amount of data has been gathered, reporting a direct link between changes in gut microbiota and the development of obesity, as well as related diseases, primarily, diabetes mellitus type 2. The elaboration of optimal methods of prevention and treatment regimens of these diseases needs to structure the existing knowledge about the mechanisms of development of metabolic disorders, the role of intestinal microbiota in the latter and possible therapeutic “targets”. This review examines the role of microorganisms in the human body, with the main focus on the developmental origins of metabolic disorders using animal models and accumulated experience of research on their effects on the human body, and also discusses possible treatment options, including bariatric surgery, fecal microbiota transplantation, the use of pre- and probiotics and certain particular groups of glucose-lowering drugs.https://www.dia-endojournals.ru/jour/article/view/10194obesitygut microbiotadiabetes mellitus type 2bariatric surgeryglucose-loweringprobioticsfecal microbiota transplantation |
| spellingShingle | Elena V. Pokrovskaya Minara S. Shamkhalova Marina V. Shestakova The new views on the state of the gut microbiota in obesity and diabetes mellitus type 2 Сахарный диабет obesity gut microbiota diabetes mellitus type 2 bariatric surgery glucose-lowering probiotics fecal microbiota transplantation |
| title | The new views on the state of the gut microbiota in obesity and diabetes mellitus type 2 |
| title_full | The new views on the state of the gut microbiota in obesity and diabetes mellitus type 2 |
| title_fullStr | The new views on the state of the gut microbiota in obesity and diabetes mellitus type 2 |
| title_full_unstemmed | The new views on the state of the gut microbiota in obesity and diabetes mellitus type 2 |
| title_short | The new views on the state of the gut microbiota in obesity and diabetes mellitus type 2 |
| title_sort | new views on the state of the gut microbiota in obesity and diabetes mellitus type 2 |
| topic | obesity gut microbiota diabetes mellitus type 2 bariatric surgery glucose-lowering probiotics fecal microbiota transplantation |
| url | https://www.dia-endojournals.ru/jour/article/view/10194 |
| work_keys_str_mv | AT elenavpokrovskaya thenewviewsonthestateofthegutmicrobiotainobesityanddiabetesmellitustype2 AT minarasshamkhalova thenewviewsonthestateofthegutmicrobiotainobesityanddiabetesmellitustype2 AT marinavshestakova thenewviewsonthestateofthegutmicrobiotainobesityanddiabetesmellitustype2 AT elenavpokrovskaya newviewsonthestateofthegutmicrobiotainobesityanddiabetesmellitustype2 AT minarasshamkhalova newviewsonthestateofthegutmicrobiotainobesityanddiabetesmellitustype2 AT marinavshestakova newviewsonthestateofthegutmicrobiotainobesityanddiabetesmellitustype2 |