Complete remission in an advanced hepatocellular carcinoma patient with AXIN1 mutation after systemic therapy: A case report
Primary hepatocellular carcinoma (HCC) is a common malignancy with high morbidity and mortality. Despite progress in systemic therapies, survival in advanced HCC remains poor due to patient heterogeneity and individual differences, necessitating a personalized approach rather than relying solely on...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844025003901 |
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| author | Yihong Ran Xiaozhun Huang Xu Che Dong Chen |
| author_facet | Yihong Ran Xiaozhun Huang Xu Che Dong Chen |
| author_sort | Yihong Ran |
| collection | DOAJ |
| description | Primary hepatocellular carcinoma (HCC) is a common malignancy with high morbidity and mortality. Despite progress in systemic therapies, survival in advanced HCC remains poor due to patient heterogeneity and individual differences, necessitating a personalized approach rather than relying solely on guidelines. Here, we present an exceptional case study in which a systematic regimen without immune checkpoint inhibitors was chosen based on the patient's specific genetic test results. Remarkably effective with long-term survival benefits were observed as a result. This case underscores the importance of incorporating tumor profiling and personalized treatment plans, in addition to adhering to guidelines and standards, for delivering more efficacious and well-tolerated therapeutic options to patients with liver cancer. |
| format | Article |
| id | doaj-art-64651f848eba4f3a9e5157f26afd0412 |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-64651f848eba4f3a9e5157f26afd04122025-02-02T05:28:47ZengElsevierHeliyon2405-84402025-01-01112e42010Complete remission in an advanced hepatocellular carcinoma patient with AXIN1 mutation after systemic therapy: A case reportYihong Ran0Xiaozhun Huang1Xu Che2Dong Chen3National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, 518116, ChinaNational Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, 518116, ChinaCorresponding author.dr.chex@hotmail.com; National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, 518116, ChinaCorresponding author.; National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, 518116, ChinaPrimary hepatocellular carcinoma (HCC) is a common malignancy with high morbidity and mortality. Despite progress in systemic therapies, survival in advanced HCC remains poor due to patient heterogeneity and individual differences, necessitating a personalized approach rather than relying solely on guidelines. Here, we present an exceptional case study in which a systematic regimen without immune checkpoint inhibitors was chosen based on the patient's specific genetic test results. Remarkably effective with long-term survival benefits were observed as a result. This case underscores the importance of incorporating tumor profiling and personalized treatment plans, in addition to adhering to guidelines and standards, for delivering more efficacious and well-tolerated therapeutic options to patients with liver cancer.http://www.sciencedirect.com/science/article/pii/S2405844025003901Hepatocellular carcinomaSystemic therapyLiver biopsyHepatic arterial infusion chemotherapyClinical complete remission |
| spellingShingle | Yihong Ran Xiaozhun Huang Xu Che Dong Chen Complete remission in an advanced hepatocellular carcinoma patient with AXIN1 mutation after systemic therapy: A case report Heliyon Hepatocellular carcinoma Systemic therapy Liver biopsy Hepatic arterial infusion chemotherapy Clinical complete remission |
| title | Complete remission in an advanced hepatocellular carcinoma patient with AXIN1 mutation after systemic therapy: A case report |
| title_full | Complete remission in an advanced hepatocellular carcinoma patient with AXIN1 mutation after systemic therapy: A case report |
| title_fullStr | Complete remission in an advanced hepatocellular carcinoma patient with AXIN1 mutation after systemic therapy: A case report |
| title_full_unstemmed | Complete remission in an advanced hepatocellular carcinoma patient with AXIN1 mutation after systemic therapy: A case report |
| title_short | Complete remission in an advanced hepatocellular carcinoma patient with AXIN1 mutation after systemic therapy: A case report |
| title_sort | complete remission in an advanced hepatocellular carcinoma patient with axin1 mutation after systemic therapy a case report |
| topic | Hepatocellular carcinoma Systemic therapy Liver biopsy Hepatic arterial infusion chemotherapy Clinical complete remission |
| url | http://www.sciencedirect.com/science/article/pii/S2405844025003901 |
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