Adipose-Derived Cells (Stromal Vascular Fraction) Transplanted for Orthopedical or Neurological Purposes: Are They Safe Enough?
Although mesenchymal stem cells are used in numerous clinical trials, the safety of their application is still a matter of concern. We have analysed the clinical results of the autologous adipose-derived stem cell treatment (stromal vascular fraction (SVF) containing adipose-derived stem cells, endo...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/5762916 |
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| author | Katarzyna Siennicka Aleksandra Zolocinska Karolina Stepien Natalia Lubina-Dabrowska Marzena Maciagowska Ewa Zolocinska Anna Slysz Renata Piusinska-Macoch Slawomir Mazur Urszula Zdanowicz Robert Smigielski Adam Stepien Zygmunt Pojda |
| author_facet | Katarzyna Siennicka Aleksandra Zolocinska Karolina Stepien Natalia Lubina-Dabrowska Marzena Maciagowska Ewa Zolocinska Anna Slysz Renata Piusinska-Macoch Slawomir Mazur Urszula Zdanowicz Robert Smigielski Adam Stepien Zygmunt Pojda |
| author_sort | Katarzyna Siennicka |
| collection | DOAJ |
| description | Although mesenchymal stem cells are used in numerous clinical trials, the safety of their application is still a matter of concern. We have analysed the clinical results of the autologous adipose-derived stem cell treatment (stromal vascular fraction (SVF) containing adipose-derived stem cells, endothelial progenitors, and blood mononuclear cells) for orthopedic (cartilage, bone, tendon, or combined joint injuries) and neurologic (multiple sclerosis) diseases. Methods of adipose tissue collection, cell isolation and purification, and resulting cell numbers, viability, and morphology were considered, and patient’s age, sex, disease type, and method of cell administration (cell numbers per single application, treatment numbers and frequency, and methods of cell implantation) were analysed and searched for the unwanted clinical effects. Results of cellular therapy were compared retrospectively to those obtained with conventional medication without SVF application. SVF transplantation was always the accessory treatment of patients receiving “standard routine” therapies of their diseases. Clinical experiments were approved by the Bioethical Medical Committees supervising the centers where patients were hospitalised. The conclusion of the study is that none of the treated patients developed any serious adverse event, and autologous mesenchymal stem (stromal) cell clinical application is a safe procedure resulting in some beneficial clinical effects (not analysed in this study). |
| format | Article |
| id | doaj-art-6464e7b733db44469386a73056761d38 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-6464e7b733db44469386a73056761d382025-02-03T07:24:07ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/57629165762916Adipose-Derived Cells (Stromal Vascular Fraction) Transplanted for Orthopedical or Neurological Purposes: Are They Safe Enough?Katarzyna Siennicka0Aleksandra Zolocinska1Karolina Stepien2Natalia Lubina-Dabrowska3Marzena Maciagowska4Ewa Zolocinska5Anna Slysz6Renata Piusinska-Macoch7Slawomir Mazur8Urszula Zdanowicz9Robert Smigielski10Adam Stepien11Zygmunt Pojda12Department of Regenerative Medicine, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Roentgena 5, 02-781 Warsaw, PolandDepartment of Regenerative Medicine, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Roentgena 5, 02-781 Warsaw, PolandDepartment of Orthopedics, Carolina Medical Center, Pory 78, 02-001 Warsaw, PolandDepartment of Neurology, Military Institute of Medicine, Szaserow 128, 04-141 Warsaw, PolandDepartment of Neurology, Military Institute of Medicine, Szaserow 128, 04-141 Warsaw, PolandDepartment of Regenerative Medicine, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Roentgena 5, 02-781 Warsaw, PolandDepartment of Regenerative Medicine, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Roentgena 5, 02-781 Warsaw, PolandDepartment of Neurology, Military Institute of Medicine, Szaserow 128, 04-141 Warsaw, PolandDepartment of Regenerative Medicine, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Roentgena 5, 02-781 Warsaw, PolandDepartment of Orthopedics, Carolina Medical Center, Pory 78, 02-001 Warsaw, PolandDepartment of Orthopedics, Carolina Medical Center, Pory 78, 02-001 Warsaw, PolandDepartment of Neurology, Military Institute of Medicine, Szaserow 128, 04-141 Warsaw, PolandDepartment of Regenerative Medicine, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Roentgena 5, 02-781 Warsaw, PolandAlthough mesenchymal stem cells are used in numerous clinical trials, the safety of their application is still a matter of concern. We have analysed the clinical results of the autologous adipose-derived stem cell treatment (stromal vascular fraction (SVF) containing adipose-derived stem cells, endothelial progenitors, and blood mononuclear cells) for orthopedic (cartilage, bone, tendon, or combined joint injuries) and neurologic (multiple sclerosis) diseases. Methods of adipose tissue collection, cell isolation and purification, and resulting cell numbers, viability, and morphology were considered, and patient’s age, sex, disease type, and method of cell administration (cell numbers per single application, treatment numbers and frequency, and methods of cell implantation) were analysed and searched for the unwanted clinical effects. Results of cellular therapy were compared retrospectively to those obtained with conventional medication without SVF application. SVF transplantation was always the accessory treatment of patients receiving “standard routine” therapies of their diseases. Clinical experiments were approved by the Bioethical Medical Committees supervising the centers where patients were hospitalised. The conclusion of the study is that none of the treated patients developed any serious adverse event, and autologous mesenchymal stem (stromal) cell clinical application is a safe procedure resulting in some beneficial clinical effects (not analysed in this study).http://dx.doi.org/10.1155/2016/5762916 |
| spellingShingle | Katarzyna Siennicka Aleksandra Zolocinska Karolina Stepien Natalia Lubina-Dabrowska Marzena Maciagowska Ewa Zolocinska Anna Slysz Renata Piusinska-Macoch Slawomir Mazur Urszula Zdanowicz Robert Smigielski Adam Stepien Zygmunt Pojda Adipose-Derived Cells (Stromal Vascular Fraction) Transplanted for Orthopedical or Neurological Purposes: Are They Safe Enough? Stem Cells International |
| title | Adipose-Derived Cells (Stromal Vascular Fraction) Transplanted for Orthopedical or Neurological Purposes: Are They Safe Enough? |
| title_full | Adipose-Derived Cells (Stromal Vascular Fraction) Transplanted for Orthopedical or Neurological Purposes: Are They Safe Enough? |
| title_fullStr | Adipose-Derived Cells (Stromal Vascular Fraction) Transplanted for Orthopedical or Neurological Purposes: Are They Safe Enough? |
| title_full_unstemmed | Adipose-Derived Cells (Stromal Vascular Fraction) Transplanted for Orthopedical or Neurological Purposes: Are They Safe Enough? |
| title_short | Adipose-Derived Cells (Stromal Vascular Fraction) Transplanted for Orthopedical or Neurological Purposes: Are They Safe Enough? |
| title_sort | adipose derived cells stromal vascular fraction transplanted for orthopedical or neurological purposes are they safe enough |
| url | http://dx.doi.org/10.1155/2016/5762916 |
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