Intra-abdominal pressure and residual renal function decline in peritoneal dialysis: a threshold-based investigation
Background The potential impact of elevated intra-abdominal pressure (IAP) on residual renal function (RRF) has not been determined. The objective of this study was to investigate the relationship between IAP and the rate of RRF decline in newly initiated peritoneal dialysis (PD) patients, and to id...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2312535 |
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| author | Jingjing Zhang Lei Song Zhongwei Ma Lina Sun Xiaoqing Wang Duanyan Liu Feng Huang Yulin Man |
| author_facet | Jingjing Zhang Lei Song Zhongwei Ma Lina Sun Xiaoqing Wang Duanyan Liu Feng Huang Yulin Man |
| author_sort | Jingjing Zhang |
| collection | DOAJ |
| description | Background The potential impact of elevated intra-abdominal pressure (IAP) on residual renal function (RRF) has not been determined. The objective of this study was to investigate the relationship between IAP and the rate of RRF decline in newly initiated peritoneal dialysis (PD) patients, and to identify the optimal IAP threshold value for delaying the deterioration of RRF.Methods A cohort of 62 newly initiated PD patients who completed both 6- and 12-month follow-up evaluations was obtained using the Durand method. A logistic regression model was used to identify variables associated with a rapid decline in RRF. Receiver operating characteristic (ROC) curves were generated to determine the optimal threshold value. Another retrospective cohort analysis was performed to validate the identified critical value.Results For each 1 cmH2O increase in IAP, the risk of a rapid decline in the RRF increased by a factor of 1.679. Subsequent analysis revealed that patients in the high IAP group had more significant decreases in residual renal estimated glomerular filtration rate (eGFR) (Z = −3.694, p < 0.001) and urine volume (Z = −3.121, p < 0.001) than did those in the non-high IAP group. Furthermore, an IAP ≥15.65 cmH2O was a robust discriminator for the prediction of the rate of RRF decline.Conclusion Patients in the high IAP group experienced a more rapid decline in RRF. Additionally, an optimal critical pressure of 15.65 cmH2O was identified for predicting the rate of RRF decline. IAP, as one of the factors contributing to the rapid decline in RRF in the first year of PD, should be given due attention. |
| format | Article |
| id | doaj-art-6464b763486543ddab08ef78d60f6bb2 |
| institution | Kabale University |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-6464b763486543ddab08ef78d60f6bb22025-01-23T04:17:48ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492024-12-0146110.1080/0886022X.2024.2312535Intra-abdominal pressure and residual renal function decline in peritoneal dialysis: a threshold-based investigationJingjing Zhang0Lei Song1Zhongwei Ma2Lina Sun3Xiaoqing Wang4Duanyan Liu5Feng Huang6Yulin Man7Graduate School of Jinzhou Medical University, Jinzhou, PR ChinaDepartment of Nephrology, Linyi People’s Hospital, Linyi, PR ChinaDepartment of Nephrology, Linyi People’s Hospital, Linyi, PR ChinaDepartment of Nephrology, Linyi People’s Hospital, Linyi, PR ChinaDepartment of Nephrology, Linyi People’s Hospital, Linyi, PR ChinaDepartment of Nephrology, Linyi People’s Hospital, Linyi, PR ChinaDepartment of Nephrology, Linyi People’s Hospital, Linyi, PR ChinaDepartment of Nephrology, Linyi People’s Hospital, Linyi, PR ChinaBackground The potential impact of elevated intra-abdominal pressure (IAP) on residual renal function (RRF) has not been determined. The objective of this study was to investigate the relationship between IAP and the rate of RRF decline in newly initiated peritoneal dialysis (PD) patients, and to identify the optimal IAP threshold value for delaying the deterioration of RRF.Methods A cohort of 62 newly initiated PD patients who completed both 6- and 12-month follow-up evaluations was obtained using the Durand method. A logistic regression model was used to identify variables associated with a rapid decline in RRF. Receiver operating characteristic (ROC) curves were generated to determine the optimal threshold value. Another retrospective cohort analysis was performed to validate the identified critical value.Results For each 1 cmH2O increase in IAP, the risk of a rapid decline in the RRF increased by a factor of 1.679. Subsequent analysis revealed that patients in the high IAP group had more significant decreases in residual renal estimated glomerular filtration rate (eGFR) (Z = −3.694, p < 0.001) and urine volume (Z = −3.121, p < 0.001) than did those in the non-high IAP group. Furthermore, an IAP ≥15.65 cmH2O was a robust discriminator for the prediction of the rate of RRF decline.Conclusion Patients in the high IAP group experienced a more rapid decline in RRF. Additionally, an optimal critical pressure of 15.65 cmH2O was identified for predicting the rate of RRF decline. IAP, as one of the factors contributing to the rapid decline in RRF in the first year of PD, should be given due attention.https://www.tandfonline.com/doi/10.1080/0886022X.2024.2312535Peritoneal dialysisintra-abdominal pressureresidual renal function |
| spellingShingle | Jingjing Zhang Lei Song Zhongwei Ma Lina Sun Xiaoqing Wang Duanyan Liu Feng Huang Yulin Man Intra-abdominal pressure and residual renal function decline in peritoneal dialysis: a threshold-based investigation Renal Failure Peritoneal dialysis intra-abdominal pressure residual renal function |
| title | Intra-abdominal pressure and residual renal function decline in peritoneal dialysis: a threshold-based investigation |
| title_full | Intra-abdominal pressure and residual renal function decline in peritoneal dialysis: a threshold-based investigation |
| title_fullStr | Intra-abdominal pressure and residual renal function decline in peritoneal dialysis: a threshold-based investigation |
| title_full_unstemmed | Intra-abdominal pressure and residual renal function decline in peritoneal dialysis: a threshold-based investigation |
| title_short | Intra-abdominal pressure and residual renal function decline in peritoneal dialysis: a threshold-based investigation |
| title_sort | intra abdominal pressure and residual renal function decline in peritoneal dialysis a threshold based investigation |
| topic | Peritoneal dialysis intra-abdominal pressure residual renal function |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2312535 |
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