Curcumin-enhanced NIR-II-responsive gold nanobipyramids for targeted HSP 90 inhibition
Blockade of heat shock protein 90 (HSP90) expression in multimodal synergistic therapy has a great prospect for cancer treatment. Nanomaterials combined with bioinformatic analysis provides accurate guidance for the design of anti-HSP90 nanomedicines. Herein, a NIR-II-responsive nanoplatform was dev...
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Elsevier
2025-04-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006425000997 |
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| author | Zhenying Diao Youcheng Liang Yong Liu Dou Zhang Long Qiu Jianbo Sun Qiaoyou Lu Yanlei Liu Daxiang Cui Ting Yin |
| author_facet | Zhenying Diao Youcheng Liang Yong Liu Dou Zhang Long Qiu Jianbo Sun Qiaoyou Lu Yanlei Liu Daxiang Cui Ting Yin |
| author_sort | Zhenying Diao |
| collection | DOAJ |
| description | Blockade of heat shock protein 90 (HSP90) expression in multimodal synergistic therapy has a great prospect for cancer treatment. Nanomaterials combined with bioinformatic analysis provides accurate guidance for the design of anti-HSP90 nanomedicines. Herein, a NIR-II-responsive nanoplatform was developed under bioinformatics guided to effectly inhibit HSP90 for enhanced synergistic mild-photothermal chemotherapy without any notable tissue damage. The nanoplatforms were assembled from NIR-II-responsive gold nanobipyramids (GNBs) combined with curcumin (Cur) via hydrophobic-hydrophobic interactions and hydrogen bonds. On the basis of drug discovery and network pharmacology, we found that Cur has impressive anti-HSP90 capability and analyzed its therapeutic mechanism against NSCLC. Under the irradiation of NIR-II light, the obtained GNBs-Cur blocked the expression of HPS90 and inhibited related antiapoptotic pathways, thus enhancing the mild PTT of GNBs under 1064 nm laser irradiation. Meanwhile, Cur served as chemotherapeutic agents to induce apoptosis in tumor cells. In vivo photoacoustic imaging-guided, GNBs-Cur achieved effective tumor elimination through mild-photothermal chemotherapy without systemic toxicity. Overall, this work provides a new therapeutic modality paradigm for potential NSCLC treatment on the basis of synergistic therapies. |
| format | Article |
| id | doaj-art-6457d0ecedc24f778f3d878a840838bd |
| institution | Kabale University |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-6457d0ecedc24f778f3d878a840838bd2025-02-06T05:12:41ZengElsevierMaterials Today Bio2590-00642025-04-0131101541Curcumin-enhanced NIR-II-responsive gold nanobipyramids for targeted HSP 90 inhibitionZhenying Diao0Youcheng Liang1Yong Liu2Dou Zhang3Long Qiu4Jianbo Sun5Qiaoyou Lu6Yanlei Liu7Daxiang Cui8Ting Yin9Research Center of Nano Technology and Application Engineering, The First Dongguan Affiliated Hospital, School of Pharmacy, Guangdong Medical University, Dongguan, 523808, Guangdong, PR China; Dongguan Research Center for Biomedical Nano Engineering Technology Research, Guangdong Medical University, Dongguan, 523808, Guangdong, PR ChinaScience and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405, Guangdong, PR ChinaResearch Center of Nano Technology and Application Engineering, The First Dongguan Affiliated Hospital, School of Pharmacy, Guangdong Medical University, Dongguan, 523808, Guangdong, PR China; Dongguan Research Center for Biomedical Nano Engineering Technology Research, Guangdong Medical University, Dongguan, 523808, Guangdong, PR ChinaResearch Center of Nano Technology and Application Engineering, The First Dongguan Affiliated Hospital, School of Pharmacy, Guangdong Medical University, Dongguan, 523808, Guangdong, PR China; Dongguan Research Center for Biomedical Nano Engineering Technology Research, Guangdong Medical University, Dongguan, 523808, Guangdong, PR ChinaResearch Center of Nano Technology and Application Engineering, The First Dongguan Affiliated Hospital, School of Pharmacy, Guangdong Medical University, Dongguan, 523808, Guangdong, PR China; Dongguan Research Center for Biomedical Nano Engineering Technology Research, Guangdong Medical University, Dongguan, 523808, Guangdong, PR ChinaResearch Center of Nano Technology and Application Engineering, The First Dongguan Affiliated Hospital, School of Pharmacy, Guangdong Medical University, Dongguan, 523808, Guangdong, PR ChinaResearch Center of Nano Technology and Application Engineering, The First Dongguan Affiliated Hospital, School of Pharmacy, Guangdong Medical University, Dongguan, 523808, Guangdong, PR China; Dongguan Research Center for Biomedical Nano Engineering Technology Research, Guangdong Medical University, Dongguan, 523808, Guangdong, PR ChinaResearch Center of Nano Technology and Application Engineering, The First Dongguan Affiliated Hospital, School of Pharmacy, Guangdong Medical University, Dongguan, 523808, Guangdong, PR China; School of Sensing Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, PR China; Corresponding author. Dongguan Research Center for Biomedical Nano Engineering Technology Research, Guangdong Medical University, Dongguan, 523808, Guangdong, PR China.Research Center of Nano Technology and Application Engineering, The First Dongguan Affiliated Hospital, School of Pharmacy, Guangdong Medical University, Dongguan, 523808, Guangdong, PR China; School of Sensing Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, PR China; Corresponding author. Research Center of Nano Technology and Application Engineering, The First Dongguan Affiliated Hospital, School of Pharmacy, Guangdong Medical University, Dongguan, 523808, Guangdong, PR China.Research Center of Nano Technology and Application Engineering, The First Dongguan Affiliated Hospital, School of Pharmacy, Guangdong Medical University, Dongguan, 523808, Guangdong, PR China; Dongguan Research Center for Biomedical Nano Engineering Technology Research, Guangdong Medical University, Dongguan, 523808, Guangdong, PR China; Corresponding author. Research Center of Nano Technology and Application Engineering, The First Dongguan Affiliated Hospital, School of Pharmacy, Guangdong Medical University, Dongguan, 523808, Guangdong, PR China.Blockade of heat shock protein 90 (HSP90) expression in multimodal synergistic therapy has a great prospect for cancer treatment. Nanomaterials combined with bioinformatic analysis provides accurate guidance for the design of anti-HSP90 nanomedicines. Herein, a NIR-II-responsive nanoplatform was developed under bioinformatics guided to effectly inhibit HSP90 for enhanced synergistic mild-photothermal chemotherapy without any notable tissue damage. The nanoplatforms were assembled from NIR-II-responsive gold nanobipyramids (GNBs) combined with curcumin (Cur) via hydrophobic-hydrophobic interactions and hydrogen bonds. On the basis of drug discovery and network pharmacology, we found that Cur has impressive anti-HSP90 capability and analyzed its therapeutic mechanism against NSCLC. Under the irradiation of NIR-II light, the obtained GNBs-Cur blocked the expression of HPS90 and inhibited related antiapoptotic pathways, thus enhancing the mild PTT of GNBs under 1064 nm laser irradiation. Meanwhile, Cur served as chemotherapeutic agents to induce apoptosis in tumor cells. In vivo photoacoustic imaging-guided, GNBs-Cur achieved effective tumor elimination through mild-photothermal chemotherapy without systemic toxicity. Overall, this work provides a new therapeutic modality paradigm for potential NSCLC treatment on the basis of synergistic therapies.http://www.sciencedirect.com/science/article/pii/S2590006425000997Heat shock protein 90 blockadeBioinformatic predictionNIR-II-Responsive gold nanobipyramidsMild PTTSynergistic therapies |
| spellingShingle | Zhenying Diao Youcheng Liang Yong Liu Dou Zhang Long Qiu Jianbo Sun Qiaoyou Lu Yanlei Liu Daxiang Cui Ting Yin Curcumin-enhanced NIR-II-responsive gold nanobipyramids for targeted HSP 90 inhibition Materials Today Bio Heat shock protein 90 blockade Bioinformatic prediction NIR-II-Responsive gold nanobipyramids Mild PTT Synergistic therapies |
| title | Curcumin-enhanced NIR-II-responsive gold nanobipyramids for targeted HSP 90 inhibition |
| title_full | Curcumin-enhanced NIR-II-responsive gold nanobipyramids for targeted HSP 90 inhibition |
| title_fullStr | Curcumin-enhanced NIR-II-responsive gold nanobipyramids for targeted HSP 90 inhibition |
| title_full_unstemmed | Curcumin-enhanced NIR-II-responsive gold nanobipyramids for targeted HSP 90 inhibition |
| title_short | Curcumin-enhanced NIR-II-responsive gold nanobipyramids for targeted HSP 90 inhibition |
| title_sort | curcumin enhanced nir ii responsive gold nanobipyramids for targeted hsp 90 inhibition |
| topic | Heat shock protein 90 blockade Bioinformatic prediction NIR-II-Responsive gold nanobipyramids Mild PTT Synergistic therapies |
| url | http://www.sciencedirect.com/science/article/pii/S2590006425000997 |
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