NAFLD, Estrogens, and Physical Exercise: The Animal Model
One segment of the population that is particularly inclined to liver fat accumulation is postmenopausal women. Although nonalcoholic hepatic steatosis is more common in men than in women, after menopause there is a reversal in gender distribution. At the present time, weight loss and exercise are re...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Nutrition and Metabolism |
| Online Access: | http://dx.doi.org/10.1155/2012/914938 |
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| author | Jean-Marc Lavoie Abdolnaser Pighon |
| author_facet | Jean-Marc Lavoie Abdolnaser Pighon |
| author_sort | Jean-Marc Lavoie |
| collection | DOAJ |
| description | One segment of the population that is particularly inclined to liver fat accumulation is postmenopausal women. Although nonalcoholic hepatic steatosis is more common in men than in women, after menopause there is a reversal in gender distribution. At the present time, weight loss and exercise are regarded as first line treatments for NAFLD in postmenopausal women, as it is the case for the management of metabolic syndrome. In recent years, there has been substantial evidence coming mostly from the use of the animal model, that indeed estrogens withdrawal is associated with modifications of molecular markers favouring the activity of metabolic pathways ultimately leading to liver fat accumulation. In addition, the use of the animal model has provided physiological and molecular evidence that exercise training provides estrogens-like protective effects on liver fat accumulation and its consequences. The purpose of the present paper is to present information relative to the development of a state of NAFLD resulting from the absence of estrogens and the role of exercise training, emphasizing on the contribution of the animal model on these issues. |
| format | Article |
| id | doaj-art-645676d50d104bd08ed7d024c09c5784 |
| institution | Kabale University |
| issn | 2090-0724 2090-0732 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nutrition and Metabolism |
| spelling | doaj-art-645676d50d104bd08ed7d024c09c57842025-02-03T05:59:27ZengWileyJournal of Nutrition and Metabolism2090-07242090-07322012-01-01201210.1155/2012/914938914938NAFLD, Estrogens, and Physical Exercise: The Animal ModelJean-Marc Lavoie0Abdolnaser Pighon1Department of Kinesiology, University of Montreal, Montréal, QC, H3C 3J7, CanadaDepartment of Kinesiology, University of Montreal, Montréal, QC, H3C 3J7, CanadaOne segment of the population that is particularly inclined to liver fat accumulation is postmenopausal women. Although nonalcoholic hepatic steatosis is more common in men than in women, after menopause there is a reversal in gender distribution. At the present time, weight loss and exercise are regarded as first line treatments for NAFLD in postmenopausal women, as it is the case for the management of metabolic syndrome. In recent years, there has been substantial evidence coming mostly from the use of the animal model, that indeed estrogens withdrawal is associated with modifications of molecular markers favouring the activity of metabolic pathways ultimately leading to liver fat accumulation. In addition, the use of the animal model has provided physiological and molecular evidence that exercise training provides estrogens-like protective effects on liver fat accumulation and its consequences. The purpose of the present paper is to present information relative to the development of a state of NAFLD resulting from the absence of estrogens and the role of exercise training, emphasizing on the contribution of the animal model on these issues.http://dx.doi.org/10.1155/2012/914938 |
| spellingShingle | Jean-Marc Lavoie Abdolnaser Pighon NAFLD, Estrogens, and Physical Exercise: The Animal Model Journal of Nutrition and Metabolism |
| title | NAFLD, Estrogens, and Physical Exercise: The Animal Model |
| title_full | NAFLD, Estrogens, and Physical Exercise: The Animal Model |
| title_fullStr | NAFLD, Estrogens, and Physical Exercise: The Animal Model |
| title_full_unstemmed | NAFLD, Estrogens, and Physical Exercise: The Animal Model |
| title_short | NAFLD, Estrogens, and Physical Exercise: The Animal Model |
| title_sort | nafld estrogens and physical exercise the animal model |
| url | http://dx.doi.org/10.1155/2012/914938 |
| work_keys_str_mv | AT jeanmarclavoie nafldestrogensandphysicalexercisetheanimalmodel AT abdolnaserpighon nafldestrogensandphysicalexercisetheanimalmodel |