Detection of macular and peripheral ocular microvascular changes after carotid artery revascularization using widefield SS-OCTA
PurposeThis study aims to investigate microvascular changes in the macular and peripheral regions, as well as alterations in the foveal avascular zone (FAZ) of the ipsilateral eye using widefield swept-source optical coherence tomography angiography (SS-OCTA) in patients with severe carotid artery s...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1530867/full |
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| author | Ting Luo Lu Wang Li Zhang |
| author_facet | Ting Luo Lu Wang Li Zhang |
| author_sort | Ting Luo |
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| description | PurposeThis study aims to investigate microvascular changes in the macular and peripheral regions, as well as alterations in the foveal avascular zone (FAZ) of the ipsilateral eye using widefield swept-source optical coherence tomography angiography (SS-OCTA) in patients with severe carotid artery stenosis (SCAS) after carotid artery revascularization (CAR).DesignThis study employed a prospective study design.MethodsSCAS patients were examined using widefield SS-OCTA, which covered an area of 16 × 16 mm centered on the fovea. These examinations were conducted both before and after CAR to assess changes in retinal and choroidal blood flow in the macular and peripheral regions, as well as alterations in the characteristics of the FAZ.ResultsA total of 56 patients and their corresponding 56 ipsilateral eyes were included in this study. In the macular area, a significant increase in the vessel density of the retinal superficial vascular complex (VDRSVC) was found, while a significant decrease was noted in the vessel density of the retinal deep vascular complex (VDRDVC) after CAR. Additionally, both the area and circumference of the FAZ decreased significantly after CAR. In the peripheral regions, significant increases were detected in both VDRSVC and the three-dimensional choroidal vascularity index (3D-CVI) post-CAR.ConclusionThe findings of this study demonstrated that CAR can improve perfusion in both the macular and peripheral fundus and lead to a decreased area and circumference of the FAZ in the ipsilateral eye. The observed decrease in the VDRDVC after CAR may be attributed to microvascular embolization and ischemia within the deep capillary plexus (DCP). |
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| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Medicine |
| spelling | doaj-art-64463eb663b94176a1b2a2e54708deb62025-01-22T07:14:06ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-01-011210.3389/fmed.2025.15308671530867Detection of macular and peripheral ocular microvascular changes after carotid artery revascularization using widefield SS-OCTATing Luo0Lu Wang1Li Zhang2Department of Ophthalmology, The Third People’s Hospital of Chengdu, Chengdu, ChinaDepartment of Ophthalmology, The Second People’s Hospital of Chengdu, Chengdu, ChinaDepartment of Ophthalmology, West China Hospital, Sichuan University, Chengdu, ChinaPurposeThis study aims to investigate microvascular changes in the macular and peripheral regions, as well as alterations in the foveal avascular zone (FAZ) of the ipsilateral eye using widefield swept-source optical coherence tomography angiography (SS-OCTA) in patients with severe carotid artery stenosis (SCAS) after carotid artery revascularization (CAR).DesignThis study employed a prospective study design.MethodsSCAS patients were examined using widefield SS-OCTA, which covered an area of 16 × 16 mm centered on the fovea. These examinations were conducted both before and after CAR to assess changes in retinal and choroidal blood flow in the macular and peripheral regions, as well as alterations in the characteristics of the FAZ.ResultsA total of 56 patients and their corresponding 56 ipsilateral eyes were included in this study. In the macular area, a significant increase in the vessel density of the retinal superficial vascular complex (VDRSVC) was found, while a significant decrease was noted in the vessel density of the retinal deep vascular complex (VDRDVC) after CAR. Additionally, both the area and circumference of the FAZ decreased significantly after CAR. In the peripheral regions, significant increases were detected in both VDRSVC and the three-dimensional choroidal vascularity index (3D-CVI) post-CAR.ConclusionThe findings of this study demonstrated that CAR can improve perfusion in both the macular and peripheral fundus and lead to a decreased area and circumference of the FAZ in the ipsilateral eye. The observed decrease in the VDRDVC after CAR may be attributed to microvascular embolization and ischemia within the deep capillary plexus (DCP).https://www.frontiersin.org/articles/10.3389/fmed.2025.1530867/fullcarotid artery revascularizationSSOCTAretinal microvasculaturefoveal avascular zone (FAZ)carotid artery stenosis (CAS) |
| spellingShingle | Ting Luo Lu Wang Li Zhang Detection of macular and peripheral ocular microvascular changes after carotid artery revascularization using widefield SS-OCTA Frontiers in Medicine carotid artery revascularization SSOCTA retinal microvasculature foveal avascular zone (FAZ) carotid artery stenosis (CAS) |
| title | Detection of macular and peripheral ocular microvascular changes after carotid artery revascularization using widefield SS-OCTA |
| title_full | Detection of macular and peripheral ocular microvascular changes after carotid artery revascularization using widefield SS-OCTA |
| title_fullStr | Detection of macular and peripheral ocular microvascular changes after carotid artery revascularization using widefield SS-OCTA |
| title_full_unstemmed | Detection of macular and peripheral ocular microvascular changes after carotid artery revascularization using widefield SS-OCTA |
| title_short | Detection of macular and peripheral ocular microvascular changes after carotid artery revascularization using widefield SS-OCTA |
| title_sort | detection of macular and peripheral ocular microvascular changes after carotid artery revascularization using widefield ss octa |
| topic | carotid artery revascularization SSOCTA retinal microvasculature foveal avascular zone (FAZ) carotid artery stenosis (CAS) |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1530867/full |
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