Cancer Stem Cells: From an Insight into the Basics to Recent Advances and Therapeutic Targeting
Cancer is characterized by an abnormal growth of the cells in an uncontrolled manner. These cells have the potential to invade and can eventually turn into malignancy, leading to highly fatal forms of tumor. Small subpopulations of cancer cells that are long-lived with the potential of excessive sel...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2022/9653244 |
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| author | Shweta Bisht Manisha Nigam Shyam S. Kunjwal Plygun Sergey Abhay Prakash Mishra Javad Sharifi-Rad |
| author_facet | Shweta Bisht Manisha Nigam Shyam S. Kunjwal Plygun Sergey Abhay Prakash Mishra Javad Sharifi-Rad |
| author_sort | Shweta Bisht |
| collection | DOAJ |
| description | Cancer is characterized by an abnormal growth of the cells in an uncontrolled manner. These cells have the potential to invade and can eventually turn into malignancy, leading to highly fatal forms of tumor. Small subpopulations of cancer cells that are long-lived with the potential of excessive self-renewal and tumor formation are called cancer stem cells (CSCs) or cancer-initiating cells or tumor stem cells. CSCs can be found in tissues, such as breast, brain, lung, liver, ovary, and testis; however, their origin is still a matter of debate. These cells can differentiate and possess self-renewal capacity maintained by numerous intracellular signal transduction pathways, such as the Wnt/β-catenin signaling, Notch signaling, transforming growth factor-β signaling, and Hedgehog signaling. They can also contribute to numerous malignancies and are an important reason for tumor recurrence and metastasis because they are resistant to the known therapeutic strategies that mainly target the bulk of the tumor cells. This review contains collected and compiled information after analyzing published works of the last three decades. The goal was to gather information of recent breakthroughs related to CSCs, strategies to target CSCs’ niche (e.g., nanotechnology with tumor biology), and their signaling pathways for cancer therapy. Moreover, the role of metformin, an antidiabetic drug, acting as a chemotherapeutic agent on CSCs by inhibiting cellular transformation and its selective killing is also addressed. |
| format | Article |
| id | doaj-art-643b2dbdfc1941ef8d505401df079166 |
| institution | Kabale University |
| issn | 1687-9678 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-643b2dbdfc1941ef8d505401df0791662025-08-20T03:34:25ZengWileyStem Cells International1687-96782022-01-01202210.1155/2022/9653244Cancer Stem Cells: From an Insight into the Basics to Recent Advances and Therapeutic TargetingShweta Bisht0Manisha Nigam1Shyam S. Kunjwal2Plygun Sergey3Abhay Prakash Mishra4Javad Sharifi-Rad5Department of BiochemistryDepartment of BiochemistryDepartment of ZoologyEuropean Society of Clinical Microbiology and Infectious DiseasesLaboratory of Biocontrol and Antimicrobial ResistanceFacultad de MedicinaCancer is characterized by an abnormal growth of the cells in an uncontrolled manner. These cells have the potential to invade and can eventually turn into malignancy, leading to highly fatal forms of tumor. Small subpopulations of cancer cells that are long-lived with the potential of excessive self-renewal and tumor formation are called cancer stem cells (CSCs) or cancer-initiating cells or tumor stem cells. CSCs can be found in tissues, such as breast, brain, lung, liver, ovary, and testis; however, their origin is still a matter of debate. These cells can differentiate and possess self-renewal capacity maintained by numerous intracellular signal transduction pathways, such as the Wnt/β-catenin signaling, Notch signaling, transforming growth factor-β signaling, and Hedgehog signaling. They can also contribute to numerous malignancies and are an important reason for tumor recurrence and metastasis because they are resistant to the known therapeutic strategies that mainly target the bulk of the tumor cells. This review contains collected and compiled information after analyzing published works of the last three decades. The goal was to gather information of recent breakthroughs related to CSCs, strategies to target CSCs’ niche (e.g., nanotechnology with tumor biology), and their signaling pathways for cancer therapy. Moreover, the role of metformin, an antidiabetic drug, acting as a chemotherapeutic agent on CSCs by inhibiting cellular transformation and its selective killing is also addressed.http://dx.doi.org/10.1155/2022/9653244 |
| spellingShingle | Shweta Bisht Manisha Nigam Shyam S. Kunjwal Plygun Sergey Abhay Prakash Mishra Javad Sharifi-Rad Cancer Stem Cells: From an Insight into the Basics to Recent Advances and Therapeutic Targeting Stem Cells International |
| title | Cancer Stem Cells: From an Insight into the Basics to Recent Advances and Therapeutic Targeting |
| title_full | Cancer Stem Cells: From an Insight into the Basics to Recent Advances and Therapeutic Targeting |
| title_fullStr | Cancer Stem Cells: From an Insight into the Basics to Recent Advances and Therapeutic Targeting |
| title_full_unstemmed | Cancer Stem Cells: From an Insight into the Basics to Recent Advances and Therapeutic Targeting |
| title_short | Cancer Stem Cells: From an Insight into the Basics to Recent Advances and Therapeutic Targeting |
| title_sort | cancer stem cells from an insight into the basics to recent advances and therapeutic targeting |
| url | http://dx.doi.org/10.1155/2022/9653244 |
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