Optineurin overexpression ameliorates neurodegeneration through regulating neuroinflammation and mitochondrial quality in a murine model of amyotrophic lateral sclerosis

Optineurin overexpression ameliorates neurodegeneration through regulating neuroinflammation and mitochondrial quality in a murine model of amyotrophic lateral sclerosis

IntroductionAmyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the loss of motor neurons (MNs). Genetic mutations in Optineurin (OPTN) and Superoxide Dismutase 1 (SOD1) have been identified as causal factors for ALS. OPTN immunopositive inclusions have been confirmed...

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Main Authors: Shumin Zhao, Ranran Chen, Yi An, Yali Zhang, Cheng Ma, Ying Gao, Yanchao Lu, Fei Yang, Xue Bai, Jingjing Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Aging Neuroscience
Subjects:
amyotrophic lateral sclerosis
apoptosis
mitochondrial quality
neuroinflammation
optineurin
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2025.1522073/full
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