Inflammatory biomarkers profiles and cognition among older adults
Abstract Inflammation plays a major role in cognitive aging. Most studies on peripheral inflammation and cognitive aging focused on selected major inflammatory biomarkers. However, inflammatory markers are regulated and influenced by each other, and it is therefore important to consider a more compr...
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Nature Portfolio
2025-01-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-86309-z |
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| author | Aline Thomas Jing Guo Dolly Reyes-Dumeyer Danurys Sanchez Nikolaos Scarmeas Jennifer J. Manly Adam M. Brickman Rafael A. Lantigua Richard Mayeux Yian Gu |
| author_facet | Aline Thomas Jing Guo Dolly Reyes-Dumeyer Danurys Sanchez Nikolaos Scarmeas Jennifer J. Manly Adam M. Brickman Rafael A. Lantigua Richard Mayeux Yian Gu |
| author_sort | Aline Thomas |
| collection | DOAJ |
| description | Abstract Inflammation plays a major role in cognitive aging. Most studies on peripheral inflammation and cognitive aging focused on selected major inflammatory biomarkers. However, inflammatory markers are regulated and influenced by each other, and it is therefore important to consider a more comprehensive panel of markers to better capture diverse immune pathways and characterize the overall inflammatory profile of individuals. We explored 23 circulating inflammatory biomarkers using data from 1,743 participants without dementia (≥ 65 years-old) from the community-based, multiethnic Washington Heights Inwood Columbia Aging Project. Using principal component analysis (PCA), we developed six inflammatory profiles (PC-1 to PC-6) based on these 23 biomarkers and tested the association of resulting inflammatory profile with cognitive decline, over up to 12 years of follow-up. PC-1 described a pro-inflammatory profile characterized by high positive loadings for pro-inflammatory biomarkers. A higher PC-1 score was associated with lower baseline cognitive performances. No association of this profile with cognitive decline was observed in longitudinal analysis. However, PC-5 characterized by high PDGF-AA and RANTES was associated with a faster cognitive decline. Among older adults, a circulating pro-inflammatory immune profile is associated with lower baseline cognitive performance, and some specific pro-inflammatory cytokines might be associated with faster cognitive decline. |
| format | Article |
| id | doaj-art-64219698aa7c48af88c7a84e4509af81 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-64219698aa7c48af88c7a84e4509af812025-01-19T12:18:23ZengNature PortfolioScientific Reports2045-23222025-01-0115111110.1038/s41598-025-86309-zInflammatory biomarkers profiles and cognition among older adultsAline Thomas0Jing Guo1Dolly Reyes-Dumeyer2Danurys Sanchez3Nikolaos Scarmeas4Jennifer J. Manly5Adam M. Brickman6Rafael A. Lantigua7Richard Mayeux8Yian Gu9Taub Institute for Research On Alzheimer’s Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia UniversityTaub Institute for Research On Alzheimer’s Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia UniversityTaub Institute for Research On Alzheimer’s Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia UniversityTaub Institute for Research On Alzheimer’s Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia UniversityTaub Institute for Research On Alzheimer’s Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia UniversityTaub Institute for Research On Alzheimer’s Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia UniversityTaub Institute for Research On Alzheimer’s Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia UniversityTaub Institute for Research On Alzheimer’s Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia UniversityTaub Institute for Research On Alzheimer’s Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia UniversityTaub Institute for Research On Alzheimer’s Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia UniversityAbstract Inflammation plays a major role in cognitive aging. Most studies on peripheral inflammation and cognitive aging focused on selected major inflammatory biomarkers. However, inflammatory markers are regulated and influenced by each other, and it is therefore important to consider a more comprehensive panel of markers to better capture diverse immune pathways and characterize the overall inflammatory profile of individuals. We explored 23 circulating inflammatory biomarkers using data from 1,743 participants without dementia (≥ 65 years-old) from the community-based, multiethnic Washington Heights Inwood Columbia Aging Project. Using principal component analysis (PCA), we developed six inflammatory profiles (PC-1 to PC-6) based on these 23 biomarkers and tested the association of resulting inflammatory profile with cognitive decline, over up to 12 years of follow-up. PC-1 described a pro-inflammatory profile characterized by high positive loadings for pro-inflammatory biomarkers. A higher PC-1 score was associated with lower baseline cognitive performances. No association of this profile with cognitive decline was observed in longitudinal analysis. However, PC-5 characterized by high PDGF-AA and RANTES was associated with a faster cognitive decline. Among older adults, a circulating pro-inflammatory immune profile is associated with lower baseline cognitive performance, and some specific pro-inflammatory cytokines might be associated with faster cognitive decline.https://doi.org/10.1038/s41598-025-86309-zPeripheral inflammationCognitionCognitive declineCohortEpidemiology |
| spellingShingle | Aline Thomas Jing Guo Dolly Reyes-Dumeyer Danurys Sanchez Nikolaos Scarmeas Jennifer J. Manly Adam M. Brickman Rafael A. Lantigua Richard Mayeux Yian Gu Inflammatory biomarkers profiles and cognition among older adults Scientific Reports Peripheral inflammation Cognition Cognitive decline Cohort Epidemiology |
| title | Inflammatory biomarkers profiles and cognition among older adults |
| title_full | Inflammatory biomarkers profiles and cognition among older adults |
| title_fullStr | Inflammatory biomarkers profiles and cognition among older adults |
| title_full_unstemmed | Inflammatory biomarkers profiles and cognition among older adults |
| title_short | Inflammatory biomarkers profiles and cognition among older adults |
| title_sort | inflammatory biomarkers profiles and cognition among older adults |
| topic | Peripheral inflammation Cognition Cognitive decline Cohort Epidemiology |
| url | https://doi.org/10.1038/s41598-025-86309-z |
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