Hepatitis B, С, D prevalence among childbearing age women in Ha Giang province, Vietnam: a cross-sectional study
Background/Aim: The high mortality rates from liver cancer caused by hepatitis B virus (HBV) and hepatitis C virus (HCV) occur in Asia and Africa. In HBV endemic countries (HBsAg prevalence > 8%), mother-to-child transmission of HBV plays an important role in the epidemiology of the infection. Al...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | International Journal of Infectious Diseases |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971224006866 |
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| author | Evgeniia Lichnaia Nga Bui Thi Thanh Olga Petrova Daria Starkova Nhai Tran Thi Cuong Vo Viet Alexander Dmitriev Olga Kalinina |
| author_facet | Evgeniia Lichnaia Nga Bui Thi Thanh Olga Petrova Daria Starkova Nhai Tran Thi Cuong Vo Viet Alexander Dmitriev Olga Kalinina |
| author_sort | Evgeniia Lichnaia |
| collection | DOAJ |
| description | Background/Aim: The high mortality rates from liver cancer caused by hepatitis B virus (HBV) and hepatitis C virus (HCV) occur in Asia and Africa. In HBV endemic countries (HBsAg prevalence > 8%), mother-to-child transmission of HBV plays an important role in the epidemiology of the infection. Almost 33% of all infected children become infected in pregnancy and 50% become infected during childbirth. The goal of this study was to evaluate the prevalence of HBV, HCV, HDV in childbearing age women in the rural province Ha Giang. Material and Methods: A total of 661 women of 18-49 years old (mean age 34.9±8.5) belonging to different ethnic minorities were enrolled in the study conducted in several district of the Ha Giang province in 2019-2023. Of 661 women, 51.1% (338/661) were Hmong ethnic, 22.6% (149/661) were Tay ethnic, 13.0% (86/661) were Dao ethnic, and 13.3% (88/661) were belonged to other small minorities. The specific serological markers of HBV, HCV, HDV were detected by ELISA using commercial kits (RPC Diagnostic Systems, Russia). Results: Totally, the prevalence of HBsAg, anti-HBc and anti-HBs was 10.7% (71/661; 95%CI 8.6-13.3), 55.2% (365/661; 95%CI 51.4-59.0), 36.6% (242/661; 95%CI 33.0-40.4), respectively. DNA HBV was detected in 9.4% (62/661; 95%CI 7.4-11.8). The prevalence of HCV antibodies was 0.8% (5/661; 95%CI 0.3-1.8). HCV RNA was detected in 0.5% (3/661; 95%CI 0.2-1.3). No specific serological markers to HDV were found in all studied samples. Among the participants, only 38.9% (255/661; 95% CI 34.9-42.3) women were negative for markers to viral hepatitis B, C and D. Conclusion: The obtained results indicate a high level of HBV prevalence among childbearing age women living in the northern rural province Ha Giang in Vietnam. Screening program of women of childbearing age in endemic counties of Asia and Africa is still very important to reveal woman with high risk of perinatal transmission of viral hepatitis B, C and D at the pregravid period to prevent perinatal transmission to child. |
| format | Article |
| id | doaj-art-641c37a9c8ee467aa70fade9d4c6f403 |
| institution | OA Journals |
| issn | 1201-9712 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
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| series | International Journal of Infectious Diseases |
| spelling | doaj-art-641c37a9c8ee467aa70fade9d4c6f4032025-08-20T02:10:57ZengElsevierInternational Journal of Infectious Diseases1201-97122025-03-0115210761110.1016/j.ijid.2024.107611Hepatitis B, С, D prevalence among childbearing age women in Ha Giang province, Vietnam: a cross-sectional studyEvgeniia Lichnaia0Nga Bui Thi Thanh1Olga Petrova2Daria Starkova3Nhai Tran Thi4Cuong Vo Viet5Alexander Dmitriev6Olga Kalinina7Saint-Petersburg Pasteur InstituteJoint Russian-Vietnamese Tropical Science and Technology CenterSaint-Petersburg Pasteur InstituteSaint-Petersburg Pasteur InstituteJoint Russian-Vietnamese Tropical Science and Technology CenterJoint Russian-Vietnamese Tropical Science and Technology CenterSaint Petersburg State Institute of TechnologySaint-Petersburg Pasteur InstituteBackground/Aim: The high mortality rates from liver cancer caused by hepatitis B virus (HBV) and hepatitis C virus (HCV) occur in Asia and Africa. In HBV endemic countries (HBsAg prevalence > 8%), mother-to-child transmission of HBV plays an important role in the epidemiology of the infection. Almost 33% of all infected children become infected in pregnancy and 50% become infected during childbirth. The goal of this study was to evaluate the prevalence of HBV, HCV, HDV in childbearing age women in the rural province Ha Giang. Material and Methods: A total of 661 women of 18-49 years old (mean age 34.9±8.5) belonging to different ethnic minorities were enrolled in the study conducted in several district of the Ha Giang province in 2019-2023. Of 661 women, 51.1% (338/661) were Hmong ethnic, 22.6% (149/661) were Tay ethnic, 13.0% (86/661) were Dao ethnic, and 13.3% (88/661) were belonged to other small minorities. The specific serological markers of HBV, HCV, HDV were detected by ELISA using commercial kits (RPC Diagnostic Systems, Russia). Results: Totally, the prevalence of HBsAg, anti-HBc and anti-HBs was 10.7% (71/661; 95%CI 8.6-13.3), 55.2% (365/661; 95%CI 51.4-59.0), 36.6% (242/661; 95%CI 33.0-40.4), respectively. DNA HBV was detected in 9.4% (62/661; 95%CI 7.4-11.8). The prevalence of HCV antibodies was 0.8% (5/661; 95%CI 0.3-1.8). HCV RNA was detected in 0.5% (3/661; 95%CI 0.2-1.3). No specific serological markers to HDV were found in all studied samples. Among the participants, only 38.9% (255/661; 95% CI 34.9-42.3) women were negative for markers to viral hepatitis B, C and D. Conclusion: The obtained results indicate a high level of HBV prevalence among childbearing age women living in the northern rural province Ha Giang in Vietnam. Screening program of women of childbearing age in endemic counties of Asia and Africa is still very important to reveal woman with high risk of perinatal transmission of viral hepatitis B, C and D at the pregravid period to prevent perinatal transmission to child.http://www.sciencedirect.com/science/article/pii/S1201971224006866 |
| spellingShingle | Evgeniia Lichnaia Nga Bui Thi Thanh Olga Petrova Daria Starkova Nhai Tran Thi Cuong Vo Viet Alexander Dmitriev Olga Kalinina Hepatitis B, С, D prevalence among childbearing age women in Ha Giang province, Vietnam: a cross-sectional study International Journal of Infectious Diseases |
| title | Hepatitis B, С, D prevalence among childbearing age women in Ha Giang province, Vietnam: a cross-sectional study |
| title_full | Hepatitis B, С, D prevalence among childbearing age women in Ha Giang province, Vietnam: a cross-sectional study |
| title_fullStr | Hepatitis B, С, D prevalence among childbearing age women in Ha Giang province, Vietnam: a cross-sectional study |
| title_full_unstemmed | Hepatitis B, С, D prevalence among childbearing age women in Ha Giang province, Vietnam: a cross-sectional study |
| title_short | Hepatitis B, С, D prevalence among childbearing age women in Ha Giang province, Vietnam: a cross-sectional study |
| title_sort | hepatitis b с d prevalence among childbearing age women in ha giang province vietnam a cross sectional study |
| url | http://www.sciencedirect.com/science/article/pii/S1201971224006866 |
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