Representing unsegmented vessels using available vascular data for bioheat transfer simulation
IntroductionA primary challenge with voxel domains generated from imaging data is associated with voxel resolution. Due to the dimensional scale of blood vessels, not all vessels are captured in a given voxel resolution, leading to discontinuous blood vessels in the segmentation. Pre-capillary vesse...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Thermal Engineering |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fther.2025.1536410/full |
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| author | Rohan Amare Amir A. Bahadori Amir A. Bahadori Steven Eckels Steven Eckels |
| author_facet | Rohan Amare Amir A. Bahadori Amir A. Bahadori Steven Eckels Steven Eckels |
| author_sort | Rohan Amare |
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| description | IntroductionA primary challenge with voxel domains generated from imaging data is associated with voxel resolution. Due to the dimensional scale of blood vessels, not all vessels are captured in a given voxel resolution, leading to discontinuous blood vessels in the segmentation. Pre-capillary vessels like arterioles, which provide the highest resistance to blood flow, are often modeled with tissue as a porous domain due to resolution limitations. This results in a loss of information that could have been modeled if these vessels were segmented and modeled distinctly from the capillary bed.MethodsThis paper focuses on developing mathematical equations to calculate the flow resistance of unsegmented vasculature with reference to flow resistance of available segmented vascular data. A 3D vascular domain of 32 terminal vessels and five generations of bifurcation is simulated. Each generation is successively removed and substituted with the new flow resistance equations to analyze the error in heat transfer due to a lack of segmentation data.ResultsThe effect of using mathematical equations of flow resistance on bioheat transfer is analyzed. Two methods are proposed and demonstrated to show considerable error reduction in bioheat transfer.DiscussionVery high image resolution, which could allow modeling of pre-capillary vessels, increases the computational cost of the entire simulation domain. Instead, a mathematical representation of the pressure drop induced in these unsegmented blood vessels is used. The proposed methods show potential in reducing the error resulting from the lack of segmentation data, improving the accuracy of bioheat transfer simulations. |
| format | Article |
| id | doaj-art-640d99ee60ff40e0a4e3d5360eea8c8a |
| institution | Kabale University |
| issn | 2813-0456 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Thermal Engineering |
| spelling | doaj-art-640d99ee60ff40e0a4e3d5360eea8c8a2025-02-06T07:09:25ZengFrontiers Media S.A.Frontiers in Thermal Engineering2813-04562025-02-01510.3389/fther.2025.15364101536410Representing unsegmented vessels using available vascular data for bioheat transfer simulationRohan Amare0Amir A. Bahadori1Amir A. Bahadori2Steven Eckels3Steven Eckels4Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, United StatesRadiological Engineering Analysis Laboratory, Kansas State University, Manhattan, KS, United StatesAlan Levin Department of Mechanical and Nuclear Engineering, Kansas State University, Manhattan, KS, United StatesAlan Levin Department of Mechanical and Nuclear Engineering, Kansas State University, Manhattan, KS, United StatesInstitute for Environmental Research, Kansas State University, Manhattan, KS, United StatesIntroductionA primary challenge with voxel domains generated from imaging data is associated with voxel resolution. Due to the dimensional scale of blood vessels, not all vessels are captured in a given voxel resolution, leading to discontinuous blood vessels in the segmentation. Pre-capillary vessels like arterioles, which provide the highest resistance to blood flow, are often modeled with tissue as a porous domain due to resolution limitations. This results in a loss of information that could have been modeled if these vessels were segmented and modeled distinctly from the capillary bed.MethodsThis paper focuses on developing mathematical equations to calculate the flow resistance of unsegmented vasculature with reference to flow resistance of available segmented vascular data. A 3D vascular domain of 32 terminal vessels and five generations of bifurcation is simulated. Each generation is successively removed and substituted with the new flow resistance equations to analyze the error in heat transfer due to a lack of segmentation data.ResultsThe effect of using mathematical equations of flow resistance on bioheat transfer is analyzed. Two methods are proposed and demonstrated to show considerable error reduction in bioheat transfer.DiscussionVery high image resolution, which could allow modeling of pre-capillary vessels, increases the computational cost of the entire simulation domain. Instead, a mathematical representation of the pressure drop induced in these unsegmented blood vessels is used. The proposed methods show potential in reducing the error resulting from the lack of segmentation data, improving the accuracy of bioheat transfer simulations.https://www.frontiersin.org/articles/10.3389/fther.2025.1536410/fullcomputational biophysicscomputational modelingbioheat equationmultiscale modelingbioheat transfer |
| spellingShingle | Rohan Amare Amir A. Bahadori Amir A. Bahadori Steven Eckels Steven Eckels Representing unsegmented vessels using available vascular data for bioheat transfer simulation Frontiers in Thermal Engineering computational biophysics computational modeling bioheat equation multiscale modeling bioheat transfer |
| title | Representing unsegmented vessels using available vascular data for bioheat transfer simulation |
| title_full | Representing unsegmented vessels using available vascular data for bioheat transfer simulation |
| title_fullStr | Representing unsegmented vessels using available vascular data for bioheat transfer simulation |
| title_full_unstemmed | Representing unsegmented vessels using available vascular data for bioheat transfer simulation |
| title_short | Representing unsegmented vessels using available vascular data for bioheat transfer simulation |
| title_sort | representing unsegmented vessels using available vascular data for bioheat transfer simulation |
| topic | computational biophysics computational modeling bioheat equation multiscale modeling bioheat transfer |
| url | https://www.frontiersin.org/articles/10.3389/fther.2025.1536410/full |
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