Elevated Neutrophil Lymphocyte Ratio in Recurrent Optic Neuritis
Purpose. To demonstrate the relation between optic neuritis (ON) and systemic inflammation markers as neutrophil lymphocyte ratio (N/L ratio), platelet count, mean platelet volume (MPV), and red cell distribution width (RDW) and furthermore to evaluate the utilization of these markers to predict the...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2015/758687 |
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| author | Hande Guclu Sadık Altan Ozal Vuslat Pelitli Gurlu Ramazan Birgul |
| author_facet | Hande Guclu Sadık Altan Ozal Vuslat Pelitli Gurlu Ramazan Birgul |
| author_sort | Hande Guclu |
| collection | DOAJ |
| description | Purpose. To demonstrate the relation between optic neuritis (ON) and systemic inflammation markers as neutrophil lymphocyte ratio (N/L ratio), platelet count, mean platelet volume (MPV), and red cell distribution width (RDW) and furthermore to evaluate the utilization of these markers to predict the frequency of the ON episodes. Methods. Forty-two patients with acute ON and forty healthy subjects were enrolled into the study. The medical records were reviewed for age, sex, hemoglobin (Hb), Haematocrit (Htc), RDW, platelet count, MPV, white blood cell count (WBC), neutrophil and lymphocyte count, and neutrophil lymphocyte ratio (N/L ratio). Results. The mean N/L ratio, platelet counts, and RDW were significantly higher in ON group (p=0.000, p=0.048, and p=0.002). There was a significant relation between N/L ratio and number of episodes (r=0.492, p=0.001). There was a statistically significant difference for MPV between one episode group and recurrent ON group (p=0.035). Conclusions. Simple and inexpensive laboratory methods could help us show systemic inflammation and monitor ON patients. Higher N/L ratio can be a useful marker for predicting recurrent attacks. |
| format | Article |
| id | doaj-art-63fe4028d09a41909870e92f5fdfca27 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-63fe4028d09a41909870e92f5fdfca272025-02-03T01:10:21ZengWileyJournal of Ophthalmology2090-004X2090-00582015-01-01201510.1155/2015/758687758687Elevated Neutrophil Lymphocyte Ratio in Recurrent Optic NeuritisHande Guclu0Sadık Altan Ozal1Vuslat Pelitli Gurlu2Ramazan Birgul3Department of Opthalmology, Faculty of Medicine, Trakya University, 22030 Edirne, TurkeyDepartment of Opthalmology, Faculty of Medicine, Trakya University, 22030 Edirne, TurkeyDepartment of Opthalmology, Faculty of Medicine, Trakya University, 22030 Edirne, TurkeyDepartment of Opthalmology, Faculty of Medicine, Trakya University, 22030 Edirne, TurkeyPurpose. To demonstrate the relation between optic neuritis (ON) and systemic inflammation markers as neutrophil lymphocyte ratio (N/L ratio), platelet count, mean platelet volume (MPV), and red cell distribution width (RDW) and furthermore to evaluate the utilization of these markers to predict the frequency of the ON episodes. Methods. Forty-two patients with acute ON and forty healthy subjects were enrolled into the study. The medical records were reviewed for age, sex, hemoglobin (Hb), Haematocrit (Htc), RDW, platelet count, MPV, white blood cell count (WBC), neutrophil and lymphocyte count, and neutrophil lymphocyte ratio (N/L ratio). Results. The mean N/L ratio, platelet counts, and RDW were significantly higher in ON group (p=0.000, p=0.048, and p=0.002). There was a significant relation between N/L ratio and number of episodes (r=0.492, p=0.001). There was a statistically significant difference for MPV between one episode group and recurrent ON group (p=0.035). Conclusions. Simple and inexpensive laboratory methods could help us show systemic inflammation and monitor ON patients. Higher N/L ratio can be a useful marker for predicting recurrent attacks.http://dx.doi.org/10.1155/2015/758687 |
| spellingShingle | Hande Guclu Sadık Altan Ozal Vuslat Pelitli Gurlu Ramazan Birgul Elevated Neutrophil Lymphocyte Ratio in Recurrent Optic Neuritis Journal of Ophthalmology |
| title | Elevated Neutrophil Lymphocyte Ratio in Recurrent Optic Neuritis |
| title_full | Elevated Neutrophil Lymphocyte Ratio in Recurrent Optic Neuritis |
| title_fullStr | Elevated Neutrophil Lymphocyte Ratio in Recurrent Optic Neuritis |
| title_full_unstemmed | Elevated Neutrophil Lymphocyte Ratio in Recurrent Optic Neuritis |
| title_short | Elevated Neutrophil Lymphocyte Ratio in Recurrent Optic Neuritis |
| title_sort | elevated neutrophil lymphocyte ratio in recurrent optic neuritis |
| url | http://dx.doi.org/10.1155/2015/758687 |
| work_keys_str_mv | AT handeguclu elevatedneutrophillymphocyteratioinrecurrentopticneuritis AT sadıkaltanozal elevatedneutrophillymphocyteratioinrecurrentopticneuritis AT vuslatpelitligurlu elevatedneutrophillymphocyteratioinrecurrentopticneuritis AT ramazanbirgul elevatedneutrophillymphocyteratioinrecurrentopticneuritis |