Differences in Clinical and Imaging Features between Asymptomatic and Symptomatic COVID-19 Patients
Objectives. The clinical and imaging features of asymptomatic carriers of severe acute respiratory syndrome coronavirus 2 and symptomatic COVID-19 patients. Methods. The clinical and chest computed tomography imaging data of 47 asymptomatic carriers and 36 symptomatic COVID-19 patients were derived....
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | International Journal of Clinical Practice |
| Online Access: | http://dx.doi.org/10.1155/2022/4763953 |
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| author | Xi Ma Zhi-Yan Lu Yan-Juan Qu Li-Hong Xing Yu Zhang Yi-Bo Lu Li Dong Hong-Jun Li Li Li Xiao-Ping Yin Chuan-Jun Xu |
| author_facet | Xi Ma Zhi-Yan Lu Yan-Juan Qu Li-Hong Xing Yu Zhang Yi-Bo Lu Li Dong Hong-Jun Li Li Li Xiao-Ping Yin Chuan-Jun Xu |
| author_sort | Xi Ma |
| collection | DOAJ |
| description | Objectives. The clinical and imaging features of asymptomatic carriers of severe acute respiratory syndrome coronavirus 2 and symptomatic COVID-19 patients. Methods. The clinical and chest computed tomography imaging data of 47 asymptomatic carriers and 36 symptomatic COVID-19 patients were derived. All patients underwent 4–6 CT scans over a period of 2–5 days. Results. The bulk of asymptomatic carriers who developed symptoms and most of the COVID-19 patients were older than 18 years of age with a decreased lymphocyte count, abnormal hepatic and renal function, and increased D-dimer and C-reactive protein. In the early stage, the pulmonary lesion involved mostly 1–2 lobes at the peripheral area in asymptomatic carriers but more than three lobes at both the central and peripheral areas in COVID-19 patients. In the progression stage, the lesion of asymptomatic carriers extended from the peripheral to the central area, and no significant difference was found in the lesion range compared with the symptomatic control group. In early improvement stage, the lesion was rapidly absorbed, and lesions were located primarily at the peripheral area in asymptomatic carriers; contrastingly, lesions were primarily located at both the central and peripheral areas in symptomatic patients. Asymptomatic carriers reflected a significantly shorter duration from disease onset to peak progression stage compared with the symptomatic. Conclusions. Asymptomatic carriers are a potential source of transmission and may become symptomatic COVID-19 patients despite indicating less severe pulmonary damage, earlier improvement, and better prognosis. Early isolation and intervention can eliminate such carriers as potential sources of transmission and improve their prognosis. |
| format | Article |
| id | doaj-art-63fb0f1b93aa46e383fb009588c9a15e |
| institution | Kabale University |
| issn | 1742-1241 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Clinical Practice |
| spelling | doaj-art-63fb0f1b93aa46e383fb009588c9a15e2025-02-03T05:57:59ZengWileyInternational Journal of Clinical Practice1742-12412022-01-01202210.1155/2022/4763953Differences in Clinical and Imaging Features between Asymptomatic and Symptomatic COVID-19 PatientsXi Ma0Zhi-Yan Lu1Yan-Juan Qu2Li-Hong Xing3Yu Zhang4Yi-Bo Lu5Li Dong6Hong-Jun Li7Li Li8Xiao-Ping Yin9Chuan-Jun Xu10CT/MRI RoomDepartment of RadiologyDepartment of RadiologyCT/MRI RoomCT/MRI RoomDepartment of RadiologyDepartment of RadiologyDepartment of RadiologyDepartment of RadiologyCT/MRI RoomDepartment of RadiologyObjectives. The clinical and imaging features of asymptomatic carriers of severe acute respiratory syndrome coronavirus 2 and symptomatic COVID-19 patients. Methods. The clinical and chest computed tomography imaging data of 47 asymptomatic carriers and 36 symptomatic COVID-19 patients were derived. All patients underwent 4–6 CT scans over a period of 2–5 days. Results. The bulk of asymptomatic carriers who developed symptoms and most of the COVID-19 patients were older than 18 years of age with a decreased lymphocyte count, abnormal hepatic and renal function, and increased D-dimer and C-reactive protein. In the early stage, the pulmonary lesion involved mostly 1–2 lobes at the peripheral area in asymptomatic carriers but more than three lobes at both the central and peripheral areas in COVID-19 patients. In the progression stage, the lesion of asymptomatic carriers extended from the peripheral to the central area, and no significant difference was found in the lesion range compared with the symptomatic control group. In early improvement stage, the lesion was rapidly absorbed, and lesions were located primarily at the peripheral area in asymptomatic carriers; contrastingly, lesions were primarily located at both the central and peripheral areas in symptomatic patients. Asymptomatic carriers reflected a significantly shorter duration from disease onset to peak progression stage compared with the symptomatic. Conclusions. Asymptomatic carriers are a potential source of transmission and may become symptomatic COVID-19 patients despite indicating less severe pulmonary damage, earlier improvement, and better prognosis. Early isolation and intervention can eliminate such carriers as potential sources of transmission and improve their prognosis.http://dx.doi.org/10.1155/2022/4763953 |
| spellingShingle | Xi Ma Zhi-Yan Lu Yan-Juan Qu Li-Hong Xing Yu Zhang Yi-Bo Lu Li Dong Hong-Jun Li Li Li Xiao-Ping Yin Chuan-Jun Xu Differences in Clinical and Imaging Features between Asymptomatic and Symptomatic COVID-19 Patients International Journal of Clinical Practice |
| title | Differences in Clinical and Imaging Features between Asymptomatic and Symptomatic COVID-19 Patients |
| title_full | Differences in Clinical and Imaging Features between Asymptomatic and Symptomatic COVID-19 Patients |
| title_fullStr | Differences in Clinical and Imaging Features between Asymptomatic and Symptomatic COVID-19 Patients |
| title_full_unstemmed | Differences in Clinical and Imaging Features between Asymptomatic and Symptomatic COVID-19 Patients |
| title_short | Differences in Clinical and Imaging Features between Asymptomatic and Symptomatic COVID-19 Patients |
| title_sort | differences in clinical and imaging features between asymptomatic and symptomatic covid 19 patients |
| url | http://dx.doi.org/10.1155/2022/4763953 |
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