The Role of Autophagy in the Pathogenesis of Diabetic Nephropathy
Diabetic nephropathy is a leading cause of end-stage renal disease worldwide. The multipronged drug approach targeting blood pressure and serum levels of glucose, insulin, and lipids fails to fully prevent the onset and progression of diabetic nephropathy. Therefore, a new therapeutic target to comb...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2013/193757 |
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| _version_ | 1832550356757774336 |
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| author | Kosuke Yamahara Mako Yasuda Shinji Kume Daisuke Koya Hiroshi Maegawa Takashi Uzu |
| author_facet | Kosuke Yamahara Mako Yasuda Shinji Kume Daisuke Koya Hiroshi Maegawa Takashi Uzu |
| author_sort | Kosuke Yamahara |
| collection | DOAJ |
| description | Diabetic nephropathy is a leading cause of end-stage renal disease worldwide. The multipronged drug approach targeting blood pressure and serum levels of glucose, insulin, and lipids fails to fully prevent the onset and progression of diabetic nephropathy. Therefore, a new therapeutic target to combat diabetic nephropathy is required. Autophagy is a catabolic process that degrades damaged proteins and organelles in mammalian cells and plays a critical role in maintaining cellular homeostasis. The accumulation of proteins and organelles damaged by hyperglycemia and other diabetes-related metabolic changes is highly associated with the development of diabetic nephropathy. Recent studies have suggested that autophagy activity is altered in both podocytes and proximal tubular cells under diabetic conditions. Autophagy activity is regulated by both nutrient state and intracellular stresses. Under diabetic conditions, an altered nutritional state due to nutrient excess may interfere with the autophagic response stimulated by intracellular stresses, leading to exacerbation of organelle dysfunction and diabetic nephropathy. In this review, we discuss new findings showing the relationships between autophagy and diabetic nephropathy and suggest the therapeutic potential of autophagy in diabetic nephropathy. |
| format | Article |
| id | doaj-art-63eac3bfdaa941728f863882e83e4f68 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-63eac3bfdaa941728f863882e83e4f682025-02-03T06:07:02ZengWileyJournal of Diabetes Research2314-67452314-67532013-01-01201310.1155/2013/193757193757The Role of Autophagy in the Pathogenesis of Diabetic NephropathyKosuke Yamahara0Mako Yasuda1Shinji Kume2Daisuke Koya3Hiroshi Maegawa4Takashi Uzu5Department of Medicine, Shiga University of Medical Science, Tsukinowa-Cho, Seta, Otsu, Shiga 520-2192, JapanDepartment of Medicine, Shiga University of Medical Science, Tsukinowa-Cho, Seta, Otsu, Shiga 520-2192, JapanDepartment of Medicine, Shiga University of Medical Science, Tsukinowa-Cho, Seta, Otsu, Shiga 520-2192, JapanDiabetes & Endocrinology, Kanazawa Medical University, Daigaku 1-1, Kahoku-Gun, Uchinada, Ishikawa 920-0293, JapanDepartment of Medicine, Shiga University of Medical Science, Tsukinowa-Cho, Seta, Otsu, Shiga 520-2192, JapanDepartment of Medicine, Shiga University of Medical Science, Tsukinowa-Cho, Seta, Otsu, Shiga 520-2192, JapanDiabetic nephropathy is a leading cause of end-stage renal disease worldwide. The multipronged drug approach targeting blood pressure and serum levels of glucose, insulin, and lipids fails to fully prevent the onset and progression of diabetic nephropathy. Therefore, a new therapeutic target to combat diabetic nephropathy is required. Autophagy is a catabolic process that degrades damaged proteins and organelles in mammalian cells and plays a critical role in maintaining cellular homeostasis. The accumulation of proteins and organelles damaged by hyperglycemia and other diabetes-related metabolic changes is highly associated with the development of diabetic nephropathy. Recent studies have suggested that autophagy activity is altered in both podocytes and proximal tubular cells under diabetic conditions. Autophagy activity is regulated by both nutrient state and intracellular stresses. Under diabetic conditions, an altered nutritional state due to nutrient excess may interfere with the autophagic response stimulated by intracellular stresses, leading to exacerbation of organelle dysfunction and diabetic nephropathy. In this review, we discuss new findings showing the relationships between autophagy and diabetic nephropathy and suggest the therapeutic potential of autophagy in diabetic nephropathy.http://dx.doi.org/10.1155/2013/193757 |
| spellingShingle | Kosuke Yamahara Mako Yasuda Shinji Kume Daisuke Koya Hiroshi Maegawa Takashi Uzu The Role of Autophagy in the Pathogenesis of Diabetic Nephropathy Journal of Diabetes Research |
| title | The Role of Autophagy in the Pathogenesis of Diabetic Nephropathy |
| title_full | The Role of Autophagy in the Pathogenesis of Diabetic Nephropathy |
| title_fullStr | The Role of Autophagy in the Pathogenesis of Diabetic Nephropathy |
| title_full_unstemmed | The Role of Autophagy in the Pathogenesis of Diabetic Nephropathy |
| title_short | The Role of Autophagy in the Pathogenesis of Diabetic Nephropathy |
| title_sort | role of autophagy in the pathogenesis of diabetic nephropathy |
| url | http://dx.doi.org/10.1155/2013/193757 |
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