IL-17 and IL-22 in Cerebrospinal Fluid and Plasma Are Elevated in Guillain-Barré Syndrome
Guillain-Barré syndrome (GBS) is an acute autoimmune-mediated inflammatory demyelinating disease that causes rapidly progressing paralysis and occasionally respiratory failure. We hypothesized that interleukin (IL)-17 and IL-22 are elevated in GBS and participate in the autoimmune inflammatory respo...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2012/260473 |
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| author | Shujuan Li Ming Yu Haifeng Li Hongliang Zhang Yanfang Jiang |
| author_facet | Shujuan Li Ming Yu Haifeng Li Hongliang Zhang Yanfang Jiang |
| author_sort | Shujuan Li |
| collection | DOAJ |
| description | Guillain-Barré syndrome (GBS) is an acute autoimmune-mediated inflammatory demyelinating disease that causes rapidly progressing paralysis and occasionally respiratory failure. We hypothesized that interleukin (IL)-17 and IL-22 are elevated in GBS and participate in the autoimmune inflammatory response of GBS. We used sandwich enzyme-linked immunosorbent assay (ELISA) to measure the IL-17 and IL-22 levels in the CSF, and plasma from 22 GBS patients at the acute phase and 18 healthy controls (HC). The results show that CSF and plasma levels of IL-17 and IL-22 are elevated in GBS patients compared with HC. IL-17 and IL-22 levels in CSF, respectively, are correlated with GBS disability scale scores (GDSs). Meanwhile, IL-17 and IL-22 levels in CSF, IL-22 in CSF, and plasma of GBS patients have positive correlation, respectively. The increased levels of IL-17 and IL-22 in CSF may be explained by the disruption of blood-brain barrier (BBB) and peripheral nervous system (PNS) local inflammation in GBS. Meanwhile, the elevated levels of these two cytokines in plasma suggest the activation of Th17 and Th22 cells in the systemic immune response of GBS. Our data provide preliminary evidence that GBS is associated with high levels of IL-17 and IL-22 in CSF and plasma. These cytokines display pathogenic potential and may serve as useful biomarkers for GBS. |
| format | Article |
| id | doaj-art-63e25b121d9e489a98292f65d051b61d |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-63e25b121d9e489a98292f65d051b61d2025-02-03T05:43:52ZengWileyMediators of Inflammation0962-93511466-18612012-01-01201210.1155/2012/260473260473IL-17 and IL-22 in Cerebrospinal Fluid and Plasma Are Elevated in Guillain-Barré SyndromeShujuan Li0Ming Yu1Haifeng Li2Hongliang Zhang3Yanfang Jiang4Department of Neurology, The First Hospital, Jilin University, Jilin Province, Changchun 130021, ChinaDepartment of Neurology, The Affiliated Hospital of Jiangsu University, Jiangsu Province, Zhenjiang 212001, ChinaDepartment of Neurology, The Affiliated Hospital of Medical College, Qingdao University, Shandong Province, Qingdao 266003, ChinaDepartment of Neurology, The First Hospital, Jilin University, Jilin Province, Changchun 130021, ChinaDepartment of Central Laboratory, The Second Part of the First Hospital, Jilin University, Jilin Province, Changchun 130032, ChinaGuillain-Barré syndrome (GBS) is an acute autoimmune-mediated inflammatory demyelinating disease that causes rapidly progressing paralysis and occasionally respiratory failure. We hypothesized that interleukin (IL)-17 and IL-22 are elevated in GBS and participate in the autoimmune inflammatory response of GBS. We used sandwich enzyme-linked immunosorbent assay (ELISA) to measure the IL-17 and IL-22 levels in the CSF, and plasma from 22 GBS patients at the acute phase and 18 healthy controls (HC). The results show that CSF and plasma levels of IL-17 and IL-22 are elevated in GBS patients compared with HC. IL-17 and IL-22 levels in CSF, respectively, are correlated with GBS disability scale scores (GDSs). Meanwhile, IL-17 and IL-22 levels in CSF, IL-22 in CSF, and plasma of GBS patients have positive correlation, respectively. The increased levels of IL-17 and IL-22 in CSF may be explained by the disruption of blood-brain barrier (BBB) and peripheral nervous system (PNS) local inflammation in GBS. Meanwhile, the elevated levels of these two cytokines in plasma suggest the activation of Th17 and Th22 cells in the systemic immune response of GBS. Our data provide preliminary evidence that GBS is associated with high levels of IL-17 and IL-22 in CSF and plasma. These cytokines display pathogenic potential and may serve as useful biomarkers for GBS.http://dx.doi.org/10.1155/2012/260473 |
| spellingShingle | Shujuan Li Ming Yu Haifeng Li Hongliang Zhang Yanfang Jiang IL-17 and IL-22 in Cerebrospinal Fluid and Plasma Are Elevated in Guillain-Barré Syndrome Mediators of Inflammation |
| title | IL-17 and IL-22 in Cerebrospinal Fluid and Plasma Are Elevated in Guillain-Barré Syndrome |
| title_full | IL-17 and IL-22 in Cerebrospinal Fluid and Plasma Are Elevated in Guillain-Barré Syndrome |
| title_fullStr | IL-17 and IL-22 in Cerebrospinal Fluid and Plasma Are Elevated in Guillain-Barré Syndrome |
| title_full_unstemmed | IL-17 and IL-22 in Cerebrospinal Fluid and Plasma Are Elevated in Guillain-Barré Syndrome |
| title_short | IL-17 and IL-22 in Cerebrospinal Fluid and Plasma Are Elevated in Guillain-Barré Syndrome |
| title_sort | il 17 and il 22 in cerebrospinal fluid and plasma are elevated in guillain barre syndrome |
| url | http://dx.doi.org/10.1155/2012/260473 |
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