Predictive factors associated with short‐term mortality in cats with feline infectious peritonitis treated with remdesivir or GS‐441524 or both

Abstract Background Although most cats with feline infectious peritonitis (FIP) respond to treatment with remdesivir or GS‐441524 or both with uneventful clinical courses, some die despite treatment. Objective Identify predictive factors associated with short‐term mortality in cats with FIP treated...

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Main Authors: Sho Goto, Tsuyoshi Kamiyoshi, Ryota Iwasaki
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Journal of Veterinary Internal Medicine
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Online Access:https://doi.org/10.1111/jvim.17249
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author Sho Goto
Tsuyoshi Kamiyoshi
Ryota Iwasaki
author_facet Sho Goto
Tsuyoshi Kamiyoshi
Ryota Iwasaki
author_sort Sho Goto
collection DOAJ
description Abstract Background Although most cats with feline infectious peritonitis (FIP) respond to treatment with remdesivir or GS‐441524 or both with uneventful clinical courses, some die despite treatment. Objective Identify predictive factors associated with short‐term mortality in cats with FIP treated with IV remdesivir or PO GS‐441524 or both. Animals A total of 108 client‐owned cats with FIP. Methods Retrospective multicenter study using data collected from medical records. Factors associated with short‐term mortality, defined as death within 84 days, were identified. Univariate analysis a t‐test, Mann‐Whitney U test, or Fisher's exact test and multivariate logistic regression were performed to assess patient characteristics and clinicopathological variables between survivors and nonsurvivors. Results The short‐term mortality rate was 12.0% (95% confidence interval [CI], 6.6%‐19.7%). Univariate analysis identified plasma lactate dehydrogenase activity (LDH; P < .001) and bilirubin concentration (P = .001) as being significantly increased in nonsurvivors, whereas concentrations of albumin (P = .003), total protein (P = .03), sodium (P = .005), and potassium (P = .005) were significantly lower. Additionally, nonsurvivors were significantly less likely to be febrile (≥39.4°C; P = .006). Of these variables, only plasma LDH activity ≥323 U/L, a cut‐point determined by receiver operating characteristic curve analysis, was significantly associated with short‐term mortality by multivariate analysis (odds ratio, 15.30; 95% CI, 1.18‐198.00; P = .04). Conclusion Increased plasma LDH activity might be useful for predicting short‐term mortality, guiding monitoring, and establishing prognosis in cats with FIP.
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spelling doaj-art-63ddf43ed8cc47d5a280fcebfe0f302e2025-01-27T15:22:40ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762025-01-01391n/an/a10.1111/jvim.17249Predictive factors associated with short‐term mortality in cats with feline infectious peritonitis treated with remdesivir or GS‐441524 or bothSho Goto0Tsuyoshi Kamiyoshi1Ryota Iwasaki2Morita Animal Hospital Tokyo JapanKobe Animal Clinic Kobe‐shi Hyogo JapanDepartment of Veterinary Medicine Obihiro University of Agriculture and Veterinary Medicine Obihiro Hokkaido JapanAbstract Background Although most cats with feline infectious peritonitis (FIP) respond to treatment with remdesivir or GS‐441524 or both with uneventful clinical courses, some die despite treatment. Objective Identify predictive factors associated with short‐term mortality in cats with FIP treated with IV remdesivir or PO GS‐441524 or both. Animals A total of 108 client‐owned cats with FIP. Methods Retrospective multicenter study using data collected from medical records. Factors associated with short‐term mortality, defined as death within 84 days, were identified. Univariate analysis a t‐test, Mann‐Whitney U test, or Fisher's exact test and multivariate logistic regression were performed to assess patient characteristics and clinicopathological variables between survivors and nonsurvivors. Results The short‐term mortality rate was 12.0% (95% confidence interval [CI], 6.6%‐19.7%). Univariate analysis identified plasma lactate dehydrogenase activity (LDH; P < .001) and bilirubin concentration (P = .001) as being significantly increased in nonsurvivors, whereas concentrations of albumin (P = .003), total protein (P = .03), sodium (P = .005), and potassium (P = .005) were significantly lower. Additionally, nonsurvivors were significantly less likely to be febrile (≥39.4°C; P = .006). Of these variables, only plasma LDH activity ≥323 U/L, a cut‐point determined by receiver operating characteristic curve analysis, was significantly associated with short‐term mortality by multivariate analysis (odds ratio, 15.30; 95% CI, 1.18‐198.00; P = .04). Conclusion Increased plasma LDH activity might be useful for predicting short‐term mortality, guiding monitoring, and establishing prognosis in cats with FIP.https://doi.org/10.1111/jvim.17249antiviralcoronavirusFIPprognosis
spellingShingle Sho Goto
Tsuyoshi Kamiyoshi
Ryota Iwasaki
Predictive factors associated with short‐term mortality in cats with feline infectious peritonitis treated with remdesivir or GS‐441524 or both
Journal of Veterinary Internal Medicine
antiviral
coronavirus
FIP
prognosis
title Predictive factors associated with short‐term mortality in cats with feline infectious peritonitis treated with remdesivir or GS‐441524 or both
title_full Predictive factors associated with short‐term mortality in cats with feline infectious peritonitis treated with remdesivir or GS‐441524 or both
title_fullStr Predictive factors associated with short‐term mortality in cats with feline infectious peritonitis treated with remdesivir or GS‐441524 or both
title_full_unstemmed Predictive factors associated with short‐term mortality in cats with feline infectious peritonitis treated with remdesivir or GS‐441524 or both
title_short Predictive factors associated with short‐term mortality in cats with feline infectious peritonitis treated with remdesivir or GS‐441524 or both
title_sort predictive factors associated with short term mortality in cats with feline infectious peritonitis treated with remdesivir or gs 441524 or both
topic antiviral
coronavirus
FIP
prognosis
url https://doi.org/10.1111/jvim.17249
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