Impact of Aging in Microglia-Mediated D-Serine Balance in the CNS
A mild chronic inflammatory state, like that observed in aged individuals, affects microglial function, inducing a dysfunctional phenotype that potentiates neuroinflammation and cytotoxicity instead of neuroprotection in response to additional challenges. Given that inflammatory activation of microg...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2018/7219732 |
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| _version_ | 1832568291789373440 |
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| author | Sebastián Beltrán-Castillo Jaime Eugenín Rommy von Bernhardi |
| author_facet | Sebastián Beltrán-Castillo Jaime Eugenín Rommy von Bernhardi |
| author_sort | Sebastián Beltrán-Castillo |
| collection | DOAJ |
| description | A mild chronic inflammatory state, like that observed in aged individuals, affects microglial function, inducing a dysfunctional phenotype that potentiates neuroinflammation and cytotoxicity instead of neuroprotection in response to additional challenges. Given that inflammatory activation of microglia promotes increased release of D-serine, we postulate that age-dependent inflammatory brain environment leads to microglia-mediated changes on the D-serine-regulated glutamatergic transmission. Furthermore, D-serine dysregulation, in addition to affecting synaptogenesis and synaptic plasticity, appears also to potentiate NMDAR-dependent excitotoxicity, promoting neurodegeneration and cognitive impairment. D-serine dysregulation promoted by microglia could have a role in age-related cognitive impairment and in the induction and progression of neurodegenerative processes like Alzheimer’s disease. |
| format | Article |
| id | doaj-art-63cf0b2717aa4fc8be32f8e091936488 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-63cf0b2717aa4fc8be32f8e0919364882025-02-03T00:59:25ZengWileyMediators of Inflammation0962-93511466-18612018-01-01201810.1155/2018/72197327219732Impact of Aging in Microglia-Mediated D-Serine Balance in the CNSSebastián Beltrán-Castillo0Jaime Eugenín1Rommy von Bernhardi2Departamento de Neurología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, ChileDepartamento de Biología, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago, ChileDepartamento de Neurología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, ChileA mild chronic inflammatory state, like that observed in aged individuals, affects microglial function, inducing a dysfunctional phenotype that potentiates neuroinflammation and cytotoxicity instead of neuroprotection in response to additional challenges. Given that inflammatory activation of microglia promotes increased release of D-serine, we postulate that age-dependent inflammatory brain environment leads to microglia-mediated changes on the D-serine-regulated glutamatergic transmission. Furthermore, D-serine dysregulation, in addition to affecting synaptogenesis and synaptic plasticity, appears also to potentiate NMDAR-dependent excitotoxicity, promoting neurodegeneration and cognitive impairment. D-serine dysregulation promoted by microglia could have a role in age-related cognitive impairment and in the induction and progression of neurodegenerative processes like Alzheimer’s disease.http://dx.doi.org/10.1155/2018/7219732 |
| spellingShingle | Sebastián Beltrán-Castillo Jaime Eugenín Rommy von Bernhardi Impact of Aging in Microglia-Mediated D-Serine Balance in the CNS Mediators of Inflammation |
| title | Impact of Aging in Microglia-Mediated D-Serine Balance in the CNS |
| title_full | Impact of Aging in Microglia-Mediated D-Serine Balance in the CNS |
| title_fullStr | Impact of Aging in Microglia-Mediated D-Serine Balance in the CNS |
| title_full_unstemmed | Impact of Aging in Microglia-Mediated D-Serine Balance in the CNS |
| title_short | Impact of Aging in Microglia-Mediated D-Serine Balance in the CNS |
| title_sort | impact of aging in microglia mediated d serine balance in the cns |
| url | http://dx.doi.org/10.1155/2018/7219732 |
| work_keys_str_mv | AT sebastianbeltrancastillo impactofaginginmicrogliamediateddserinebalanceinthecns AT jaimeeugenin impactofaginginmicrogliamediateddserinebalanceinthecns AT rommyvonbernhardi impactofaginginmicrogliamediateddserinebalanceinthecns |