Vitamin D status and risk for breast cancer in Kenya
Abstract Background Vitamin D plays a critical role in bone metabolism, calcium regulation, and various cellular processes, including those linked to cancer. The biologically active form, 1,25-dihydroxyvitamin D [1,25(OH)2D], works through the Vitamin D Receptor (VDR). Polymorphisms in VDR and relat...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-07-01
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| Series: | Journal of Health, Population and Nutrition |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s41043-025-00874-7 |
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| Summary: | Abstract Background Vitamin D plays a critical role in bone metabolism, calcium regulation, and various cellular processes, including those linked to cancer. The biologically active form, 1,25-dihydroxyvitamin D [1,25(OH)2D], works through the Vitamin D Receptor (VDR). Polymorphisms in VDR and related genes have been associated with cancer risk, including breast cancer. This case-control study aimed to investigate the relationship between serum vitamin D levels and breast cancer among Kenyan women. Methods Serum 25-hydroxyvitamin D [25(OH)D] levels were measured in 112 breast cancer patients and 106 controls using electrochemiluminescence. Results Results indicated that 81.2% of participants had deficient or insufficient vitamin D levels, with controls showing slightly higher sufficient levels compared to cases. Although previous studies suggested an association between higher vitamin D levels and reduced breast cancer risk, our findings revealed no significant link between vitamin D levels and various demographic factors, including BMI. Conclusion The study underscores the need for public awareness about vitamin D supplementation and further research to clarify the role of vitamin D in breast cancer development, particularly in populations with widespread vitamin D deficiency. |
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| ISSN: | 2072-1315 |