Multiple Sclerosis and Obesity: Possible Roles of Adipokines
Multiple Sclerosis (MS) is an autoimmune disorder of the Central Nervous System that has been associated with several environmental factors, such as diet and obesity. The possible link between MS and obesity has become more interesting in recent years since the discovery of the remarkable properties...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2016/4036232 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832559076221911040 |
|---|---|
| author | José de Jesús Guerrero-García Lucrecia Carrera-Quintanar Rocío Ivette López-Roa Ana Laura Márquez-Aguirre Argelia Esperanza Rojas-Mayorquín Daniel Ortuño-Sahagún |
| author_facet | José de Jesús Guerrero-García Lucrecia Carrera-Quintanar Rocío Ivette López-Roa Ana Laura Márquez-Aguirre Argelia Esperanza Rojas-Mayorquín Daniel Ortuño-Sahagún |
| author_sort | José de Jesús Guerrero-García |
| collection | DOAJ |
| description | Multiple Sclerosis (MS) is an autoimmune disorder of the Central Nervous System that has been associated with several environmental factors, such as diet and obesity. The possible link between MS and obesity has become more interesting in recent years since the discovery of the remarkable properties of adipose tissue. Once MS is initiated, obesity can contribute to increased disease severity by negatively influencing disease progress and treatment response, but, also, obesity in early life is highly relevant as a susceptibility factor and causally related risk for late MS development. The aim of this review was to discuss recent evidence about the link between obesity, as a chronic inflammatory state, and the pathogenesis of MS as a chronic autoimmune and inflammatory disease. First, we describe the main cells involved in MS pathogenesis, both from neural tissue and from the immune system, and including a new participant, the adipocyte, focusing on their roles in MS. Second, we concentrate on the role of several adipokines that are able to participate in the mediation of the immune response in MS and on the possible cross talk between the latter. Finally, we explore recent therapy that involves the transplantation of adipocyte precursor cells for the treatment of MS. |
| format | Article |
| id | doaj-art-63b22f0436fb4d6aa262e88958f6f60e |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-63b22f0436fb4d6aa262e88958f6f60e2025-02-03T01:30:51ZengWileyMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/40362324036232Multiple Sclerosis and Obesity: Possible Roles of AdipokinesJosé de Jesús Guerrero-García0Lucrecia Carrera-Quintanar1Rocío Ivette López-Roa2Ana Laura Márquez-Aguirre3Argelia Esperanza Rojas-Mayorquín4Daniel Ortuño-Sahagún5U.M.A.E. Hospital de Pediatría, C.M.N.O., Instituto Mexicano del Seguro Social, Guadalajara, JAL, MexicoInstituto de Investigación en Ciencias Biomédicas (IICB), CUCS, Universidad de Guadalajara, Guadalajara, JAL, MexicoDepartamento de Farmacobiología, CUCEI, Universidad de Guadalajara, Guadalajara, JAL, MexicoUnidad de Biotecnología Médica y Farmacéutica, Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco A. C., Guadalajara, JAL, MexicoDepartamento de Ciencias Ambientales, Instituto de Neurociencias, CUCBA, Universidad de Guadalajara, Guadalajara, JAL, MexicoInstituto de Investigación en Ciencias Biomédicas (IICB), CUCS, Universidad de Guadalajara, Guadalajara, JAL, MexicoMultiple Sclerosis (MS) is an autoimmune disorder of the Central Nervous System that has been associated with several environmental factors, such as diet and obesity. The possible link between MS and obesity has become more interesting in recent years since the discovery of the remarkable properties of adipose tissue. Once MS is initiated, obesity can contribute to increased disease severity by negatively influencing disease progress and treatment response, but, also, obesity in early life is highly relevant as a susceptibility factor and causally related risk for late MS development. The aim of this review was to discuss recent evidence about the link between obesity, as a chronic inflammatory state, and the pathogenesis of MS as a chronic autoimmune and inflammatory disease. First, we describe the main cells involved in MS pathogenesis, both from neural tissue and from the immune system, and including a new participant, the adipocyte, focusing on their roles in MS. Second, we concentrate on the role of several adipokines that are able to participate in the mediation of the immune response in MS and on the possible cross talk between the latter. Finally, we explore recent therapy that involves the transplantation of adipocyte precursor cells for the treatment of MS.http://dx.doi.org/10.1155/2016/4036232 |
| spellingShingle | José de Jesús Guerrero-García Lucrecia Carrera-Quintanar Rocío Ivette López-Roa Ana Laura Márquez-Aguirre Argelia Esperanza Rojas-Mayorquín Daniel Ortuño-Sahagún Multiple Sclerosis and Obesity: Possible Roles of Adipokines Mediators of Inflammation |
| title | Multiple Sclerosis and Obesity: Possible Roles of Adipokines |
| title_full | Multiple Sclerosis and Obesity: Possible Roles of Adipokines |
| title_fullStr | Multiple Sclerosis and Obesity: Possible Roles of Adipokines |
| title_full_unstemmed | Multiple Sclerosis and Obesity: Possible Roles of Adipokines |
| title_short | Multiple Sclerosis and Obesity: Possible Roles of Adipokines |
| title_sort | multiple sclerosis and obesity possible roles of adipokines |
| url | http://dx.doi.org/10.1155/2016/4036232 |
| work_keys_str_mv | AT josedejesusguerrerogarcia multiplesclerosisandobesitypossiblerolesofadipokines AT lucreciacarreraquintanar multiplesclerosisandobesitypossiblerolesofadipokines AT rocioivettelopezroa multiplesclerosisandobesitypossiblerolesofadipokines AT analauramarquezaguirre multiplesclerosisandobesitypossiblerolesofadipokines AT argeliaesperanzarojasmayorquin multiplesclerosisandobesitypossiblerolesofadipokines AT danielortunosahagun multiplesclerosisandobesitypossiblerolesofadipokines |