TGF-β induces cholesterol accumulation to regulate the secretion of tumor-derived extracellular vesicles

TGF-β induces cholesterol accumulation to regulate the secretion of tumor-derived extracellular vesicles

Abstract Background Cancer cells are avid extracellular vesicle (EV) producers. EVs transport transforming growth factor-β (TGF-β), which is commonly activated under late stages of cancer progression. Nevertheless, whether TGF-β signaling coordinates EV biogenesis is a relevant topic that remains mi...

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Bibliographic Details
Main Authors: Dorival Mendes Rodrigues-Junior, Chrysoula Tsirigoti, Konstantina Psatha, Dimitris Kletsas, Michalis Aivaliotis, Carl-Henrik Heldin, Aristidis Moustakas
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Cancer
Cholesterol
Extracellular
Vesicles
Matrix metalloproteinase
Transforming growth factor β
Online Access:https://doi.org/10.1186/s13046-025-03291-0
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