Cutaneous adverse drug reaction associated with topical use of benzyl benzoate in a dog
ABSTRACT: Cutaneous adverse drug reactions (CADR) are unexpected dermatological reactions caused by medications. CADRs may mimic any type of dermatosis, including contact dermatitis (CD). This paper described a case of a CADR resulting from the topical use of benzyl benzoate in a dog. A two year old...
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Universidade Federal de Santa Maria
2025-01-01
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| Series: | Ciência Rural |
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| _version_ | 1832592455125434368 |
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| author | Fabiana Wurster Strey Marinara Macelai Leite Jéssica Vargas Bruno Leite Anjos |
| author_facet | Fabiana Wurster Strey Marinara Macelai Leite Jéssica Vargas Bruno Leite Anjos |
| author_sort | Fabiana Wurster Strey |
| collection | DOAJ |
| description | ABSTRACT: Cutaneous adverse drug reactions (CADR) are unexpected dermatological reactions caused by medications. CADRs may mimic any type of dermatosis, including contact dermatitis (CD). This paper described a case of a CADR resulting from the topical use of benzyl benzoate in a dog. A two year old unneutered male Pit Bull was referred for a medical consultation due to skin lesions in the cervical region. The owner reported bathing this dog routinely using 10% benzyl benzoate (BB)-based scabicidal soap, without rinsing it off at the end. An ulcerative, draining maculopapular skin lesion was observed in the dorsal region of the neck extending to the interscapular region. A surgical skin biopsy was then performed and microscopically an area of ulcerated epidermis was observed with apoptosis of transepidermal keratinocytes associated with a mixed infiltrate. Interface dermatitis with a predominance of lymphocytes in the hair follicle region, multifocal areas of mild spongiosis, mild vacuolar degeneration of keratinocytes and sub-corneal pustule was also identified. Bathing with the BB-based scabicidal soap was discontinued and a new shampoo was introduced. Topical dexamethasone, neomycin sulfate, bacitracin zinc, griseofulvin, and benzocaine treatment was started. Within 48 hours of treatment, skin revitalization was already significant and total healing took place approximately three weeks after the first appointment. Considering the findings observed in this case, it can be concluded that prolonged topical exposure to BB, due to misuse of the product, may cause a CADR characterized by irritant CD in dogs. |
| format | Article |
| id | doaj-art-6392e148d14c4f87a23c1c3aca0e7908 |
| institution | Kabale University |
| issn | 1678-4596 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Universidade Federal de Santa Maria |
| record_format | Article |
| series | Ciência Rural |
| spelling | doaj-art-6392e148d14c4f87a23c1c3aca0e79082025-01-21T07:44:43ZengUniversidade Federal de Santa MariaCiência Rural1678-45962025-01-0155410.1590/0103-8478cr20240220Cutaneous adverse drug reaction associated with topical use of benzyl benzoate in a dogFabiana Wurster Streyhttps://orcid.org/0000-0002-9072-7080Marinara Macelai Leitehttps://orcid.org/0000-0002-9820-5623Jéssica Vargashttps://orcid.org/0009-0009-1805-7121Bruno Leite Anjoshttps://orcid.org/0000-0001-7606-6055ABSTRACT: Cutaneous adverse drug reactions (CADR) are unexpected dermatological reactions caused by medications. CADRs may mimic any type of dermatosis, including contact dermatitis (CD). This paper described a case of a CADR resulting from the topical use of benzyl benzoate in a dog. A two year old unneutered male Pit Bull was referred for a medical consultation due to skin lesions in the cervical region. The owner reported bathing this dog routinely using 10% benzyl benzoate (BB)-based scabicidal soap, without rinsing it off at the end. An ulcerative, draining maculopapular skin lesion was observed in the dorsal region of the neck extending to the interscapular region. A surgical skin biopsy was then performed and microscopically an area of ulcerated epidermis was observed with apoptosis of transepidermal keratinocytes associated with a mixed infiltrate. Interface dermatitis with a predominance of lymphocytes in the hair follicle region, multifocal areas of mild spongiosis, mild vacuolar degeneration of keratinocytes and sub-corneal pustule was also identified. Bathing with the BB-based scabicidal soap was discontinued and a new shampoo was introduced. Topical dexamethasone, neomycin sulfate, bacitracin zinc, griseofulvin, and benzocaine treatment was started. Within 48 hours of treatment, skin revitalization was already significant and total healing took place approximately three weeks after the first appointment. Considering the findings observed in this case, it can be concluded that prolonged topical exposure to BB, due to misuse of the product, may cause a CADR characterized by irritant CD in dogs.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782025000400602&lng=en&tlng=encaninedermatopathymicroscopysarnicidal soapskin biopsy |
| spellingShingle | Fabiana Wurster Strey Marinara Macelai Leite Jéssica Vargas Bruno Leite Anjos Cutaneous adverse drug reaction associated with topical use of benzyl benzoate in a dog Ciência Rural canine dermatopathy microscopy sarnicidal soap skin biopsy |
| title | Cutaneous adverse drug reaction associated with topical use of benzyl benzoate in a dog |
| title_full | Cutaneous adverse drug reaction associated with topical use of benzyl benzoate in a dog |
| title_fullStr | Cutaneous adverse drug reaction associated with topical use of benzyl benzoate in a dog |
| title_full_unstemmed | Cutaneous adverse drug reaction associated with topical use of benzyl benzoate in a dog |
| title_short | Cutaneous adverse drug reaction associated with topical use of benzyl benzoate in a dog |
| title_sort | cutaneous adverse drug reaction associated with topical use of benzyl benzoate in a dog |
| topic | canine dermatopathy microscopy sarnicidal soap skin biopsy |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782025000400602&lng=en&tlng=en |
| work_keys_str_mv | AT fabianawursterstrey cutaneousadversedrugreactionassociatedwithtopicaluseofbenzylbenzoateinadog AT marinaramacelaileite cutaneousadversedrugreactionassociatedwithtopicaluseofbenzylbenzoateinadog AT jessicavargas cutaneousadversedrugreactionassociatedwithtopicaluseofbenzylbenzoateinadog AT brunoleiteanjos cutaneousadversedrugreactionassociatedwithtopicaluseofbenzylbenzoateinadog |