Assessment of local sensitivity in incomplete retinal pigment epithelium and outer retinal atrophy (iRORA) lesions in intermediate age-related macular degeneration (iAMD)
Objective Lesions of incomplete retinal pigment epithelium and outer retinal atrophy (iRORA) are associated with disease progression in intermediate age-related macular degeneration (AMD). However, the corresponding functional impact of these precursor lesions is unknown and needs to be established....
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2024-03-01
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| Series: | BMJ Open Ophthalmology |
| Online Access: | https://bmjophth.bmj.com/content/9/1/e001638.full |
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| author | Frank G Holz Marlene Saßmannshausen Thomas Ach Leon von der Emde Julius Ameln Alessandra Carmichael-Martins Wolf M Harmening |
| author_facet | Frank G Holz Marlene Saßmannshausen Thomas Ach Leon von der Emde Julius Ameln Alessandra Carmichael-Martins Wolf M Harmening |
| author_sort | Frank G Holz |
| collection | DOAJ |
| description | Objective Lesions of incomplete retinal pigment epithelium and outer retinal atrophy (iRORA) are associated with disease progression in intermediate age-related macular degeneration (AMD). However, the corresponding functional impact of these precursor lesions is unknown and needs to be established.Methods and analysis We present a cross-sectional study of four patients with intermediate AMD employing clinical-grade MAIA (stimulus size: 0.43°, ~125 µm) and adaptive optics scanning light ophthalmoscope (AOSLO, stimulus size 0.07°, ~20 µm) based microperimetry (MP) to assess the specific impact of iRORA lesions on retinal sensitivity.Results AOSLO imaging showed overall reduced photoreceptor reflectivity and patches of hyporeflective regions at drusen with interspersed hyperreflective foci in iRORA regions. MAIA-MP yielded an average retinal sensitivity loss of -7.3 ±3.1 dB at iRORA lesions compared to the in-eye control. With AOSLO-MP, the corresponding sensitivity loss was -20.1 ±4.8 dB.Conclusion We demonstrated that iRORA lesions are associated with a severe impairment in retinal sensitivity. Larger cohort studies will be necessary to validate our findings. |
| format | Article |
| id | doaj-art-63856711823543da8d98323bcf0bab14 |
| institution | Kabale University |
| issn | 2397-3269 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open Ophthalmology |
| spelling | doaj-art-63856711823543da8d98323bcf0bab142025-02-06T10:20:10ZengBMJ Publishing GroupBMJ Open Ophthalmology2397-32692024-03-019110.1136/bmjophth-2024-001638Assessment of local sensitivity in incomplete retinal pigment epithelium and outer retinal atrophy (iRORA) lesions in intermediate age-related macular degeneration (iAMD)Frank G Holz0Marlene Saßmannshausen1Thomas Ach2Leon von der Emde3Julius Ameln4Alessandra Carmichael-Martins5Wolf M Harmening6University Eye Hospital Bonn, Bonn, GermanyDepartment of Ophthalmology, University Hospital Bonn, Bonn, GermanyDepartment of Ophthalmology, University Hospital Bonn, Bonn, GermanyDepartment of Ophthalmology, University Hospital Bonn, Bonn, GermanyDepartment of Ophthalmology, University Hospital Bonn, Bonn, GermanyDepartment of Ophthalmology, University Hospital Bonn, Bonn, GermanyDepartment of Ophthalmology, University Hospital Bonn, Bonn, GermanyObjective Lesions of incomplete retinal pigment epithelium and outer retinal atrophy (iRORA) are associated with disease progression in intermediate age-related macular degeneration (AMD). However, the corresponding functional impact of these precursor lesions is unknown and needs to be established.Methods and analysis We present a cross-sectional study of four patients with intermediate AMD employing clinical-grade MAIA (stimulus size: 0.43°, ~125 µm) and adaptive optics scanning light ophthalmoscope (AOSLO, stimulus size 0.07°, ~20 µm) based microperimetry (MP) to assess the specific impact of iRORA lesions on retinal sensitivity.Results AOSLO imaging showed overall reduced photoreceptor reflectivity and patches of hyporeflective regions at drusen with interspersed hyperreflective foci in iRORA regions. MAIA-MP yielded an average retinal sensitivity loss of -7.3 ±3.1 dB at iRORA lesions compared to the in-eye control. With AOSLO-MP, the corresponding sensitivity loss was -20.1 ±4.8 dB.Conclusion We demonstrated that iRORA lesions are associated with a severe impairment in retinal sensitivity. Larger cohort studies will be necessary to validate our findings.https://bmjophth.bmj.com/content/9/1/e001638.full |
| spellingShingle | Frank G Holz Marlene Saßmannshausen Thomas Ach Leon von der Emde Julius Ameln Alessandra Carmichael-Martins Wolf M Harmening Assessment of local sensitivity in incomplete retinal pigment epithelium and outer retinal atrophy (iRORA) lesions in intermediate age-related macular degeneration (iAMD) BMJ Open Ophthalmology |
| title | Assessment of local sensitivity in incomplete retinal pigment epithelium and outer retinal atrophy (iRORA) lesions in intermediate age-related macular degeneration (iAMD) |
| title_full | Assessment of local sensitivity in incomplete retinal pigment epithelium and outer retinal atrophy (iRORA) lesions in intermediate age-related macular degeneration (iAMD) |
| title_fullStr | Assessment of local sensitivity in incomplete retinal pigment epithelium and outer retinal atrophy (iRORA) lesions in intermediate age-related macular degeneration (iAMD) |
| title_full_unstemmed | Assessment of local sensitivity in incomplete retinal pigment epithelium and outer retinal atrophy (iRORA) lesions in intermediate age-related macular degeneration (iAMD) |
| title_short | Assessment of local sensitivity in incomplete retinal pigment epithelium and outer retinal atrophy (iRORA) lesions in intermediate age-related macular degeneration (iAMD) |
| title_sort | assessment of local sensitivity in incomplete retinal pigment epithelium and outer retinal atrophy irora lesions in intermediate age related macular degeneration iamd |
| url | https://bmjophth.bmj.com/content/9/1/e001638.full |
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