Ginsenoside Rh2 regulates cardiomyocyte autophagy-dependent apoptosis through the PI3K-Akt-mTOR signaling pathway to attenuate doxorubicin-induced cardiotoxicity

Ginsenoside Rh2 regulates cardiomyocyte autophagy-dependent apoptosis through the PI3K-Akt-mTOR signaling pathway to attenuate doxorubicin-induced cardiotoxicity

Abstract Doxorubicin (DOX)-induced cardiotoxicity has become a major concern and is considered a limitation for the use of DOX in oncology treatment. Ginsenoside Rh2 (Rh2) is a ginseng extract with anti-inflammatory, antioxidant and cell cycle regulating activities. The aim of this study was to inve...

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Bibliographic Details
Main Authors: Youping Wu, Sheng Zhang, Liqiang Gu, Cong Xu, Xiaobo Lin, Hu Wang
Format: Article
Language:English
Published: SpringerOpen 2025-04-01
Series:Applied Biological Chemistry
Subjects:
Doxorubicin
Ginsenoside Rh2
Cardioprotective effect
Autophagy
Apoptosis
PI3K-Akt-mTOR signaling
Online Access:https://doi.org/10.1186/s13765-025-00986-y
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